ID   LFG1_RAT                Reviewed;         348 AA.
AC   Q6P6R0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Protein lifeguard 1;
DE   AltName: Full=Glutamate [NMDA] receptor-associated protein 1;
DE   AltName: Full=NMDA receptor glutamate-binding subunit;
GN   Name=Grina; Synonyms=Lfg1, Nmdara1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Potential apoptotic regulator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BI1 family. LFG subfamily. {ECO:0000305}.
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DR   EMBL; BC062074; AAH62074.1; -; mRNA.
DR   RefSeq; NP_695220.4; NM_153308.4.
DR   AlphaFoldDB; Q6P6R0; -.
DR   STRING; 10116.ENSRNOP00000056356; -.
DR   BindingDB; Q6P6R0; -.
DR   ChEMBL; CHEMBL4129; -.
DR   PaxDb; Q6P6R0; -.
DR   GeneID; 266668; -.
DR   KEGG; rno:266668; -.
DR   UCSC; RGD:628873; rat.
DR   CTD; 2907; -.
DR   RGD; 628873; Grina.
DR   VEuPathDB; HostDB:ENSRNOG00000029941; -.
DR   eggNOG; KOG2322; Eukaryota.
DR   HOGENOM; CLU_058671_3_0_1; -.
DR   InParanoid; Q6P6R0; -.
DR   OMA; YYVSYAF; -.
DR   OrthoDB; 1290306at2759; -.
DR   PRO; PR:Q6P6R0; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000029941; Expressed in cerebellum and 18 other tissues.
DR   Genevisible; Q6P6R0; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; NAS:RGD.
DR   GO; GO:0044325; F:transmembrane transporter binding; ISO:RGD.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; ISO:RGD.
DR   GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; ISO:RGD.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; PTHR23291; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..348
FT                   /note="Protein lifeguard 1"
FT                   /id="PRO_0000314441"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..45
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..104
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   348 AA;  38594 MW;  A780611FC30D2861 CRC64;
     MSHEKSFLVS GDSYPPPNPG YPVGPQAPMP PYVQPPYPGA PYPQAAFQPS PYGQPGYPHG
     PGPYPQGGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPPPF QDPGSPQHGN YQEEGPPSYY
     DNQDFPSVNW DKSIRQAFIR KVFLVLTLQL SVTLSTVAIF TFVGEVKGFV RANVWTYYVS
     YAIFFISLIV LSCCGDFRRK HPWNLVALSI LTISLSYMVG MIASFYNTEA VIMAVGITTA
     VCFTVVIFSM QTRYDFTSCM GVLLVSVVVL FIFAILCIFI RNRILEIVYA SLGALLFTCF
     LAVDTQLLLG NKQLSLSPEE YVFAALNLYT DIINIFLYIL TIIGRAKE