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LFG2_ARATH
ID   LFG2_ARATH              Reviewed;         239 AA.
AC   Q9M1V9;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Protein LIFEGUARD 2 {ECO:0000303|PubMed:23888068};
DE            Short=AtLFG2 {ECO:0000303|PubMed:23888068};
DE   AltName: Full=Protein BRZ-INSENSITIVE-LONG HYPOCOTYLS 4 {ECO:0000303|PubMed:19202280};
GN   Name=LFG2 {ECO:0000303|PubMed:23888068};
GN   Synonyms=BIL4 {ECO:0000303|PubMed:19202280};
GN   OrderedLocusNames=At3g63310 {ECO:0000312|Araport:AT3G63310};
GN   ORFNames=MAA21.11 {ECO:0000312|EMBL:CAB86432.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY.
RX   PubMed=17064408; DOI=10.1186/gb-2006-7-10-r96;
RA   Moriyama E.N., Strope P.K., Opiyo S.O., Chen Z., Jones A.M.;
RT   "Mining the Arabidopsis thaliana genome for highly-divergent seven
RT   transmembrane receptors.";
RL   Genome Biol. 7:R96.1-R96.9(2006).
RN   [5]
RP   FUNCTION, REGULATION BY BRZ, TISSUE SPECIFICITY, AND GENE FAMILY.
RC   STRAIN=cv. Columbia;
RX   PubMed=19202280; DOI=10.1271/bbb.80752;
RA   Yamagami A., Nakazawa M., Matsui M., Tujimoto M., Sakuta M., Asami T.,
RA   Nakano T.;
RT   "Chemical genetics reveal the novel transmembrane protein BIL4, which
RT   mediates plant cell elongation in brassinosteroid signaling.";
RL   Biosci. Biotechnol. Biochem. 73:415-421(2009).
RN   [6]
RP   FUNCTION (MICROBIAL INFECTION), DISRUPTION PHENOTYPE, TISSUE SPECIFICITY,
RP   GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=23888068; DOI=10.1093/jxb/ert217;
RA   Weis C., Hueckelhoven R., Eichmann R.;
RT   "LIFEGUARD proteins support plant colonization by biotrophic powdery mildew
RT   fungi.";
RL   J. Exp. Bot. 64:3855-3867(2013).
CC   -!- FUNCTION: Regulates the brassinosteroid (BR) signaling pathway that
CC       mediates cell elongation and organ morphogenesis (PubMed:19202280).
CC       {ECO:0000269|PubMed:19202280}.
CC   -!- FUNCTION: (Microbial infection) Facilitates the development of the
CC       powdery mildew fungus E.cruciferarum. {ECO:0000269|PubMed:23888068}.
CC   -!- FUNCTION: (Microbial infection) May prevent cell death upon A.alternata
CC       f.sp. lycopersici (AAL) toxin treatment. {ECO:0000269|PubMed:23888068}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in seedlings, roots, leaves,
CC       inflorescences and flowers. {ECO:0000269|PubMed:19202280,
CC       ECO:0000269|PubMed:23888068}.
CC   -!- INDUCTION: Repressed by Brz, a triazole compound that acts as a
CC       brassinosteroid (BR)-specific inhibitor. {ECO:0000269|PubMed:19202280}.
CC   -!- DISRUPTION PHENOTYPE: Delayed development of the powdery mildew fungus
CC       E.cruciferarum. Increased cell death upon A.alternata f.sp. lycopersici
CC       (AAL) toxin treatment. {ECO:0000269|PubMed:23888068}.
CC   -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000305}.
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DR   EMBL; AL138648; CAB86432.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE80466.1; -; Genomic_DNA.
DR   EMBL; BT020236; AAV74230.1; -; mRNA.
DR   EMBL; BT021132; AAX22267.1; -; mRNA.
DR   PIR; T48120; T48120.
DR   RefSeq; NP_191890.1; NM_116196.3.
DR   AlphaFoldDB; Q9M1V9; -.
DR   SMR; Q9M1V9; -.
DR   IntAct; Q9M1V9; 19.
DR   STRING; 3702.AT3G63310.1; -.
DR   TCDB; 1.A.14.3.13; the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family.
DR   iPTMnet; Q9M1V9; -.
DR   PaxDb; Q9M1V9; -.
DR   PRIDE; Q9M1V9; -.
DR   ProteomicsDB; 238456; -.
DR   EnsemblPlants; AT3G63310.1; AT3G63310.1; AT3G63310.
DR   GeneID; 825506; -.
DR   Gramene; AT3G63310.1; AT3G63310.1; AT3G63310.
DR   KEGG; ath:AT3G63310; -.
DR   Araport; AT3G63310; -.
DR   TAIR; locus:2077309; AT3G63310.
DR   eggNOG; KOG2322; Eukaryota.
DR   HOGENOM; CLU_058671_0_1_1; -.
DR   InParanoid; Q9M1V9; -.
DR   OMA; NRSHQAE; -.
DR   OrthoDB; 1290306at2759; -.
DR   PhylomeDB; Q9M1V9; -.
DR   PRO; PR:Q9M1V9; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9M1V9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IMP:TAIR.
DR   GO; GO:0050832; P:defense response to fungus; IMP:UniProtKB.
DR   GO; GO:0060548; P:negative regulation of cell death; IMP:UniProtKB.
DR   GO; GO:1905421; P:regulation of plant organ morphogenesis; IMP:UniProtKB.
DR   GO; GO:0009826; P:unidimensional cell growth; IMP:TAIR.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; PTHR23291; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   2: Evidence at transcript level;
KW   Brassinosteroid signaling pathway; Developmental protein; Membrane;
KW   Plant defense; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..239
FT                   /note="Protein LIFEGUARD 2"
FT                   /id="PRO_0000441630"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  26908 MW;  5E40C734D952C43B CRC64;
     MWNQKHDLES AQTPLYPMMS ESPELRWSFI RKVYSIISIQ LLVTIAVAAT VVKVHSISVF
     FTTTTAGFAL YILLILTPLI VMCPLYYYHQ KHPVNYLLLG IFTVALAFAV GLTCAFTSGK
     VILESVILTA VVVISLTLYT FWAAKRGHDF NFLGPFLFGA VIVLMVFSFI QILFPLGKIS
     VMIYGCLASI IFCGYIVYDT DNLIKRHSYD EYIWAAVSLY LDVINLFLSL LTLLRAVDS
 
 
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