LFG2_BOVIN
ID LFG2_BOVIN Reviewed; 316 AA.
AC Q1LZ71;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Protein lifeguard 2;
DE AltName: Full=Fas apoptotic inhibitory molecule 2;
GN Name=FAIM2; Synonyms=LFG2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Antiapoptotic protein which protects cells uniquely from Fas-
CC induced apoptosis. Regulates Fas-mediated apoptosis in neurons by
CC interfering with caspase-8 activation. Plays a role in cerebellar
CC development by affecting cerebellar size, internal granular layer (IGL)
CC thickness, and Purkinje cell (PC) development (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FAS/TNFRSF6 and BAX. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Membrane raft {ECO:0000250}. Postsynaptic cell
CC membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BI1 family. LFG subfamily. {ECO:0000305}.
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DR EMBL; BC116167; AAI16168.1; -; mRNA.
DR RefSeq; NP_001068886.1; NM_001075418.2.
DR AlphaFoldDB; Q1LZ71; -.
DR SMR; Q1LZ71; -.
DR STRING; 9913.ENSBTAP00000023267; -.
DR PaxDb; Q1LZ71; -.
DR Ensembl; ENSBTAT00000068256; ENSBTAP00000063728; ENSBTAG00000017504.
DR GeneID; 509790; -.
DR KEGG; bta:509790; -.
DR CTD; 23017; -.
DR VEuPathDB; HostDB:ENSBTAG00000017504; -.
DR VGNC; VGNC:28710; FAIM2.
DR eggNOG; KOG2322; Eukaryota.
DR GeneTree; ENSGT01050000244890; -.
DR HOGENOM; CLU_058671_3_2_1; -.
DR InParanoid; Q1LZ71; -.
DR OMA; YPGDTEM; -.
DR OrthoDB; 1290306at2759; -.
DR TreeFam; TF319996; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000017504; Expressed in prefrontal cortex and 100 other tissues.
DR ExpressionAtlas; Q1LZ71; baseline and differential.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0021681; P:cerebellar granular layer development; ISS:UniProtKB.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; ISS:UniProtKB.
DR GO; GO:0021680; P:cerebellar Purkinje cell layer development; ISS:UniProtKB.
DR GO; GO:0021549; P:cerebellum development; ISS:UniProtKB.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0043523; P:regulation of neuron apoptotic process; ISS:UniProtKB.
DR GO; GO:0002931; P:response to ischemia; IEA:Ensembl.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR PANTHER; PTHR23291; PTHR23291; 1.
DR Pfam; PF01027; Bax1-I; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cell membrane; Glycoprotein; Membrane;
KW Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..316
FT /note="Protein lifeguard 2"
FT /id="PRO_0000326145"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 316 AA; 35184 MW; 64C0898AF6786E03 CRC64;
MTQGKLSVAN KAPGTEGQQQ ANGEKKETPA VPSAPPSYEE ATSGEGLKAG AFPPAPSAVP
LHPSWAYVDP NSSSSYESGF PTGDHEFFTT FSWDDQKVRR VFIRKVYTIL LIQLLVTLGV
VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTIFTLSMA
YLTGMLSSYY NTTSVLLCLS ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI
LAILLPFQYV PWLHAVYAVL GAGVFTLFLA FDTQLLMGSR RHSLSPEEYI FGALNIYLDI
IYIFTFFLQL FGTNRE