LFG3_ARATH
ID LFG3_ARATH Reviewed; 248 AA.
AC Q9ZQX7; Q5XV88;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 137.
DE RecName: Full=Protein LIFEGUARD 3 {ECO:0000303|PubMed:23888068};
DE Short=AtLFG3 {ECO:0000303|PubMed:23888068};
GN Name=LFG3 {ECO:0000303|PubMed:23888068};
GN OrderedLocusNames=At4g02690 {ECO:0000312|Araport:AT4G02690};
GN ORFNames=T10P11.23 {ECO:0000312|EMBL:AAC78271.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=cv. Columbia;
RX PubMed=16244158; DOI=10.1104/pp.105.063479;
RA Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT reveals numerous transcript variants.";
RL Plant Physiol. 139:1323-1337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=17064408; DOI=10.1186/gb-2006-7-10-r96;
RA Moriyama E.N., Strope P.K., Opiyo S.O., Chen Z., Jones A.M.;
RT "Mining the Arabidopsis thaliana genome for highly-divergent seven
RT transmembrane receptors.";
RL Genome Biol. 7:R96.1-R96.9(2006).
RN [6]
RP GENE FAMILY.
RX PubMed=19202280; DOI=10.1271/bbb.80752;
RA Yamagami A., Nakazawa M., Matsui M., Tujimoto M., Sakuta M., Asami T.,
RA Nakano T.;
RT "Chemical genetics reveal the novel transmembrane protein BIL4, which
RT mediates plant cell elongation in brassinosteroid signaling.";
RL Biosci. Biotechnol. Biochem. 73:415-421(2009).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=23888068; DOI=10.1093/jxb/ert217;
RA Weis C., Hueckelhoven R., Eichmann R.;
RT "LIFEGUARD proteins support plant colonization by biotrophic powdery mildew
RT fungi.";
RL J. Exp. Bot. 64:3855-3867(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9ZQX7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ZQX7-2; Sequence=VSP_059078, VSP_059079;
CC -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000305}.
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DR EMBL; AC002330; AAC78271.1; -; Genomic_DNA.
DR EMBL; AL161495; CAB77754.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82214.1; -; Genomic_DNA.
DR EMBL; AY735633; AAU44503.1; -; mRNA.
DR EMBL; AY735634; AAU44504.1; -; mRNA.
DR EMBL; AY924811; AAX23886.1; -; mRNA.
DR PIR; T01080; T01080.
DR RefSeq; NP_192178.1; NM_116503.2. [Q9ZQX7-1]
DR AlphaFoldDB; Q9ZQX7; -.
DR SMR; Q9ZQX7; -.
DR STRING; 3702.AT4G02690.1; -.
DR PaxDb; Q9ZQX7; -.
DR EnsemblPlants; AT4G02690.1; AT4G02690.1; AT4G02690. [Q9ZQX7-1]
DR GeneID; 828203; -.
DR Gramene; AT4G02690.1; AT4G02690.1; AT4G02690. [Q9ZQX7-1]
DR KEGG; ath:AT4G02690; -.
DR Araport; AT4G02690; -.
DR TAIR; locus:2132318; AT4G02690.
DR eggNOG; KOG2322; Eukaryota.
DR HOGENOM; CLU_058671_0_1_1; -.
DR InParanoid; Q9ZQX7; -.
DR OMA; WLFFMYY; -.
DR OrthoDB; 1290306at2759; -.
DR PhylomeDB; Q9ZQX7; -.
DR PRO; PR:Q9ZQX7; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9ZQX7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0034620; P:cellular response to unfolded protein; IMP:TAIR.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR PANTHER; PTHR23291; PTHR23291; 1.
DR Pfam; PF01027; Bax1-I; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..248
FT /note="Protein LIFEGUARD 3"
FT /id="PRO_0000441631"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 129..130
FT /note="KV -> MT (in isoform 2)"
FT /id="VSP_059078"
FT VAR_SEQ 131..248
FT /note="Missing (in isoform 2)"
FT /id="VSP_059079"
SQ SEQUENCE 248 AA; 28221 MW; F05F00841C87E9DD CRC64;
MYQWNLPYRK DDVETGVSSR RPLLYPAMHE NPELRWGFIR KVYSIIAFQL LATVAVAATV
VTVRPIALFF ATTGLGLALY IVIIITPLIV LCPLYYYHQK HPVNYLLLGI FTLALAFVVG
LTCAFTNGKV ILESVILTSV VVLSLTLYTF WAARKGYDFN FLGPFLFGAL TVLIFFALIQ
ILFPLGRVSV MIYGCLVSII FCGYIVYDTD NLIKRHTYDE YIWAAVSLYL DIINLFLYLL
TVLRALQR
