ID   LFHA_ECO44              Reviewed;         697 AA.
AC   D3GS80; Q5DY37;
DT   01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Putative flagellar export/assembly protein LfhA {ECO:0000305};
GN   Name=lfhA {ECO:0000303|PubMed:15687208};
GN   OrderedLocusNames=EC042_0245 {ECO:0000312|EMBL:CBG33078.1};
GN   ORFNames=Ec042-0245 {ECO:0000312|EMBL:CAH19113.1};
OS   Escherichia coli O44:H18 (strain 042 / EAEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=216592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=042 / EAEC;
RX   PubMed=15687208; DOI=10.1128/jb.187.4.1430-1440.2005;
RA   Ren C.-P., Beatson S.A., Parkhill J., Pallen M.J.;
RT   "The Flag-2 locus, an ancestral gene cluster, is potentially associated
RT   with a novel flagellar system from Escherichia coli.";
RL   J. Bacteriol. 187:1430-1440(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=042 / EAEC;
RX   PubMed=20098708; DOI=10.1371/journal.pone.0008801;
RA   Chaudhuri R.R., Sebaihia M., Hobman J.L., Webber M.A., Leyton D.L.,
RA   Goldberg M.D., Cunningham A.F., Scott-Tucker A., Ferguson P.R.,
RA   Thomas C.M., Frankel G., Tang C.M., Dudley E.G., Roberts I.S., Rasko D.A.,
RA   Pallen M.J., Parkhill J., Nataro J.P., Thomson N.R., Henderson I.R.;
RT   "Complete genome sequence and comparative metabolic profiling of the
RT   prototypical enteroaggregative Escherichia coli strain 042.";
RL   PLoS ONE 5:E8801-E8801(2010).
CC   -!- FUNCTION: Part of the flagellar gene cluster Flag-2. However, the Flag-
CC       2 flagellar system could be inactive in strain 042 due to a frameshift
CC       in lfgC. {ECO:0000305|PubMed:15687208}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
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DR   EMBL; CR753847; CAH19113.1; -; Genomic_DNA.
DR   EMBL; FN554766; CBG33078.1; -; Genomic_DNA.
DR   RefSeq; WP_001140817.1; NC_017626.1.
DR   AlphaFoldDB; D3GS80; -.
DR   SMR; D3GS80; -.
DR   KEGG; elo:EC042_0245; -.
DR   PATRIC; fig|216592.3.peg.259; -.
DR   HOGENOM; CLU_015346_3_0_6; -.
DR   OMA; WDLAFHQ; -.
DR   Proteomes; UP000001407; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.10.8.540; -; 1.
DR   Gene3D; 3.40.30.60; -; 1.
DR   Gene3D; 3.40.50.12790; -; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR025505; FHIPEP_CS.
DR   InterPro; IPR006301; FlhA.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   PANTHER; PTHR30161; PTHR30161; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   TIGRFAMs; TIGR01398; FlhA; 1.
DR   PROSITE; PS00994; FHIPEP; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..697
FT                   /note="Putative flagellar export/assembly protein LfhA"
FT                   /id="PRO_0000432475"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   697 AA;  75630 MW;  3AB4DDDD3253CF93 CRC64;
     MAKTTKSFLA LLRGGNLGVP LVILCILAMV ILPLPPALLD ILFTFNIVLA VMVLLVAVSA
     KRPLEFSLFP TILLITTLMR LTLNVASTRV VLLHGHLGAG AAGKVIESFG QVVIGGNFVV
     GFVVFIILMI INFIVVTKGA ERISEVSARF TLDAMPGKQM AIDADLNAGL INQAQAQTRR
     KDVASEADFY GAMDGASKFV RGDAIAGMMI LAINLIGGVC IGIFKYNLSA DAAFQQYVLM
     TIGDGLVAQI PSLLLSTAAA IIVTRVSDNG DIAHDVRHQL LASPSVLYTA TGIMFVLAVV
     PGMPHLPFLL FSALLGFTGW RMSKRPQAAE AEEKSLETLT RTITETSEQQ VSWETIPLIE
     PISLSLGYKL VALVDKAQGN PLTQRIRGVR QVISDGNGVL LPEIRIRENF RLKPSQYAIF
     INGIKADEAD IPADKLMALP SSETYGEIDG VLGNDPAYGM PVTWIQPAQK AKALNMGYQV
     IDSASVIATH VNKIVRSYIP DLFNYDDITQ LHNRLSSMAP RLAEDLSAAL NYSQLLKVYR
     ALLTEGVSLR DIVTIATVLV ASSTLTKDHI LLAADVRLAL RRSITHPFVR KQELTVYTLN
     NELENLLTNV VNQAQQAGKV MLDSVPVDPN MLNQFQSTMP QVKEQMKAAG KAPVLLVPPQ
     LRPLLARYAR LFAPGLHVLS YNEVPDELEL KIMGALS