LFR_ARATH
ID LFR_ARATH Reviewed; 460 AA.
AC Q9LS90; Q8LFF7;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Armadillo repeat-containing protein LFR {ECO:0000305};
DE AltName: Full=Protein LEAF AND FLOWER RELATED {ECO:0000303|PubMed:18846319};
GN Name=LFR {ECO:0000303|PubMed:18846319};
GN OrderedLocusNames=At3g22990 {ECO:0000312|Araport:AT3G22990};
GN ORFNames=MXC7.2 {ECO:0000312|EMBL:BAB02090.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=18846319; DOI=10.1007/s11103-008-9411-8;
RA Wang Z., Yuan T., Yuan C., Niu Y., Sun D., Cui S.;
RT "LFR, which encodes a novel nuclear-localized Armadillo-repeat protein,
RT affects multiple developmental processes in the aerial organs in
RT Arabidopsis.";
RL Plant Mol. Biol. 69:121-131(2009).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22461668; DOI=10.1093/mp/sss024;
RA Wang X.T., Yuan C., Yuan T.T., Cui S.J.;
RT "The Arabidopsis LFR gene is required for the formation of anther cell
RT layers and normal expression of key regulatory genes.";
RL Mol. Plant 5:993-1000(2012).
RN [7]
RP FUNCTION, INTERACTION WITH AS2, AND SUBCELLULAR LOCATION.
RX PubMed=29775508; DOI=10.1111/tpj.13973;
RA Lin X., Gu D., Zhao H., Peng Y., Zhang G., Yuan T., Li M., Wang Z.,
RA Wang X., Cui S.;
RT "LFR is functionally associated with AS2 to mediate leaf development in
RT Arabidopsis.";
RL Plant J. 0:0-0(2018).
CC -!- FUNCTION: Involved in leaf and flower development (PubMed:18846319).
CC Plays roles in leaf development partly by associating with AS2 and
CC repressing KNAT1/BP transcription (PubMed:29775508). Required for the
CC formation of anther cell layers and normal expression of genes that
CC regulates anther development (PubMed:22461668).
CC {ECO:0000269|PubMed:18846319, ECO:0000269|PubMed:22461668,
CC ECO:0000269|PubMed:29775508}.
CC -!- SUBUNIT: Interacts with AS2. {ECO:0000269|PubMed:29775508}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18846319,
CC ECO:0000269|PubMed:29775508}. Note=Tends to cluster in the nucleus as
CC discrete rounded speckles. {ECO:0000269|PubMed:18846319}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC {ECO:0000269|PubMed:18846319}.
CC -!- DISRUPTION PHENOTYPE: Developmental and morphological defects at the
CC vegetative stage in cotyledons and true leaves, and during the
CC reproductive phase in flowers and siliques. Increased abortive
CC frequency of embryos. {ECO:0000269|PubMed:18846319}.
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DR EMBL; AB026655; BAB02090.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76703.1; -; Genomic_DNA.
DR EMBL; AY072191; AAL60013.1; -; mRNA.
DR EMBL; AY096422; AAM20062.1; -; mRNA.
DR EMBL; AY084876; AAM61439.1; -; mRNA.
DR RefSeq; NP_566721.1; NM_113199.5.
DR AlphaFoldDB; Q9LS90; -.
DR SMR; Q9LS90; -.
DR BioGRID; 7205; 105.
DR STRING; 3702.AT3G22990.1; -.
DR PaxDb; Q9LS90; -.
DR PRIDE; Q9LS90; -.
DR ProteomicsDB; 238446; -.
DR EnsemblPlants; AT3G22990.1; AT3G22990.1; AT3G22990.
DR GeneID; 821873; -.
DR Gramene; AT3G22990.1; AT3G22990.1; AT3G22990.
DR KEGG; ath:AT3G22990; -.
DR Araport; AT3G22990; -.
DR TAIR; locus:2094618; AT3G22990.
DR eggNOG; ENOG502QU15; Eukaryota.
DR HOGENOM; CLU_035867_0_0_1; -.
DR InParanoid; Q9LS90; -.
DR OMA; FQCIEDY; -.
DR OrthoDB; 776394at2759; -.
DR PhylomeDB; Q9LS90; -.
DR PRO; PR:Q9LS90; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LS90; baseline and differential.
DR Genevisible; Q9LS90; AT.
DR GO; GO:0035060; C:brahma complex; IEA:InterPro.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR GO; GO:0048653; P:anther development; IMP:UniProtKB.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0009908; P:flower development; IMP:TAIR.
DR GO; GO:0048366; P:leaf development; IMP:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR021906; BAF250/Osa.
DR InterPro; IPR033388; BAF250_C.
DR PANTHER; PTHR12656; PTHR12656; 1.
DR Pfam; PF12031; BAF250_C; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Growth regulation; Nucleus; Reference proteome;
KW Repeat.
FT CHAIN 1..460
FT /note="Armadillo repeat-containing protein LFR"
FT /id="PRO_0000431234"
FT REPEAT 227..269
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 323..362
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 366..407
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 300
FT /note="N -> D (in Ref. 4; AAM61439)"
FT CONFLICT 339
FT /note="I -> V (in Ref. 4; AAM61439)"
SQ SEQUENCE 460 AA; 50112 MW; 81C85F88B2A4055A CRC64;
MQKRELGKSG GNSGGSSGPP AKRGRPFGST SANSAAAAAA AAAADAMSPS ALLGPSLLVH
NSFVEQNNRR IVLALQSGLK SEVTWALNTL TLLSFKEKED IRRDVMPLAK IAGLLDALLL
IIDDWRDIAL PKDLTRGTRV RTLGTNASVT GFGNEYDALA SIQPPGSGIG SSAAEALGKK
STGKHQSSQW WMEEDGLFNL DDEGRSEKQM CAIAASNVIR NFSFMPDNEV VMAQHRHCLE
TVFQCIHDHM TEDEELVTNS LETIVNLAHL MDLRIFSSLK QSYININEKK AVQAVVGILN
SSVKAWNCAA AELLGRLIIN PDNEPFISPL IPQIHKRLID LLSIQAVDAQ AAAVGALYNL
VEVNMDCRLK LASERWAVDR LLKVIKTPHP VPEVCRKAAM ILENLVSEPQ NRGLLLAYEN
AFAELLFQEG KYSDSFARIL YELTARSNSR VASARGIWGM
