ID   LFXI_HAEDE              Reviewed;          90 AA.
AC   P86681;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Leech factor Xa inhibitor {ECO:0000303|PubMed:10595640};
DE            Short=Lefaxin {ECO:0000303|PubMed:10595640};
DE   Flags: Fragments;
OS   Haementeria depressa (Leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Haementeria.
OX   NCBI_TaxID=279730;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 1-34, AND FUNCTION.
RC   TISSUE=Salivary gland {ECO:0000269|PubMed:10595640};
RX   PubMed=10595640;
RA   Faria F., Kelen E.M., Sampaio C.A., Bon C., Duval N.,
RA   Chudzinski-Tavassi A.M.;
RT   "A new factor Xa inhibitor (lefaxin) from the Haementeria depressa leech.";
RL   Thromb. Haemost. 82:1469-1473(1999).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 35-90.
RC   TISSUE=Salivary gland;
RA   Faria F.;
RL   Submitted (MAY-2010) to UniProtKB.
CC   -!- FUNCTION: Potent anticoagulant inhibiting the amidolytic activity of
CC       factor Xa (F10) (Ki=4nM) and reducing its ability to activate
CC       prothrombin (F2) in the prothrombinase complex (EC(50)=40nM).
CC       {ECO:0000269|PubMed:10595640}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- CAUTION: The order of the peptides shown is unknown. {ECO:0000305}.
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DR   AlphaFoldDB; P86681; -.
DR   SMR; P86681; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IDA:UniProtKB.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   GO; GO:0035899; P:negative regulation of blood coagulation in another organism; IDA:UniProtKB.
DR   GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Blood coagulation; Direct protein sequencing; Hemostasis;
KW   Protease inhibitor; Secreted.
FT   CHAIN           1..>90
FT                   /note="Leech factor Xa inhibitor"
FT                   /id="PRO_0000397940"
FT   NON_CONS        34..35
FT                   /evidence="ECO:0000305"
FT   NON_CONS        41..42
FT                   /evidence="ECO:0000305"
FT   NON_CONS        55..56
FT                   /evidence="ECO:0000305"
FT   NON_CONS        70..71
FT                   /evidence="ECO:0000305"
FT   NON_TER         90
SQ   SEQUENCE   90 AA;  10575 MW;  7EC6841BD9CCFC73 CRC64;
     FDVPEPFKWV DHFFYEKLDE QHKGLFFAFF DWGKGPDYWG KDTISLSQEQ VDAKFELDLE
     YGIFYGNGET IENPSENGDL QGIFFSWGSE