LGC50_CAEEL
ID LGC50_CAEEL Reviewed; 491 AA.
AC P41849;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 3.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Ligand-gated ion channel 50;
DE Flags: Precursor;
GN Name=lgc-50; ORFNames=T20B12.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000305}.
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DR EMBL; FO081094; CCD69080.1; -; Genomic_DNA.
DR PIR; T16909; T16909.
DR RefSeq; NP_498637.3; NM_066236.4.
DR AlphaFoldDB; P41849; -.
DR SMR; P41849; -.
DR BioGRID; 53293; 2.
DR STRING; 6239.T20B12.9; -.
DR EPD; P41849; -.
DR PaxDb; P41849; -.
DR PeptideAtlas; P41849; -.
DR EnsemblMetazoa; T20B12.9.1; T20B12.9.1; WBGene00020605.
DR GeneID; 188633; -.
DR KEGG; cel:CELE_T20B12.9; -.
DR CTD; 188633; -.
DR WormBase; T20B12.9; CE46014; WBGene00020605; lgc-50.
DR eggNOG; KOG3644; Eukaryota.
DR HOGENOM; CLU_010920_1_3_1; -.
DR InParanoid; P41849; -.
DR OMA; YDTHLLP; -.
DR OrthoDB; 466513at2759; -.
DR PhylomeDB; P41849; -.
DR Reactome; R-CEL-977443; GABA receptor activation.
DR PRO; PR:P41849; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00020605; Expressed in larva and 3 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..491
FT /note="Ligand-gated ion channel 50"
FT /id="PRO_0000076981"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 418
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 157..171
FT /evidence="ECO:0000250"
SQ SEQUENCE 491 AA; 56200 MW; 446B254DCF62ED42 CRC64;
MRFLLVLQLV FFYFSAATTN SPKKCSRNSI NLGKLIDTLL TDYDTHLLPE AEGVNVTIEL
HVQGVSGISE ITGDFSLDVM YSEIWQDPRL SFKHLNVCAT NITLKSDFRK KIWTPDTCII
NSKSSSIHSS PSENTFVILY ENGLVWSNFR LNVKTPCSVN LKMFPFDSLS CEIVLESYSF
NTDEVRLMWH DVPITMMEKV ELPDFDLIGW STDHQRLEYP NGIWDRAKVK FTFARRYGFY
LFQSYFPTSL TVISSWVGFF FDVRSVSARI TLGVSSLLAL TFQFGNVLRH LPRVSYIKCL
DVWMIFSVIF IFCTLVELAI VCQLNRWERE RQIGSKVLGH WLNQIRKTRK KESKADEGGG
GGVGGLLRKR IPVLAQLKAA ATDSNSGAAT AMTTAIQPPN TNLNSITNSD NSKLVANNFT
SIEHETYAYE KKRGFSHCFQ RFVYAICPPD RDWTITSVQV DRCSMIMFPL SFLIFNVVYW
SIYFMKMDRP M
