ID   LGE1_ASHGO              Reviewed;         244 AA.
AC   Q75A59;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Transcriptional regulatory protein LGE1;
GN   Name=LGE1; OrderedLocusNames=ADR060C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in transcriptional activation. Also required for
CC       ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a
CC       specific tag for epigenetic transcriptional activation, telomeric
CC       silencing, and is also a prerequisite for H3K4me and H3K79me formation.
CC       Its precise role in H2BK123ub1 formation however is unclear (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AE016817; AAS51980.1; -; Genomic_DNA.
DR   RefSeq; NP_984156.1; NM_209509.1.
DR   AlphaFoldDB; Q75A59; -.
DR   STRING; 33169.AAS51980; -.
DR   EnsemblFungi; AAS51980; AAS51980; AGOS_ADR060C.
DR   GeneID; 4620305; -.
DR   KEGG; ago:AGOS_ADR060C; -.
DR   eggNOG; ENOG502SA4A; Eukaryota.
DR   HOGENOM; CLU_1137773_0_0_1; -.
DR   InParanoid; Q75A59; -.
DR   OMA; NNPWINI; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Coiled coil; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..244
FT                   /note="Transcriptional regulatory protein LGE1"
FT                   /id="PRO_0000076231"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..31
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   244 AA;  26264 MW;  DBBB3475C67DC7A6 CRC64;
     MSFSGEHPGN ANNEGPPPPP PPPPPPSHSS APPSSQGGSA RAAPLNGAFH SHQPHSQGYA
     RAEGSNGYRQ PYGRGGYRGS GGRYYGGYGY GHGGGGYGYG HGGGGNYGHG HHGYYGYQGE
     YRGHSGYQRF NSPAPVGTRY SGAAGPAARP PPPPEPEPEQ PFELTDDPLF HLTELDRSTD
     DPRQLDEMRR IFKDSVQLDQ KLEQQKLAMW RTELELSLLD TQSAKDALNV QLNQENLDAL
     LMQG