ID   LGE1_CANGA              Reviewed;         313 AA.
AC   Q6FJC7;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Transcriptional regulatory protein LGE1;
GN   Name=LGE1; OrderedLocusNames=CAGL0M07337g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in transcriptional activation. Also required for
CC       ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a
CC       specific tag for epigenetic transcriptional activation, telomeric
CC       silencing, and is also a prerequisite for H3K4me and H3K79me formation.
CC       Its precise role in H2BK123ub1 formation however is unclear (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR380959; CAG62643.1; -; Genomic_DNA.
DR   RefSeq; XP_449667.1; XM_449667.1.
DR   AlphaFoldDB; Q6FJC7; -.
DR   STRING; 5478.XP_449667.1; -.
DR   EnsemblFungi; CAG62643; CAG62643; CAGL0M07337g.
DR   GeneID; 2891716; -.
DR   KEGG; cgr:CAGL0M07337g; -.
DR   CGD; CAL0136585; CAGL0M07337g.
DR   VEuPathDB; FungiDB:CAGL0M07337g; -.
DR   eggNOG; ENOG502SA4A; Eukaryota.
DR   HOGENOM; CLU_888515_0_0_1; -.
DR   InParanoid; Q6FJC7; -.
DR   OMA; YSANSRH; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Coiled coil; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..313
FT                   /note="Transcriptional regulatory protein LGE1"
FT                   /id="PRO_0000076232"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          83..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..222
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   313 AA;  34425 MW;  BE0A9BD496320FC8 CRC64;
     MSDERYQSRY GRYDSGRGGR SGYYSNYQNS SHHRSNDGPN TNTHGPSNGN GNSGGYYHGY
     YNRHGSMNGR AASSGRGYYG GHNTHITSAP HNNPNAYSRA PATGNTSYTG SYYSRGGNSS
     GRGGYSSYNR GGYHASHQYN NGGYYHRNNN YNSSYTERQK SVSGDSATSG GMKYTSSHRT
     THVTHPAHPP ITIQRSGSNG NGVAQGNASS GEVPTAPRRE TTAQNNGRDK REEQLKKYGI
     SNMAQGYLEI MDQNSSSTTS VTQTEIELDE KLREMNSQVF RTMCELALVE NQYTRDTLNV
     QLTQEKLDTL LLS