ID   LGE1_KLULA              Reviewed;         230 AA.
AC   Q6CVS3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Transcriptional regulatory protein LGE1;
GN   Name=LGE1; OrderedLocusNames=KLLA0B09834g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in transcriptional activation. Also required for
CC       ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a
CC       specific tag for epigenetic transcriptional activation, telomeric
CC       silencing, and is also a prerequisite for H3K4me and H3K79me formation.
CC       Its precise role in H2BK123ub1 formation however is unclear (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR382122; CAH02359.1; -; Genomic_DNA.
DR   RefSeq; XP_451966.1; XM_451966.1.
DR   AlphaFoldDB; Q6CVS3; -.
DR   SMR; Q6CVS3; -.
DR   STRING; 28985.XP_451966.1; -.
DR   EnsemblFungi; CAH02359; CAH02359; KLLA0_B09834g.
DR   GeneID; 2897486; -.
DR   KEGG; kla:KLLA0_B09834g; -.
DR   eggNOG; ENOG502SA4A; Eukaryota.
DR   HOGENOM; CLU_1321715_0_0_1; -.
DR   InParanoid; Q6CVS3; -.
DR   OMA; NNPWINI; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Coiled coil; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..230
FT                   /note="Transcriptional regulatory protein LGE1"
FT                   /id="PRO_0000076233"
FT   REGION          1..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          172..203
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..103
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   230 AA;  26070 MW;  5BB825AB686719C1 CRC64;
     MSEPNEGGSS YRSGGNYNGY KPSGNRYQPN SNNRGPPRYR SNHRQDGGYY NNGGYHQQQG
     YGYGQPTHAH GVQRQTYRGG SYHPYQHSDS RYGSNSTYRR PYGQQSVPPA PPPSTASSVS
     SSSAYSRGSN VLPVSRNSYP SPKYEQPKKK FTIPKDENPF IYMMSNDDHS RTSKLKEVYK
     ENDQIDNKLE ELKLKIFKDE LELGLMSTQC EKDALNVQLT QEKLDSLLMN