ID   LGEN_BOVIN              Reviewed;          73 AA.
AC   P59761;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Lactogenin;
DE            EC=3.1.27.-;
DE   Flags: Fragments;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND CHARACTERIZATION.
RC   TISSUE=Milk;
RX   PubMed=10486275; DOI=10.1006/bbrc.1999.1091;
RA   Ye X.Y., Cheng K.J., Ng T.B.;
RT   "Isolation and characterization of angiogenin-1 and a novel protein
RT   designated lactogenin from bovine milk.";
RL   Biochem. Biophys. Res. Commun. 263:187-191(1999).
RN   [2]
RP   INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE.
RX   PubMed=11105990; DOI=10.1016/s0024-3205(00)00853-5;
RA   Wang H., Ye X.Y., Ng T.B.;
RT   "First demonstration of an inhibitory activity of milk proteins against
RT   human immunodeficiency virus-1 reverse transcriptase and the effect of
RT   succinylation.";
RL   Life Sci. 67:2745-2752(2000).
CC   -!- FUNCTION: Secretory RNase specific towards pyrimidine bases, with
CC       higher activity towards poly C than poly U. Inhibits cell-free
CC       translation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Milk.
CC   -!- MISCELLANEOUS: Inhibits HIV-1 reverse transcriptase in vitro.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P59761; -.
DR   SMR; P59761; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0050691; P:regulation of defense response to virus by host; NAS:UniProtKB.
DR   Gene3D; 3.10.130.10; -; 1.
DR   InterPro; IPR001427; RNaseA.
DR   InterPro; IPR036816; RNaseA-like_dom_sf.
DR   PANTHER; PTHR11437; PTHR11437; 1.
DR   SUPFAM; SSF54076; SSF54076; 1.
PE   1: Evidence at protein level;
KW   Antiviral protein; Direct protein sequencing; Endonuclease; Hydrolase;
KW   Nuclease; Pyrrolidone carboxylic acid; Reference proteome; Secreted.
FT   CHAIN           1..>73
FT                   /note="Lactogenin"
FT                   /id="PRO_0000057218"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:10486275"
FT   UNSURE          36
FT                   /note="N or R"
FT   UNSURE          37
FT                   /note="R or E"
FT   UNSURE          38
FT                   /note="H or Q"
FT   UNSURE          39
FT                   /note="E or C"
FT   UNSURE          40
FT                   /note="G or R"
FT   UNSURE          41
FT                   /note="V or N"
FT   UNSURE          42
FT                   /note="R or C"
FT   UNSURE          43
FT                   /note="F or N"
FT   NON_CONS        57..58
FT                   /evidence="ECO:0000305"
FT   NON_TER         73
SQ   SEQUENCE   73 AA;  8669 MW;  28DA862F43A8710F CRC64;
     QGRMYQRFLR QHVDPDETGG NDHYLNLSRR NIQCPNRHEG VRFNTDIHED LTNRRPIDEH
     EGVVRVTDKT EEG