ID   LGI2_PANTR              Reviewed;         545 AA.
AC   Q1EGL1;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Leucine-rich repeat LGI family member 2;
DE   AltName: Full=Leucine-rich glioma-inactivated protein 2;
DE   Flags: Precursor;
GN   Name=LGI2;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gu W., Gilbert Y., Freudenberg J., Elischer A., Bloch W., Meyer A.,
RA   Steinlein O., Begemann G.;
RT   "The evolution of the LGI family.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the development of soma-targeting inhibitory
CC       GABAergic synapses made by parvalbumin-positive basket cells.
CC       {ECO:0000250|UniProtKB:Q8K4Z0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; AY615299; AAV49151.1; -; mRNA.
DR   RefSeq; NP_001037843.1; NM_001044378.1.
DR   AlphaFoldDB; Q1EGL1; -.
DR   SMR; Q1EGL1; -.
DR   STRING; 9598.ENSPTRP00000027477; -.
DR   PaxDb; Q1EGL1; -.
DR   Ensembl; ENSPTRT00000078744; ENSPTRP00000089349; ENSPTRG00000045126.
DR   GeneID; 471159; -.
DR   KEGG; ptr:471159; -.
DR   CTD; 55203; -.
DR   VGNC; VGNC:13016; LGI2.
DR   eggNOG; ENOG502QR53; Eukaryota.
DR   GeneTree; ENSGT00940000157294; -.
DR   HOGENOM; CLU_036403_0_0_1; -.
DR   InParanoid; Q1EGL1; -.
DR   OMA; QDIEVTK; -.
DR   OrthoDB; 365688at2759; -.
DR   TreeFam; TF333155; -.
DR   Proteomes; UP000002277; Chromosome 4.
DR   Bgee; ENSPTRG00000045126; Expressed in colon and 11 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:1904862; P:inhibitory synapse assembly; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR009039; EAR.
DR   InterPro; IPR005492; EPTP.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF03736; EPTP; 6.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00082; LRRCT; 1.
DR   PROSITE; PS50912; EAR; 7.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Leucine-rich repeat; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..545
FT                   /note="Leucine-rich repeat LGI family member 2"
FT                   /id="PRO_0000251157"
FT   DOMAIN          29..65
FT                   /note="LRRNT"
FT   REPEAT          86..107
FT                   /note="LRR 1"
FT   REPEAT          110..131
FT                   /note="LRR 2"
FT   REPEAT          134..155
FT                   /note="LRR 3"
FT   DOMAIN          167..217
FT                   /note="LRRCT"
FT   REPEAT          219..261
FT                   /note="EAR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          265..307
FT                   /note="EAR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          311..358
FT                   /note="EAR 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          360..403
FT                   /note="EAR 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          407..450
FT                   /note="EAR 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          452..494
FT                   /note="EAR 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          498..540
FT                   /note="EAR 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        186
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        271
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        402
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   545 AA;  62298 MW;  FD29B51F01B3D7E2 CRC64;
     MALRRGGCGA LGLLLLLLGA ACLIPRSAQV RRLARCPATC SCTKESIICV GSSWVPRIVP
     GDISSLSLVN GTFSEIKDRM FSHLPSLQLL LLNSNSFTII RDDAFAGLFH LEYLFIEGNK
     IETISRNAFR GLRDLTHLSL ANNHIKALPR DVFSDLDSLI ELDLRGNKFE CDCKAKWLYL
     WLKMTNSTVS DVLCIGPPEY QEKKLNDVTS FDYECTTTDF VVHQTLPYQS VSVDTFNSKN
     DVYVAIAQPS MENCMVLEWD HIEMNFRSYD NITGQSIVGC KAILIDDQVF VVVAQLFGGS
     HIYKYDESWT KFVKFQDIEV SRISKPNDIE LFQIDDETFF VIADSSKAGL STVYKWNSKG
     FYSYQSLHEW FRDTDAEFVD IDGKSHLILS SRSQVPIILQ WNKSSKKFVP HGDIPNMEDV
     LAVKSFRMQN TLYLSLTRFI GDSRVMRWNS KQFVEIQALP SRGAMTLQPF SFKDNHYLAL
     GSDYTFSQIY QWDKEKQLFK KFKEIYVQAP RSFTAVSTDR RDFFFASSFK GKTKIFEHII
     VDLSL