ID   LGI3_MACFA              Reviewed;         548 AA.
AC   Q4R4H3;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Leucine-rich repeat LGI family member 3;
DE   AltName: Full=Leucine-rich glioma-inactivated protein 3;
DE   Flags: Precursor;
GN   Name=LGI3; ORFNames=QccE-10939;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May participate in the regulation of neuronal exocytosis.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STX1A. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Cytoplasmic vesicle,
CC       secretory vesicle, synaptic vesicle {ECO:0000250}. Synapse, synaptosome
CC       {ECO:0000250}. Note=Found in the synaptosomal membrane fraction.
CC       {ECO:0000250}.
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DR   EMBL; AB169921; BAE02002.1; -; mRNA.
DR   RefSeq; NP_001306384.1; NM_001319455.1.
DR   AlphaFoldDB; Q4R4H3; -.
DR   SMR; Q4R4H3; -.
DR   STRING; 9541.XP_005562831.1; -.
DR   GeneID; 102115818; -.
DR   CTD; 203190; -.
DR   eggNOG; ENOG502QSAR; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR   GO; GO:0008021; C:synaptic vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR009039; EAR.
DR   InterPro; IPR005492; EPTP.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR   Pfam; PF03736; EPTP; 7.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF50952; SSF50952; 1.
DR   PROSITE; PS50912; EAR; 7.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Exocytosis; Glycoprotein; Leucine-rich repeat;
KW   Reference proteome; Repeat; Secreted; Signal; Synapse; Synaptosome.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..548
FT                   /note="Leucine-rich repeat LGI family member 3"
FT                   /id="PRO_0000251158"
FT   DOMAIN          31..64
FT                   /note="LRRNT"
FT   REPEAT          89..110
FT                   /note="LRR 1"
FT   REPEAT          113..134
FT                   /note="LRR 2"
FT   REPEAT          137..158
FT                   /note="LRR 3"
FT   DOMAIN          170..220
FT                   /note="LRRCT"
FT   REPEAT          222..264
FT                   /note="EAR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          268..310
FT                   /note="EAR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          314..361
FT                   /note="EAR 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          363..406
FT                   /note="EAR 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          410..453
FT                   /note="EAR 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          455..497
FT                   /note="EAR 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          501..543
FT                   /note="EAR 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        311
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        394
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   548 AA;  61874 MW;  228DE6DD6A2434DC CRC64;
     MAGLRARRGP APGLLALSAL GFCLMLQVSA KRLPKTPPCP PSCSCTRDTA FCVDSKAVPR
     NLPSEVISLT LVNAAFSEIH DGAFSHLPLL QFLLLNSNKF TLIGDNAFTG LSHLQYLFIE
     NNDIWTLSKF TFRGLKSLTH LSLANNNLQT LPRDIFRPLD ILNDLDLRGN SLNCDCKVKW
     LVEWLAHTNT TVAPIYCASP PRFQEHKVQD LPLREFDCIT TDFVLYQTLS FPAVSAEPFL
     YSSDLYLALA QPGVSACTIL KWDYVERQLR DYDRIPAPSA VHCKPMVVDS QLYVVVAQLF
     GGSYIYHWDP NTTRFTKLQD IDPQRVRKPN DLEAFRIDGD WYFAVADSSK AGATSLYRWH
     QNGFYSHQAL HPWHRDTDLE FVDGEGKPRL IVSNSSQAPV IYQWSRTQKQ FVAQGEVTQV
     PDAQAVKHFR AGRDSYLCLS RYIGDSKILR WEGTRFSEVQ ALPSRGSLAL QPFLVGGRRY
     LALGSDFSFT QIYQWDEGRQ KFVRFQELAV QAPRAFCYMP AGDAQLLLAP SFKGQTLVYR
     HVVVDLSA