ID   LGI3_PANTR              Reviewed;         548 AA.
AC   Q1EGL0;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Leucine-rich repeat LGI family member 3;
DE   AltName: Full=Leucine-rich glioma-inactivated protein 3;
DE   Flags: Precursor;
GN   Name=LGI3;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gu W., Gilbert Y., Freudenberg J., Elischer A., Bloch W., Meyer A.,
RA   Steinlein O., Begemann G.;
RT   "The evolution of the LGI family.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May participate in the regulation of neuronal exocytosis.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STX1A. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Cytoplasmic vesicle,
CC       secretory vesicle, synaptic vesicle {ECO:0000250}. Synapse, synaptosome
CC       {ECO:0000250}. Note=Found in the synaptosomal membrane fraction.
CC       {ECO:0000250}.
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DR   EMBL; AY615300; AAV49152.1; -; mRNA.
DR   RefSeq; NP_001065284.1; NM_001071816.1.
DR   AlphaFoldDB; Q1EGL0; -.
DR   SMR; Q1EGL0; -.
DR   STRING; 9598.ENSPTRP00000054912; -.
DR   PaxDb; Q1EGL0; -.
DR   Ensembl; ENSPTRT00000062356; ENSPTRP00000054912; ENSPTRG00000020052.
DR   GeneID; 742072; -.
DR   KEGG; ptr:742072; -.
DR   CTD; 203190; -.
DR   VGNC; VGNC:6569; LGI3.
DR   eggNOG; ENOG502QSAR; Eukaryota.
DR   GeneTree; ENSGT00940000160296; -.
DR   HOGENOM; CLU_036403_0_0_1; -.
DR   InParanoid; Q1EGL0; -.
DR   OMA; NSNTFTM; -.
DR   OrthoDB; 365688at2759; -.
DR   TreeFam; TF333155; -.
DR   Proteomes; UP000002277; Chromosome 8.
DR   Bgee; ENSPTRG00000020052; Expressed in dorsolateral prefrontal cortex and 10 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0017157; P:regulation of exocytosis; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR009039; EAR.
DR   InterPro; IPR005492; EPTP.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR   Pfam; PF03736; EPTP; 7.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF50952; SSF50952; 1.
DR   PROSITE; PS50912; EAR; 7.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Exocytosis; Glycoprotein; Leucine-rich repeat;
KW   Reference proteome; Repeat; Secreted; Signal; Synapse; Synaptosome.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..548
FT                   /note="Leucine-rich repeat LGI family member 3"
FT                   /id="PRO_0000251159"
FT   DOMAIN          31..64
FT                   /note="LRRNT"
FT   REPEAT          89..110
FT                   /note="LRR 1"
FT   REPEAT          113..134
FT                   /note="LRR 2"
FT   REPEAT          137..158
FT                   /note="LRR 3"
FT   DOMAIN          170..220
FT                   /note="LRRCT"
FT   REPEAT          222..264
FT                   /note="EAR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          268..310
FT                   /note="EAR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          314..361
FT                   /note="EAR 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          363..406
FT                   /note="EAR 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          410..453
FT                   /note="EAR 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          455..497
FT                   /note="EAR 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   REPEAT          501..543
FT                   /note="EAR 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00075"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        311
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   548 AA;  61706 MW;  9318079EFB8A468F CRC64;
     MAGLRARGGP GPGLLALSAL GFCLMLQVSA KRPPKTPPCP PSCSCTRDTA FCVDSKAVPR
     NLPSEVISLT LVNAAFSEIQ DGAFSHLPLL QFLLLNSNKF TLIGDNAFTG LSHLQYLFIE
     NNDIWALSKF TFRGLKSLTH LSLANNNLQT LPRDIFRPLD ILNDLDLRGN SLNCDCKVKW
     LVEWLAHTNT TVAPIYCASP PRFQEHKVQD LPLREFDCIT TDFVLYQTLS FPAVSAEPFL
     YSSDLYLALA QPGVSACTIL KWDYVERQLR DYDRIPAPSA VHCKPMVVDS QLYVVVAQLF
     GGSYIYHWDP NTTRFTRLQD IDPQRVRKPN DLEAFRIDGD WYFAVADSSK AGATSLYRWH
     QNGFYSHQAL HPWHRDTDLE FVDGEGKPRL IVSSSSQAPV IYQWSRTQKQ FVAQGEVTQV
     PDAQAVKHFR AGRDSYLCLS RYIGDSKILR WEGTRFSEVQ ALPSRGSLAL QPFLVGGRRY
     LALGSDFSFT QIYQWDEGRQ KFVRFQELAV QAPRAFCYMP AGDAQLLLAP SFKGQTLVYR
     HVVVDLSA