LGOR_ECOLI
ID LGOR_ECOLI Reviewed; 304 AA.
AC P39399; Q2M5V9; Q6BEW6;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Probable HTH-type transcriptional regulator LgoR;
GN Name=lgoR; Synonyms=yjjM; OrderedLocusNames=b4357, JW5792;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP SEQUENCE REVISION.
RX PubMed=16397293; DOI=10.1093/nar/gkj405;
RA Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R.,
RA Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T.,
RA Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H.,
RA Thomson N.R., Wishart D., Wanner B.L.;
RT "Escherichia coli K-12: a cooperatively developed annotation snapshot
RT -- 2005.";
RL Nucleic Acids Res. 34:1-9(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP FUNCTION, ROLE IN L-GALACTONATE UTILIZATION, DISRUPTION PHENOTYPE, AND
RP INDUCTION.
RX PubMed=17088549; DOI=10.1073/pnas.0603364103;
RA Reed J.L., Patel T.R., Chen K.H., Joyce A.R., Applebee M.K., Herring C.D.,
RA Bui O.T., Knight E.M., Fong S.S., Palsson B.O.;
RT "Systems approach to refining genome annotation.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:17480-17484(2006).
CC -!- FUNCTION: May be a positive transcriptional regulator for lgoD and/or
CC lgoT. Is essential for growth on L-galactonate as the sole carbon
CC source. {ECO:0000269|PubMed:17088549}.
CC -!- INDUCTION: Highly up-regulated during growth on L-galactonate.
CC {ECO:0000269|PubMed:17088549}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene fail to grow on L-
CC galactonate as sole carbon source. {ECO:0000269|PubMed:17088549}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA97255.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U14003; AAA97255.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00096; AAT48248.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78347.1; -; Genomic_DNA.
DR PIR; S56584; S56584.
DR RefSeq; WP_000091570.1; NZ_LN832404.1.
DR RefSeq; YP_026290.1; NC_000913.3.
DR AlphaFoldDB; P39399; -.
DR SMR; P39399; -.
DR BioGRID; 4261391; 99.
DR STRING; 511145.b4357; -.
DR PaxDb; P39399; -.
DR PRIDE; P39399; -.
DR EnsemblBacteria; AAT48248; AAT48248; b4357.
DR EnsemblBacteria; BAE78347; BAE78347; BAE78347.
DR GeneID; 948881; -.
DR KEGG; ecj:JW5792; -.
DR KEGG; eco:b4357; -.
DR PATRIC; fig|1411691.4.peg.2329; -.
DR EchoBASE; EB2474; -.
DR eggNOG; COG1802; Bacteria.
DR HOGENOM; CLU_082415_0_0_6; -.
DR OMA; REMFELH; -.
DR PhylomeDB; P39399; -.
DR BioCyc; EcoCyc:G7944-MON; -.
DR PRO; PR:P39399; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0019584; P:galactonate catabolic process; IMP:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:EcoCyc.
DR Gene3D; 1.10.10.10; -; 2.
DR Gene3D; 1.20.120.530; -; 1.
DR InterPro; IPR011711; GntR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF07729; FCD; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00895; FCD; 1.
DR SUPFAM; SSF46785; SSF46785; 2.
DR SUPFAM; SSF48008; SSF48008; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..304
FT /note="Probable HTH-type transcriptional regulator LgoR"
FT /id="PRO_0000169810"
FT DOMAIN 1..70
FT /note="HTH gntR-type"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT CONFLICT 56
FT /note="G -> A (in Ref. 1; AAA97255)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 304 AA; 35397 MW; A41399D07F0DA9C7 CRC64;
MSRSQNLRHN VINQVIDDMA RGHIPSPLPS QSALAEMYNI SRTTVRHILS HLRECGVLTQ
VGNDYVIARK PDHDDGFACT TASMSEQNKV FEQAFFTMIN QRQLRPGETF SELQLARAAG
VSPVVVREYL LKFGRYNLIH SEKRGQWSMK QFDQSYAEQL FELREMLETH SLQHFLNLPD
HDPRWLQAKT MLERHRLLRD NIGNSFRMFS QLDRDFHSLL LSAADNIFFD QSLEIISVIF
HFHYQWDESD LKQRNIIAVD EHMTILSALI CRSDLDATLA LRNHLNSAKQ SMIRSINENT
RYAH
