LGRC_BREPA
ID LGRC_BREPA Reviewed; 7756 AA.
AC Q70LM5;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Linear gramicidin synthase subunit C;
DE Includes:
DE RecName: Full=ATP-dependent valine adenylase;
DE Short=ValA;
DE AltName: Full=Valine activase;
DE Includes:
DE RecName: Full=ATP-dependent D-valine adenylase;
DE Short=D-ValA;
DE AltName: Full=D-valine activase;
DE Includes:
DE RecName: Full=Valine racemase [ATP-hydrolyzing];
DE EC=5.1.1.-;
DE Includes:
DE RecName: Full=ATP-dependent tryptophan adenylase;
DE Short=TrpA;
DE AltName: Full=Tryptophan activase;
DE Includes:
DE RecName: Full=ATP-dependent tryptophan/phenylalanine/tyrosine adenylase;
DE Short=Trp/Phe/TyrA;
DE AltName: Full=Tryptophan/phenylalanine/tyrosine activase;
GN Name=lgrC;
OS Brevibacillus parabrevis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX NCBI_TaxID=54914;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 8185 / DSM 362 / JCM 20017 / NBRC 3331 / NCDO 717 / NCIMB 8598
RC / IAM 1031;
RX PubMed=14670971; DOI=10.1074/jbc.m309658200;
RA Kessler N., Schuhmann H., Morneweg S., Linne U., Marahiel M.A.;
RT "The linear pentadecapeptide gramicidin is assembled by four multimodular
RT nonribosomal peptide synthetases that comprise 16 modules with 57 catalytic
RT domains.";
RL J. Biol. Chem. 279:7413-7419(2004).
CC -!- FUNCTION: Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-
CC Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of
CC the peptide bond between them. This enzyme is also responsible for the
CC epimerization of the 8th (D-Val), the 10th (D-Leu) and 12th (D-Leu)
CC amino acids. The 11th (Xaa) amino acid is Trp in linear gramicidin A;
CC Phe in linear gramicidin B and Tyr in linear gramicidin C.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000305};
CC Note=Binds 6 phosphopantetheines covalently. {ECO:0000305};
CC -!- SUBUNIT: Large multienzyme complex composed of 4 subunits; LgrA, LgrB,
CC LgrC and LgrD.
CC -!- DOMAIN: Six module-bearing peptide synthase with a C-terminal
CC epimerization domain. Each module incorporates one amino acid into the
CC peptide product and can be further subdivided into domains responsible
CC for substrate adenylation, thiolation, condensation (not for the
CC initiation module), and epimerization (optional).
CC -!- MISCELLANEOUS: Linear gramicidin is a pentadecapeptide antibiotic
CC produced during sporulation.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000305}.
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DR EMBL; AJ566197; CAD92851.1; -; Genomic_DNA.
DR SMR; Q70LM5; -.
DR PRIDE; Q70LM5; -.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR Gene3D; 1.10.1200.10; -; 6.
DR Gene3D; 3.30.300.30; -; 6.
DR Gene3D; 3.30.559.10; -; 9.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR Pfam; PF00501; AMP-binding; 6.
DR Pfam; PF13193; AMP-binding_C; 6.
DR Pfam; PF00668; Condensation; 9.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00823; PKS_PP; 6.
DR SUPFAM; SSF47336; SSF47336; 6.
DR TIGRFAMs; TIGR01733; AA-adenyl-dom; 6.
DR TIGRFAMs; TIGR01720; NRPS-para261; 3.
DR PROSITE; PS00455; AMP_BINDING; 6.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis; Isomerase; Ligase; Multifunctional enzyme;
KW Phosphopantetheine; Phosphoprotein; Repeat.
FT CHAIN 1..7756
FT /note="Linear gramicidin synthase subunit C"
FT /id="PRO_0000193091"
FT DOMAIN 977..1052
FT /note="Carrier 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT DOMAIN 2042..2116
FT /note="Carrier 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT DOMAIN 3557..3632
FT /note="Carrier 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT DOMAIN 4621..4695
FT /note="Carrier 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT DOMAIN 6141..6216
FT /note="Carrier 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT DOMAIN 7200..7274
FT /note="Carrier 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 1012
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 2077
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 3592
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 4656
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 6176
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT MOD_RES 7235
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ SEQUENCE 7756 AA; 866321 MW; C0EA2EAB6AAC5C7B CRC64;
MNSMGDLTDL YTLTPLQEGM LFHSLYSEGS AYMIQTTAIL TGELDIVPFE KAWKKVIQRH
SILRTGFIWE ETEKPLQAVF ESVPFSIRQK DWSSYGSDEQ ESMLAAFLQN EKAAGFDLSE
APLMRVTIIK LGEAVHRLIW SFHHLLLDGW SSPIVFQEVL DFYEAYRQGK DLRLPQARPF
KDYVSWLRRQ DKTASEQFWR EFLGPMENPT PIPFETHAKR TAGHEGLEKQ IGEATRALTG
QVTKALAKLA RTNKVTVNTI VQGAWAILLS RLSGEENVVY GVTGSGRPSD LPGVEQMVGM
FINTLPMKAK IEPEQSLADW FKALQEQQSK VRQYEYTSLV DIQGWTDVPR GTPLFESIFV
FENYPLGEED EKEVGFTISA VQHFQEVDNP LTVVGIPGDP FSIKMMYATD RFEQAAIERT
LDQLALILEA IVDNPERSLS ALSLLRPEER QHLLVGLNDT ATNYPSDKTV HQLFAETAAR
HPERIAAVAG DQQLTYAELE ARANQLANYL QKQGVEAGTL VGLCVDRSLD MLIGLLAILK
AGGAYVPIDP AYPEERLAFM LADAKISILL TQKHLGKQWK GRKRRTVYLD RDAKKWAEES
PLAPDVDTTK DSLAYVIYTS GSTGTPKGVL AVHRGVVRLG QKTRTTSPIS EADVFLQAST
VSFDAATFEI WGALLNGAKL VLMPPDLPSL DELGEAIVQH KVTTLWLTAG LFSIMVDHNA
DYLRGVRQLL VGGDVVSVPH VRKVLALGGV TVINGYGPTE NTTFTCCYPV TELSEDITSF
PIGRPISNTT VYVLDKHKQP VPYGAAGELY IGGDGLALGY LNNAELTAER FVENPFDPQK
GSRLYRTGDL VRYLPNGTIE FIGRIDNQVK IRGFRIELGE VEAALALHPE VSETVVMARE
NDRGEKHLTA YVTVAKDDAP EVADLQAWLK TKLPEYMVPS AYVFLDAMPL TANGKIDRRR
LPEPEWGNRS ETKAYTEPRN QAEELIASIW SQVLGVEKVG IHDNFFELGG HSLLATRVIS
RLREVFGVEQ SVRSIFEHPT IDAWSEQTAA LQLGGPGTDD SSTQIQPVPR DGALPLSFAQ
QRLWFFDQLM PDNPMYNIPF ALRLQGELDV AAWEKSLQAI IARHESLRTT FTDIDGQAVQ
VIHPQLDWKL DTVDLRDRSS EEKQQASARL AADDAARPFD LRQGPLMRAT MIRTEEQAHV
FLINMHHIVS DGWSVGVFLR ELFAHYEAYS KGEVPQLAPM PIQYADFAAW QREWLEGEVL
EQQVAYWKEK LGGAEPLLAL PTDRPRPALQ SYEGATYTTS FSHDLLAKLK KLSKEAQHDL
VHDIARRFPN VLYRYSGQED IVVGSPVAGR NRQETEKLIG FFVNTLALRT SLSGDLPFTE
LLARVRETAL AAYAHQDVPF EKLVDELQLE RSLSYSQLFQ VMFVLQNFPL EDVETAGLHV
APVDTESHLT TSKFDLTLTM REKEDTLVAA FEYSTDLFDR TTIERMAEHL QHLLASIVTQ
PEASLDQLAL LGESEWNRLV VEQNETATDY PRDKTAHQLF AETAARYPER IAAVAGDQQL
TYAELDTKAN QLANYLQKQG VEAGTLVGLC VDRSLDMLVG LLAILKAGGA YVPLDPAYPE
ERLAFMLADA NVSILLTQKH LGKQWKGRKR RTVYLDRDAK KWTAESPLAP AVDATKDSLA
YVIYTSGSTG TPKGVLVAHR GIVRLVKNTN YVTITEEDVF LQASTVSFDA ATFEIWGALL
NGAKLVLMPP DLPSLDELGE AIVQHKVTTL WLTAGLFSIM VDHNADYLRG VRQLLVGGDV
VSVPHVRKVL ALDGVTVING YGPTENTTFT CCYPVTELAE EITSFPIGRP ISNTTVYVLD
KNRQPVPLGV AGELYIGGDG LASGYLNNPE LTAERFVDNP FDPQKASRLY RTGDLVRYLP
DGAIEFIGRI DNQVKIRGFR IELGEIETAL LRHPAVQEAF LMVREDAPGD KRLAAYLVFA
GGQTVEPVEM RSYLKDKLPE YMIPSAFVQM DSFPLTPNGK VDRRALPTPE YARSEAASGY
VAPATELEVK LADIWKTVLG VADVGIHDNF FELGGDSILS IQIVARANQL GIRLTPKQLF
ENQTIAELLR VVADSSQLPH TKWENEQGIV TGNVPLTPIQ KWFFAADQPS LHHWNQSLLL
TVQQPVDVSV LERAIASLLS HHDALRMSFS FVDGAWTQQM NGLGDHTPFR CVDLSDLSTQ
EQEQAARLEE IASEVQASLN IAEGNVVQAV YFNLGEQKAG RLLLVVHHLV VDGVSWRILL
EDLQHAYEQL ANHADVSFPA KTTSFKMWAE KLADYADSDA LEQEKAYWLQ QSSGGSPLPV
DHPYEPNENT EAAAKQVTLS LRADETRALL HETLTAYRLQ INDVLLAALA KAMQRWTGQK
TLHVHLEGHG REEIIEGADL SRTVGWFTSM YPVQLDFDQS KPWGHVLKAV KEQLRHIPQK
GIGYGILQYL SNDDEWKEQL QAYTKPEISF NYLGQFDQVV SAGAKFAMAE ESRGANIAAD
AIRAHLIDVN SAISGEQLHI TWMYNANIHN QETIEALARD YMESLREIME HCRSEEAGGY
TPSDFPLARL DQRAIDNYVG RDRSIENVYP LTPLQEGMLF HSLYEHAGGD YVVQFSMTMH
HVEVDVFQQA WQKVVDRHSI LRTSFIWDGV STPHQIVRKH VQVVVDEQDW RHVPADQQKA
EWDAFLEEDR KRSFAITEPP LMRWTLLRIS DTAYRFIWSF HHVLLDGWSV PLVMKDWFAA
YMALADGKDI QFGAVHPFSQ YVAWIQRQDL QAAERFWRNH LKGIYAPTQV NFGQTVQPVG
ETKSYDERSI RFSAERTREL QAFARQHQVT LNTLVQSAWA MILGTYSKEA DVVFGATGSG
RPADLPGVEN MVGLFINTLP IRVTLDPGKK VREWLRELQE LQVELRQYEY TPLVDIHGWS
EMARNAPLFE SIFIFENYPI DESVKEVDHS FQIADVDSVE QTNYPLTVVC GPGAEFLVKI
KFDQSRFDGG RIERVLEQMT LLLQSMTANP DQLLADVNMI SQSEQKQVLI EWNETKVDYP
TGLCVQQAFE QQVEKTPDAV ALIYKDVELT YADLNQRANQ LAHRLLAQEV KPDTLVGICV
ERSPEMIIGI FGVMKAGAAY VPIDPALPQE RIAYMVEDSQ ASILLTQQSL AELLPKTQAR
VICLDGDSLA NEPVANPASE VTEQNLAYVM YTSGSTGLPK GVMVEHHSVV NLAHALIEAF
RIQPSSRVLQ FTSFSFDVSV SEIVMALLAG AALVIEDREV LLPGPELISV LQQKRITTVS
MVSSVLAALP AADLPDLQTL IVGGEAPSRE LVARYADRRQ FFNCYGPTEA TVCSTMMLCN
AGMKSAPIGR PLANATLYVL DANQKPVPVG VPGELYIGGK GLARGYWNRP ELTAERFIAH
PFGAKGERLY RTGDLVRYLP DGNLEFLGRI DTQVKIRGYR IELGEIESAL SQHPAIQEAV
VIAWEQRLAA YMVAAGEAQP AAEELARYLK ETLPDYMIPA GFVFMDAIPL TVNGKVDRRA
LPAPDWGILA TRQEYVAPRT PTEEMVANIW AQLLSVEKIG VHDDFFERGG HSLLATQAIS
RLRQAFGVEL PLRMLFDHPT TAAISTQIAS LLQGETALRS QPIVPVPRDQ HVPLSFAQQR
LWFLDRLIPN SFLYNIPSAA RLHGELDVEA WERSLKLLIQ RHESLRTTFS DRDGEAVQII
HPAIEWSLGR VDLREWAEAE REAKALQLAI EDAKRPFDLE RGPLLRASLL VMAQQEYVFL
LNLHHIVADG WSMNVFMEEL VTIYEALSAG ETPQLAELPL QYADYAAWQR DWLQGDVLEQ
QLAYWKAKVG GAEPLLALPT DRPRPAVQSH KGAMHTITLP AERLAALKTL SREEGSTLFM
TLLAAFQTLL YRYSGQSDIV VGSPVAGRNR QETESLIGFF INTLAMRTDL SGEPTFRDLL
GKVRETALEA YAHQDLPFEK LVDELELERS LSYSPLFQVM FVLQNIPMDA QALSHIRLEP
FHIGQEGVSA KFDITLTTVE LPAGLMATFE YNTDLFDPAT IERMAGHYAN LLAAVSVNPL
QPITAIPLVS DQERKQVLFQ WNDTSVPSER DTCVHEQVAR IAQQLPNQLA VVSDEGQITY
AELDAKANQV ANYLHKQGII SETLVGVCLD RSIDMLVAQL GILKAGGAYV PMDPAYPQER
LAFMMQDAEM PVVLTQEHLL AQLPEARATF LCLDRDWSLI AEESDVAPVI ATNRDNLAYV
IYTSGSTGTP KGVEIEHAAL LNLVSWHQRA YEVGAEDRAT QIAGTAFDAS VWEIWPYLTK
GATLYLPSEE IRLVPEQLRD WLVASGITIS FLPTPLAERL LTLEWPSDAK LRYMLTGGDK
LHDYPPATLP FVLANQYGPT ENAVVATAGI VPAAAGQVSA PSIGRPIDNV QVYVLDEKLQ
PVPIGVAGEL YIAGDSLARG YLHRPDLTRE RFIANPYGQK AGARMYKTGD LVRYLPDGNI
EFIGRADDQV SIRGFRVELG EIETALYSHP AVKETIVLVR EDMPGMKRLV AYIVQREGQE
GQAVQAGDFR SYLKELLPEY MVPAAFVFMA DLPLTPNGKV DRRALPAPDL FNSEADGTYV
APATELEIKL AHIWKNVLGL ADVGIHDNFF ELGGDSILSI QIVSRANQAG IRLTPKQLLA
NQTIAELASV ATVTDESEAT KLPNEQGIVT GDVPLTPIQT WFFASEQPSV HHWNQSLLLT
VQQPVDLAVL ERTIECLLAH HDALRMRYSR TEQGWTQRIE GLPETIPFRS VDLSAFPTTA
EQEMRLEEIA SEVQASLDLT EGPVVQAVYF QLGAEQPGRL LIVAHHLVVD GVSWRILLED
LQTAYEQLAK GQAVQLAAKT TSFKTWAEQL RLYATSEALR QEKAFWLEQM DEVKPLPIDR
IFEPSENTEA TVKQVMLSLN AEETRALLQD TLSPYRLQIN DVLLAALTKA LHRWTGEQTV
AIHLEGHGRE ELIEGADLSR TVGWFTSLYP VQLSVDPTKP WGDTLKAVKE QLRSIPNKGV
GYGILRYLSE DAELQKRLAE KAQAEISFNY LGQFDQAVVP ESKFGMAQEA RGANVGQQAI
RQHLLDVNSV IAGEQLHVTW MYSENIHEEA TIQQLAHNYL EALREIIAHG QSEAAGGYTP
SDFPLARMDQ RALDKYLGQN RSIENVYPLS PLQGGMLFHS LYEQEGGDYV VQLAMTVEGL
DVEAFEQAWQ KVVDRHSILR TSFIWEGLTE PHQVVRKQVK ACVEKIDLRH LTPDQQKAEL
SEYLAADRRR SFEIAVAPLM RWTLFRLSES AYRFTWSFHH VLLDGWSIPI VLKDWFSAYL
SLAEGKEVAH SFVQPFAHYV EWVQRQDLQA AEQFWREQLA GFYEPTPLAM GNSTGGRADL
PKGYEEQEIR LAKDATARLQ AFVRTHQLTL NTLVQGAWAL MLGRYGGTDD VVFGATGSGR
PADLPGVESM VGLFINTLPI RVALDANQSV REWLRGMQEQ QVELRQYEYT PLVDIQGWSE
MTRNTALFES IFIFENYPIG ESVKDEQHQL RLSDVETIEQ TNYPLTVVCG PGEELIVKIK
YEQNRFAPEQ IERVLQQMSQ LLQDMTAKPE QRLQDVSMIS ERERQQVLVD WNETSVAYPQ
QLCVHQAFEQ QVEKTPDAVA LVYKDVELTY AELNERANQL AHRLLAEGVK PDELVGICVE
RSPEMIVAFL GVMKAGAAYV PLDPAHPQER IAYMIEDSQA SVLLTQASLT DRLPASSRQV
ICLDSDELAN EPVTNAETSV GEHNLAYVIY TSGSTGLPKG VMIEHRSVIN LAYDLIRHFQ
IDATSRVLQF ISFSFDVSVS EIVMSLLAGA TLVIEDRESL LPGPELIRVL QEQRITTFAM
VSSVLAALPE ADLPDLRTII VGGEAPSREL VARYATGRQF INCYGPTETT VTATLKHCQD
DGKNPPIGRP IANTTVYVLD AHLQPVPIGV PGELYIGGKG VARGYWNRPE LTAERFIADP
FGQADERLYR TGDLVRYLEN GELEFLGRID DQVKIRGYRI ELGEIENALR QHPAVQNVVV
IARQEGAGDK RLAAYLVAAT GQQPDEAELV RYLKSTLPEY MVPAGYVWLE KIPLTVNGKV
DRRALPAPDY GHAETGKAYV APRKPIEEIV ANIWAQVLSV ERVGVYDDFF ELGGHSLLAT
QAVSRLKEAF GVNVPLRTLF EHPDVAGMSE KLAGLLEEQS GVTSIPLVPV PRDKQLPLSF
AQQRLWFLDR LMPDSALYNI PSAVRIQGQL NIRAWERSLQ TIIERHESLR TTFTDIGGEA
VQVIHEMMEW RLVEIDLRDL PDEEREAAVQ RLEKAEASQP FNLRTGPLLR ATLIQTGEED
FVFLLNMHHI VSDGWSMSIF MGELATIYEA LSKGDTPQLA EMPLQYADFA AWQRDWLQGE
VLEQQLAYWR EKLGAAEPML ALPTDRPRPA VQTHHGALYT TAFPLALTEK LHALSRQEGA
TLFMTLLAAF QTLLYRYSGQ DDIIVGSPVA GRNKQETESM IGFFINTLAM RTDMSGAPTF
RELLARVRDT ALEAYTHQDL PFEKLIDELE LERSLSYSPL FQVMFALQNF QMLTREFEGI
EIVPFESKNE AVMSKYDISL TMAETQNGLV ATFDYNTDLF DHSTIVRMVN HFHQLLEGIV
ARPDSSIQAL PLLATDEREQ LVSAWNNTAA AYTYEQTVHE LVAAMAEKMP EQLAVVSAEG
SLTYAQLDAK ANQLANYLQQ QGITPETLVG ICVERSSEMI VGQLGILKAG GAFVPMDPAY
PQERLAFMMA DTGMPFVLTQ ERLLETLPAG DAAFICLDAD WEVIAEESTQ APELAVTTDQ
LAYVIYTSGS TGTPKGVEIE HRALLNLIYW HQHAYTITPD DRASQIAGTA FDAAVWEIWP
YMTAGATLYL PQEEIRLIPE KLRDWLVAEG ITISFLPTPL AESMLSVDWP SHAALRYVLT
GGDKLHHYPA EHVPFTLVNQ YGPTENAVVA TAGIVAVQAG QVTPPSIGRP IDNVQVYILD
EQRQPVPIGV TGELYIAGSS LARGYYKRPD LTQERFVDNP FTANRGAKMY RTGDLVRYLP
DGQIEFIGRS DDQVSIRGFR VELGEIESVL YQHPAVKEAI VLAREDMPGV KRLAAYVVVA
EDDAEQADDL RGYLKEKLPE YMVPAAFVTL KALPLTPNGK VDRRALPVPE YTAADGEYVA
PETFVEKVLA QIWKEVLGVE EVGIHDNFFE LGGDSILSIQ IVARAGQSGI RLSPKLLFEN
QTIAELSHAV GDSVHICAEQ GLVTGEVPLL PIQHWFFEQK LADRNHWNQS VLLTVQPIDP
EILKQAFYHL LGHHDALRLR FYHQNGAWKQ AGAEWTDIIP FYVVELGDLP ANQQVEQIEK
LSGEAQASLH LADGPLLRAV YFDMGAGQEG RLLIVIHHLA VDGVSWRIIT EDLNKACNQL
LQGKQVQLPP KTSSYKYWAE KLVEYAASDS LTEEADYWLS RLDTEVAALP KDYEHGQNRE
LAARTVSVAL TQEETKVLLQ ELPAVYQTQI NDVLLTALAE AVFVWTGNQT TLVHLEGHGR
EDIFDDVDLS RTVGWFTSMY TILLDTRGTS SLTEALQTTK EQLRSIPHKG IGYGILRYLN
KETAEKFKSL PKAQISFNYL GQLDQAVRDT DSLFGFASEA RGDNFNRNSD RQHLLDFGCS
VVGGQLVVSV AFSKEIYRKE TIEALADYYI TALRQLLAHA KTDKAAAPAQ SAASNLSEFG
WDDEEIADLL DLIQDK
