ID   LGTB_NEIMA              Reviewed;         279 AA.
AC   P57033; A1IPY1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Lacto-N-neotetraose biosynthesis glycosyltransferase LgtB;
DE            EC=2.-.-.-;
GN   Name=lgtB; OrderedLocusNames=NMA0525;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: Adds the second galactose to the lacto-N-tetraose chain in
CC       lipooligosaccharide (LOS).
CC   -!- PATHWAY: Glycan metabolism; lacto-N-neotetraose biosynthesis.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipooligosaccharide
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 25 family.
CC       {ECO:0000305}.
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DR   EMBL; AL157959; CAM07802.1; -; Genomic_DNA.
DR   PIR; A81971; A81971.
DR   RefSeq; WP_002246454.1; NC_003116.1.
DR   AlphaFoldDB; P57033; -.
DR   CAZy; GT25; Glycosyltransferase Family 25.
DR   EnsemblBacteria; CAM07802; CAM07802; NMA0525.
DR   KEGG; nma:NMA0525; -.
DR   HOGENOM; CLU_071269_2_1_4; -.
DR   OMA; WRDSPAN; -.
DR   BioCyc; NMEN122587:NMA_RS02650-MON; -.
DR   BRENDA; 2.4.1.38; 17376.
DR   UniPathway; UPA00501; -.
DR   UniPathway; UPA00820; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd06532; Glyco_transf_25; 1.
DR   InterPro; IPR002654; Glyco_trans_25.
DR   Pfam; PF01755; Glyco_transf_25; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipopolysaccharide biosynthesis; Transferase.
FT   CHAIN           1..279
FT                   /note="Lacto-N-neotetraose biosynthesis glycosyltransferase
FT                   LgtB"
FT                   /id="PRO_0000216236"
SQ   SEQUENCE   279 AA;  31904 MW;  8703B56513A0D347 CRC64;
     MQNHVISLAS AAERRAHITD TFGVRGIPFQ FFDALMPSER LEQAMAELVP GLSAHPYLSG
     VEKACFMSHA VLWKQALDEG LPYIAVFEDD VLLGEGAEKF LAEDAWLQER FDPDSAFIVR
     LETMFMHVLT SPSGVADYCG RAFPLLESEH WGTAGYIISR KAMWFFLDRF AALPSEGLHP
     VDWMMFGNPD DRERMPVCQL NPALCAQELH YAKFHDQNSA LGSLIEHDRC LNSKQQRRDS
     PANTFKHRLI RALTKISRER EKRRQRREQL IGKIIVPFQ