ID   LGT_CERSP               Reviewed;         202 AA.
AC   O33551;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase {ECO:0000250};
DE            EC=2.5.1.145 {ECO:0000250};
DE   Flags: Fragment;
GN   Name=lgt; Synonyms=umpA;
OS   Cereibacter sphaeroides (Rhodobacter sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=1063;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WS8;
RX   PubMed=9426144; DOI=10.1046/j.1365-2958.1997.6502022.x;
RA   Hamblin P.A., Maguire B.A., Grishanin R.N., Armitage J.P.;
RT   "Evidence for two chemosensory pathways in Rhodobacter sphaeroides.";
RL   Mol. Microbiol. 26:1083-1096(1997).
CC   -!- FUNCTION: Catalyzes the transfer of the diacylglyceryl group from
CC       phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine
CC       of a prolipoprotein, the first step in the formation of mature
CC       lipoproteins. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-
CC         cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-
CC         cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate;
CC         Xref=Rhea:RHEA:56712, Rhea:RHEA-COMP:14679, Rhea:RHEA-COMP:14680,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:57685,
CC         ChEBI:CHEBI:64716, ChEBI:CHEBI:140658; EC=2.5.1.145;
CC         Evidence={ECO:0000250};
CC   -!- PATHWAY: Protein modification; lipoprotein biosynthesis (diacylglyceryl
CC       transfer).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Lgt family. {ECO:0000305}.
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DR   EMBL; AJ000977; CAA04426.1; -; Genomic_DNA.
DR   PIR; T45014; T45014.
DR   AlphaFoldDB; O33551; -.
DR   SMR; O33551; -.
DR   UniPathway; UPA00664; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0008961; F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042158; P:lipoprotein biosynthetic process; IEA:InterPro.
DR   InterPro; IPR001640; Lgt.
DR   PANTHER; PTHR30589; PTHR30589; 1.
DR   Pfam; PF01790; LGT; 1.
DR   TIGRFAMs; TIGR00544; lgt; 1.
DR   PROSITE; PS01311; LGT; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..>202
FT                   /note="Phosphatidylglycerol--prolipoprotein diacylglyceryl
FT                   transferase"
FT                   /id="PRO_0000172662"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   NON_TER         202
SQ   SEQUENCE   202 AA;  22300 MW;  A8AAD9C6F1617C11 CRC64;
     MSYIPFPDIS PELFSIELFG VTFALRWYAL AYIAGLLIGW RLVLRMIRAE RLWSFGPPMT
     EDQLERLLTW VILGVILGGR LGFVLFYQPA HYLAHPLDIL KVWEGGMSFH GGFLGVMTAL
     VAFCLKERIS ILPVADLLAA ATPPGLFLGR IANFINAELW GRPTTLPWGV AFPGEAAQSC
     PGIEGICARH PSQIYEAGLE GI