ID   LH3_ADEO7               Reviewed;         382 AA.
AC   Q83924;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 62.
DE   RecName: Full=Hexon-interlacing protein LH3;
OS   Ovine adenovirus D serotype 7 (isolate OAV287) (OAdV-7) (Ovine adenovirus
OS   7).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Atadenovirus.
OX   NCBI_TaxID=114430;
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8659111; DOI=10.1006/viro.1996.0299;
RA   Vrati S., Brookes D.E., Strike P., Khatri A., Boyle D.B., Both G.W.;
RT   "Unique genome arrangement of an ovine adenovirus: identification of new
RT   proteins and proteinase cleavage sites.";
RL   Virology 220:186-199(1996).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=16112161; DOI=10.1016/j.virol.2005.07.020;
RA   Gorman J.J., Wallis T.P., Whelan D.A., Shaw J., Both G.W.;
RT   "LH3, a 'homologue' of the mastadenoviral E1B 55-kDa protein is a
RT   structural protein of atadenoviruses.";
RL   Virology 342:159-166(2005).
RN   [3]
RP   FUNCTION, INTERACTION WITH HEXON PROTEIN, AND SUBUNIT.
RX   PubMed=18508893; DOI=10.1128/jvi.00764-08;
RA   Pantelic R.S., Lockett L.J., Rothnagel R., Hankamer B., Both G.W.;
RT   "Cryoelectron microscopy map of Atadenovirus reveals cross-genus structural
RT   differences from human adenovirus.";
RL   J. Virol. 82:7346-7356(2008).
CC   -!- FUNCTION: Structural component of the virion that presumably stabilizes
CC       the groups of hexons but is dispensable for assembly.
CC       {ECO:0000269|PubMed:18508893}.
CC   -!- SUBUNIT: Homotrimer. Interacts with hexon protein; this interaction
CC       tethers the hexons together. {ECO:0000269|PubMed:18508893}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:16112161}.
CC   -!- SIMILARITY: Belongs to the atadenoviridae LH3 protein family.
CC       {ECO:0000305}.
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DR   EMBL; U40839; AAB19239.1; -; Genomic_DNA.
DR   RefSeq; NP_659513.1; NC_004037.2.
DR   SMR; Q83924; -.
DR   GeneID; 949198; -.
DR   KEGG; vg:949198; -.
DR   Proteomes; UP000008089; Genome.
DR   InterPro; IPR002612; Adeno_E1B_55kDa.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   Pfam; PF01696; Adeno_E1B_55K; 1.
DR   SUPFAM; SSF51126; SSF51126; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Virion.
FT   CHAIN           1..382
FT                   /note="Hexon-interlacing protein LH3"
FT                   /id="PRO_0000425919"
SQ   SEQUENCE   382 AA;  42839 MW;  3D48AFF06340D285 CRC64;
     MTSAEFSVEF PYVSKPIVPW PASASSNNSS SQNIDFPVLK PDQDPIAFFQ TNNTAYLQPG
     ATYYWKCIEL SKPIHIYGQG ATVQLVGPGP VFVFNSESVI PEDFYVVFEN INFIEDEFPI
     RSGQLSLGLT THSAVWFINV WKTSIVNCNF KNFRGAALWY SDNRNFWNAR KWNQQHLVSN
     CRFNGCRIGI SNTGSSEYSI ASQNQFYDCQ ICFNVTGGNW SRNNNVIVNC RCAYLHVGDN
     MWYEGHSENN NPAKGTFCNN IINHADNGGN VWPTQFKLTD GSTIQLASFY FDDNQEIPPC
     YSGNFHWFGD VNIVNFSTTK IDKWCITGCN FYGNTHAAND AGQVQVAEAV KDKVFIIGCS
     GNNVTMKNIV EGNMTPKIGT IK