LHP1_ORYSJ
ID LHP1_ORYSJ Reviewed; 415 AA.
AC Q339W7; B7F9Z6; Q0IYF0; Q8S793; Q94HR8;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Probable chromo domain-containing protein LHP1;
DE AltName: Full=Protein LIKE HETEROCHROMATIN PROTEIN 1;
GN Name=LHP1; OrderedLocusNames=Os10g0324900, LOC_Os10g17770;
GN ORFNames=OSJNBa0065C16.1, OSJNBa0093I09.2;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12791992; DOI=10.1126/science.1083523;
RA Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RG The rice full-length cDNA consortium;
RT "Oryza sativa full length cDNA.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Structural component of heterochromatin involved in gene
CC repression. Recognizes and binds histone H3 tails methylated at 'Lys-
CC 9', leading to epigenetic repression (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The chromo domain specifically binds to dimethylated H3 'Lys-9'
CC while the chromo shadow domain is required for dimerization.
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK92567.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF26265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC074354; AAK92567.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC090486; AAM08791.1; -; Genomic_DNA.
DR EMBL; DP000086; ABB47160.1; -; Genomic_DNA.
DR EMBL; AP008216; BAF26265.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014966; BAT10326.1; -; Genomic_DNA.
DR EMBL; AK243085; BAH01444.1; -; mRNA.
DR RefSeq; XP_015614736.1; XM_015759250.1.
DR AlphaFoldDB; Q339W7; -.
DR SMR; Q339W7; -.
DR STRING; 4530.OS10T0324900-01; -.
DR PaxDb; Q339W7; -.
DR PRIDE; Q339W7; -.
DR EnsemblPlants; Os10t0324900-01; Os10t0324900-01; Os10g0324900.
DR GeneID; 9268323; -.
DR Gramene; Os10t0324900-01; Os10t0324900-01; Os10g0324900.
DR KEGG; osa:9268323; -.
DR eggNOG; KOG1911; Eukaryota.
DR HOGENOM; CLU_035097_0_0_1; -.
DR InParanoid; Q339W7; -.
DR OMA; YYEQCLR; -.
DR OrthoDB; 1173381at2759; -.
DR Proteomes; UP000000763; Chromosome 10.
DR Proteomes; UP000059680; Chromosome 10.
DR Genevisible; Q339W7; OS.
DR GO; GO:0000792; C:heterochromatin; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031507; P:heterochromatin assembly; IEA:InterPro.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR017984; Chromo_dom_subgr.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR008251; Chromo_shadow_dom.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR044251; LHP1-like.
DR PANTHER; PTHR47240; PTHR47240; 1.
DR Pfam; PF00385; Chromo; 1.
DR PRINTS; PR00504; CHROMODOMAIN.
DR SMART; SM00298; CHROMO; 1.
DR SMART; SM00300; ChSh; 1.
DR SUPFAM; SSF54160; SSF54160; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 2: Evidence at transcript level;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..415
FT /note="Probable chromo domain-containing protein LHP1"
FT /id="PRO_0000247866"
FT DOMAIN 107..166
FT /note="Chromo 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00053"
FT DOMAIN 348..412
FT /note="Chromo 2; shadow subtype"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00053"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..77
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 415 AA; 45675 MW; C4BB0761A9B396BB CRC64;
MARGKNHPDG EEEEAPAAAG EEEAPVEMDE EGEMEEEEEE EQGEGEGEER DEGEEEEEWE
DAEEVEGGEE SEQAAAEEED SPLVVVEAEA AAPVVDGSPP KLAEGYYEIE DIRRRRLRKG
KLQYLVKWRG WPESANTWEP LENLSACSDI IDAFEMRLQS PRPGRKRKRK ITTTPVAGSN
PSHGKRGRPR LDAKSHTRAP APEPKQLPCR TSCRRATNCS SKTVAGLDAS GSVVRNQLAQ
NIVQEGSSSV ISRTPCQELP LSIRLTDQQN EHHLVNGSSN SENLVKVPPS QGGQVTGAKK
RKSGNVRRFE QNKPTQGQGE CGALVVAEDV GSTEGETGDK KKTEGCPNRV HITKIIKPVR
FAAAVNNDVQ QVSITFKALR SDGQEVMVDD KELKANNPLL LISYYEQCLR YNPTS
