ID   LHP1_SOLLC              Reviewed;         399 AA.
AC   Q944N1;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Chromo domain protein LHP1;
DE   AltName: Full=Protein LIKE HETEROCHROMATIN PROTEIN 1;
DE   AltName: Full=Sl LHP1;
GN   Name=LHP1; Synonyms=HP1-L;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF 114-TRP--TRP-117, INTERACTION
RP   WITH H3, AND SUBCELLULAR LOCATION.
RX   PubMed=16361394; DOI=10.1105/tpc.105.036855;
RA   Zemach A., Li Y., Ben-Meir H., Oliva M., Mosquna A., Kiss V., Avivi Y.,
RA   Ohad N., Grafi G.;
RT   "Different domains control the localization and mobility of LIKE
RT   HETEROCHROMATIN PROTEIN1 in Arabidopsis nuclei.";
RL   Plant Cell 18:133-145(2006).
CC   -!- FUNCTION: Structural component of heterochromatin involved in gene
CC       repression. Recognizes and binds histone H3 tails methylated at 'Lys-
CC       9', leading to epigenetic repression.
CC   -!- SUBUNIT: Homodimer. Interacts with H3. {ECO:0000269|PubMed:16361394}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16361394}.
CC       Note=Punctuated distribution and in heterochromatic chromocenters.
CC   -!- DOMAIN: The chromo domain specifically binds to dimethylated H3 'Lys-9'
CC       while the chromo shadow domain is required for dimerization.
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Heterologous expression in Arabidopsis shows an
CC       additional localization at specific nucleolar compartments and a cell-
CC       type dependent subnuclear localization.
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DR   EMBL; AF428244; AAL25116.2; -; mRNA.
DR   AlphaFoldDB; Q944N1; -.
DR   SMR; Q944N1; -.
DR   STRING; 4081.Solyc01g081500.2.1; -.
DR   PaxDb; Q944N1; -.
DR   PRIDE; Q944N1; -.
DR   eggNOG; KOG1911; Eukaryota.
DR   InParanoid; Q944N1; -.
DR   Proteomes; UP000004994; Unplaced.
DR   ExpressionAtlas; Q944N1; baseline and differential.
DR   GO; GO:0000792; C:heterochromatin; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031507; P:heterochromatin assembly; IEA:InterPro.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR023780; Chromo_domain.
DR   InterPro; IPR008251; Chromo_shadow_dom.
DR   InterPro; IPR023779; Chromodomain_CS.
DR   InterPro; IPR044251; LHP1-like.
DR   PANTHER; PTHR47240; PTHR47240; 1.
DR   Pfam; PF00385; Chromo; 1.
DR   SMART; SM00298; CHROMO; 1.
DR   SMART; SM00300; ChSh; 1.
DR   SUPFAM; SSF54160; SSF54160; 1.
DR   PROSITE; PS00598; CHROMO_1; 1.
DR   PROSITE; PS50013; CHROMO_2; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..399
FT                   /note="Chromo domain protein LHP1"
FT                   /id="PRO_0000247865"
FT   DOMAIN          93..152
FT                   /note="Chromo 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00053"
FT   DOMAIN          332..396
FT                   /note="Chromo 2; shadow subtype"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00053"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         114..117
FT                   /note="WRGW->GRGG: Loss of interaction with 'K-9' of H3 and
FT                   loss of chromocenter localization and punctuated
FT                   distribution inside the nucleus."
FT                   /evidence="ECO:0000269|PubMed:16361394"
SQ   SEQUENCE   399 AA;  44098 MW;  F8C3980FF4DB998B CRC64;
     MKEGKRKSSR LQSEAAGAGS SRKLDLDGVA AERQERNGYP EDAGSKCEEE PVAGEGEGEG
     EEKDEAPEVV RVEKGDGDGV AKKVKPKLAE GFYEIETVRR RRTVKGKVYY LIKWRGWPES
     ANTWEPETNL SSCTDIIDAY EESLKSGKLR RRKRKFGATQ THPMIKQQRR FSAPVATYNG
     PAVKVRIIEE PTPSPPLNVL KATDLVDSNG SELNSKVDEV VNGNGLRLRE QNELNLKLSE
     LKGATSTNGN PVDISGNGLT NGFPKVNGAE FYQSDRCTGA KKRKSGCVRR FKRETTSAVK
     DDTQDALAGG PLATFMQDGS HNHVMVADDS KDGYTITQLV NPVSYKASFS NDMLDVSVTF
     VAKRADGNLV LVDNKFLKMN NPLLLINFYE ENMRYHPTE