LHPL1_HUMAN
ID LHPL1_HUMAN Reviewed; 220 AA.
AC Q86WI0; A8K1N1; Q496M9; Q496N0; Q6UXU2;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=LHFPL tetraspan subfamily member 1 protein {ECO:0000312|HGNC:HGNC:6587};
DE AltName: Full=Lipoma HMGIC fusion partner-like 1 protein {ECO:0000312|HGNC:HGNC:6587};
DE Flags: Precursor;
GN Name=LHFPL1 {ECO:0000312|HGNC:HGNC:6587}; ORFNames=UNQ5824/PRO19643;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=15620218; DOI=10.1080/10425170412331279620;
RA Huang C., Guo J., Liu S., Shan Y., Wu S., Cai Y., Yu L.;
RT "Isolation, tissue distribution and prokaryotic expression of a novel human
RT X-linked gene LHFPL1.";
RL DNA Seq. 15:299-302(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q86WI0; P24593: IGFBP5; NbExp=3; IntAct=EBI-18268016, EBI-720480;
CC Q86WI0; O43561-2: LAT; NbExp=3; IntAct=EBI-18268016, EBI-8070286;
CC Q86WI0; Q04941: PLP2; NbExp=3; IntAct=EBI-18268016, EBI-608347;
CC Q86WI0; O75396: SEC22B; NbExp=3; IntAct=EBI-18268016, EBI-1058865;
CC Q86WI0; Q9UPZ6: THSD7A; NbExp=3; IntAct=EBI-18268016, EBI-310962;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q86WI0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86WI0-2; Sequence=VSP_019617;
CC Name=3;
CC IsoId=Q86WI0-3; Sequence=VSP_019616;
CC -!- TISSUE SPECIFICITY: Widely expressed. Expressed at high levels in lung,
CC thymus, skeletal muscle, colon and ovary.
CC {ECO:0000269|PubMed:15620218}.
CC -!- SIMILARITY: Belongs to the LHFP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ88575.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY217350; AAO60107.1; -; mRNA.
DR EMBL; AY358208; AAQ88575.1; ALT_INIT; mRNA.
DR EMBL; AK289946; BAF82635.1; -; mRNA.
DR EMBL; BC100785; AAI00786.1; -; mRNA.
DR EMBL; BC100786; AAI00787.1; -; mRNA.
DR EMBL; BC100787; AAI00788.1; -; mRNA.
DR CCDS; CCDS14562.1; -. [Q86WI0-1]
DR RefSeq; NP_835469.1; NM_178175.3. [Q86WI0-1]
DR RefSeq; XP_011529245.1; XM_011530943.2.
DR RefSeq; XP_011529246.1; XM_011530944.2. [Q86WI0-1]
DR RefSeq; XP_011529248.1; XM_011530946.2. [Q86WI0-2]
DR RefSeq; XP_016884974.1; XM_017029485.1.
DR AlphaFoldDB; Q86WI0; -.
DR SMR; Q86WI0; -.
DR BioGRID; 131083; 16.
DR IntAct; Q86WI0; 5.
DR STRING; 9606.ENSP00000361036; -.
DR GlyGen; Q86WI0; 1 site.
DR BioMuta; LHFPL1; -.
DR DMDM; 74714099; -.
DR PaxDb; Q86WI0; -.
DR PeptideAtlas; Q86WI0; -.
DR PRIDE; Q86WI0; -.
DR Antibodypedia; 559; 94 antibodies from 17 providers.
DR DNASU; 340596; -.
DR Ensembl; ENST00000371968.8; ENSP00000361036.3; ENSG00000182508.14. [Q86WI0-1]
DR GeneID; 340596; -.
DR KEGG; hsa:340596; -.
DR MANE-Select; ENST00000371968.8; ENSP00000361036.3; NM_178175.4; NP_835469.1.
DR UCSC; uc004epq.4; human. [Q86WI0-1]
DR CTD; 340596; -.
DR GeneCards; LHFPL1; -.
DR HGNC; HGNC:6587; LHFPL1.
DR HPA; ENSG00000182508; Group enriched (brain, salivary gland).
DR MIM; 300566; gene.
DR neXtProt; NX_Q86WI0; -.
DR OpenTargets; ENSG00000182508; -.
DR PharmGKB; PA30359; -.
DR VEuPathDB; HostDB:ENSG00000182508; -.
DR eggNOG; KOG4026; Eukaryota.
DR GeneTree; ENSGT00990000203589; -.
DR HOGENOM; CLU_084868_2_0_1; -.
DR InParanoid; Q86WI0; -.
DR OMA; VMQTCGN; -.
DR OrthoDB; 1383327at2759; -.
DR PhylomeDB; Q86WI0; -.
DR TreeFam; TF321143; -.
DR PathwayCommons; Q86WI0; -.
DR SignaLink; Q86WI0; -.
DR BioGRID-ORCS; 340596; 11 hits in 691 CRISPR screens.
DR ChiTaRS; LHFPL1; human.
DR GeneWiki; LHFPL1; -.
DR GenomeRNAi; 340596; -.
DR Pharos; Q86WI0; Tdark.
DR PRO; PR:Q86WI0; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q86WI0; protein.
DR Bgee; ENSG00000182508; Expressed in nucleus accumbens and 72 other tissues.
DR Genevisible; Q86WI0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR019372; LHFPL.
DR PANTHER; PTHR12489; PTHR12489; 1.
DR Pfam; PF10242; L_HMGIC_fpl; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..220
FT /note="LHFPL tetraspan subfamily member 1 protein"
FT /id="PRO_0000244760"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..179
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019616"
FT VAR_SEQ 129..161
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019617"
SQ SEQUENCE 220 AA; 23777 MW; 6BD3E610319E0CF2 CRC64;
MRSSLTMVGT LWAFLSLVTA VTSSTSYFLP YWLFGSQMGK PVSFSTFRRC NYPVRGEGHS
LIMVEECGRY ASFNAIPSLA WQMCTVVTGA GCALLLLVAL AAVLGCCMEE LISRMMGRCM
GAAQFVGGLL ISSGCALYPL GWNSPEIMQT CGNVSNQFQL GTCRLGWAYY CAGGGAAAAM
LICTWLSCFA GRNPKPVILV ESIMRNTNSY AMELDHCLKP
