LHPL1_MOUSE
ID LHPL1_MOUSE Reviewed; 220 AA.
AC Q80SV1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=LHFPL tetraspan subfamily member 1 protein {ECO:0000250|UniProtKB:Q86WI0};
DE AltName: Full=Lipoma HMGIC fusion partner-like 1 protein {ECO:0000312|MGI:MGI:1891214};
DE Flags: Precursor;
GN Name=Lhfpl1 {ECO:0000312|MGI:MGI:1891214}; Synonyms=Lhfpl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang C.Q., Wu S.L., Liu S.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=26964900; DOI=10.1038/srep23037;
RA Zhao F., Zhou J., Li R., Dudley E.A., Ye X.;
RT "Novel function of LHFPL2 in female and male distal reproductive tract
RT development.";
RL Sci. Rep. 6:23037-23037(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed (PubMed:26964900). Strongly
CC expressed in vagina and ovary. Weakly expressed in spleen, kidney,
CC thymus, testis, brain, lung, intestine and uterus (PubMed:26964900).
CC {ECO:0000269|PubMed:26964900}.
CC -!- SIMILARITY: Belongs to the LHFP family. {ECO:0000305}.
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DR EMBL; AY253666; AAP14355.1; -; mRNA.
DR EMBL; AK142526; BAE25096.1; -; mRNA.
DR EMBL; BC051434; AAH51434.1; -; mRNA.
DR CCDS; CCDS30458.1; -.
DR RefSeq; NP_848135.1; NM_178358.3.
DR RefSeq; XP_006528863.1; XM_006528800.2.
DR RefSeq; XP_006528864.1; XM_006528801.3.
DR AlphaFoldDB; Q80SV1; -.
DR SMR; Q80SV1; -.
DR STRING; 10090.ENSMUSP00000044054; -.
DR GlyGen; Q80SV1; 1 site.
DR PaxDb; Q80SV1; -.
DR PRIDE; Q80SV1; -.
DR Antibodypedia; 559; 94 antibodies from 17 providers.
DR Ensembl; ENSMUST00000040084; ENSMUSP00000044054; ENSMUSG00000041700.
DR GeneID; 237091; -.
DR KEGG; mmu:237091; -.
DR UCSC; uc009umz.1; mouse.
DR CTD; 340596; -.
DR MGI; MGI:1891214; Lhfpl1.
DR VEuPathDB; HostDB:ENSMUSG00000041700; -.
DR eggNOG; KOG4026; Eukaryota.
DR GeneTree; ENSGT00990000203589; -.
DR HOGENOM; CLU_084868_2_0_1; -.
DR InParanoid; Q80SV1; -.
DR OMA; VMQTCGN; -.
DR OrthoDB; 1383327at2759; -.
DR PhylomeDB; Q80SV1; -.
DR TreeFam; TF321143; -.
DR BioGRID-ORCS; 237091; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Lhfpl1; mouse.
DR PRO; PR:Q80SV1; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q80SV1; protein.
DR Bgee; ENSMUSG00000041700; Expressed in animal zygote and 35 other tissues.
DR ExpressionAtlas; Q80SV1; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR019372; LHFPL.
DR PANTHER; PTHR12489; PTHR12489; 1.
DR Pfam; PF10242; L_HMGIC_fpl; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..220
FT /note="LHFPL tetraspan subfamily member 1 protein"
FT /id="PRO_0000244761"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 220 AA; 23787 MW; ACFFF29D253E6C9B CRC64;
MRNSLTMVGT FWAFLSLVTA VASSTSYFLP YWLFGSQLGK PVSFSTFRRC NYPVRGDGHN
LIMVEECGRY ASFTAIPSLA WQMCTVVTGA GCALLLLVAL AAVLGCCMEE LISRMMGRCM
GAAQFVGGLL ISAGCALYPL GWNSPEVMQT CGNVSNQFQL GTCRLGWAYY CAGGGAAAAM
LICTWLSCFA GRNPKPVMLV ENIMRNTNSY ALELDHCLKP
