ID   LHPL2_DANRE             Reviewed;         225 AA.
AC   Q6P0C6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=LHFPL tetraspan subfamily member 2a protein {ECO:0000250|UniProtKB:Q6ZUX7};
GN   Name=lhfpl2a {ECO:0000250|UniProtKB:Q6ZUX7}; ORFNames=zgc:77456;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in fertility. Involved in distal reproductive
CC       tract development. {ECO:0000250|UniProtKB:Q8BGA2}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LHFP family. {ECO:0000305}.
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DR   EMBL; BC065671; AAH65671.1; -; mRNA.
DR   RefSeq; NP_991226.1; NM_205663.1.
DR   AlphaFoldDB; Q6P0C6; -.
DR   STRING; 7955.ENSDARP00000126208; -.
DR   PaxDb; Q6P0C6; -.
DR   Ensembl; ENSDART00000150913; ENSDARP00000126075; ENSDARG00000009653.
DR   Ensembl; ENSDART00000151613; ENSDARP00000126208; ENSDARG00000009653.
DR   GeneID; 402962; -.
DR   KEGG; dre:402962; -.
DR   CTD; 402962; -.
DR   ZFIN; ZDB-GENE-040426-1839; lhfpl2a.
DR   eggNOG; KOG4026; Eukaryota.
DR   GeneTree; ENSGT00990000203589; -.
DR   InParanoid; Q6P0C6; -.
DR   OrthoDB; 1431349at2759; -.
DR   PhylomeDB; Q6P0C6; -.
DR   Reactome; R-DRE-114608; Platelet degranulation.
DR   PRO; PR:Q6P0C6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000009653; Expressed in intestine and 28 other tissues.
DR   ExpressionAtlas; Q6P0C6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0046545; P:development of primary female sexual characteristics; ISS:UniProtKB.
DR   GO; GO:0046546; P:development of primary male sexual characteristics; ISS:UniProtKB.
DR   GO; GO:1905516; P:positive regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   InterPro; IPR019372; LHFPL.
DR   PANTHER; PTHR12489; PTHR12489; 1.
DR   Pfam; PF10242; L_HMGIC_fpl; 1.
PE   2: Evidence at transcript level;
KW   Fertilization; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..225
FT                   /note="LHFPL tetraspan subfamily member 2a protein"
FT                   /id="PRO_0000244765"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   225 AA;  24163 MW;  0A6A13B564120783 CRC64;
     MCHVIVTCRS MLWTLLSIVA AFSELIAFLS TDWLVGFPRA PDAGFSPLGA TAAGEAYRPT
     LGIYGRCIRV PHYRRGVLCG PYAVHFGEIA SGFWQATAIF LAAGILLLCA VAFISIFTMC
     FQSIMKKSIF NVCGLLQAIA GLFLIVGLVL YPAGWGSQKV QLYCGPDSSP YRLGLCSAGW
     AFYTALAGTV LCFLCAVFSA QAEIATSSDK VQEEIQEGKS LICLL