LHPL3_HUMAN
ID LHPL3_HUMAN Reviewed; 236 AA.
AC Q86UP9; A1L383; A4D0Q5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 3.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=LHFPL tetraspan subfamily member 3 protein {ECO:0000312|HGNC:HGNC:6589};
DE AltName: Full=Lipoma HMGIC fusion partner-like 3 protein {ECO:0000312|HGNC:HGNC:6589};
GN Name=LHFPL3 {ECO:0000312|HGNC:HGNC:6589};
GN Synonyms=LHFPL4 {ECO:0000312|HGNC:HGNC:6589};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Huang C.Q., Wu S.L., Liu S., Shan Y.X., Xiao P.J.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q86UP9; P57054: PIGP; NbExp=3; IntAct=EBI-12925734, EBI-17630288;
CC Q86UP9; Q9Y225-2: RNF24; NbExp=3; IntAct=EBI-12925734, EBI-13044680;
CC Q86UP9; O43557: TNFSF14; NbExp=3; IntAct=EBI-12925734, EBI-524131;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LHFP family. {ECO:0000305}.
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DR EMBL; AY260763; AAP14954.1; -; mRNA.
DR EMBL; AK299759; BAG61648.1; -; mRNA.
DR EMBL; CH236947; EAL24407.1; -; Genomic_DNA.
DR EMBL; BC129937; AAI29938.1; -; mRNA.
DR RefSeq; NP_945351.1; NM_199000.2.
DR AlphaFoldDB; Q86UP9; -.
DR SMR; Q86UP9; -.
DR BioGRID; 131989; 3.
DR IntAct; Q86UP9; 3.
DR STRING; 9606.ENSP00000393128; -.
DR iPTMnet; Q86UP9; -.
DR PhosphoSitePlus; Q86UP9; -.
DR BioMuta; LHFPL3; -.
DR DMDM; 109892510; -.
DR MassIVE; Q86UP9; -.
DR PaxDb; Q86UP9; -.
DR PeptideAtlas; Q86UP9; -.
DR PRIDE; Q86UP9; -.
DR ProteomicsDB; 69857; -.
DR Antibodypedia; 55169; 58 antibodies from 15 providers.
DR DNASU; 375612; -.
DR Ensembl; ENST00000424859.7; ENSP00000393128.2; ENSG00000187416.13.
DR GeneID; 375612; -.
DR KEGG; hsa:375612; -.
DR MANE-Select; ENST00000424859.7; ENSP00000393128.2; NM_199000.3; NP_945351.1.
DR UCSC; uc064gsi.1; human.
DR CTD; 375612; -.
DR DisGeNET; 375612; -.
DR GeneCards; LHFPL3; -.
DR HGNC; HGNC:6589; LHFPL3.
DR HPA; ENSG00000187416; Group enriched (brain, retina).
DR MIM; 609719; gene.
DR neXtProt; NX_Q86UP9; -.
DR OpenTargets; ENSG00000187416; -.
DR PharmGKB; PA30361; -.
DR VEuPathDB; HostDB:ENSG00000187416; -.
DR eggNOG; KOG4026; Eukaryota.
DR GeneTree; ENSGT00990000203541; -.
DR InParanoid; Q86UP9; -.
DR OrthoDB; 1219117at2759; -.
DR PathwayCommons; Q86UP9; -.
DR SignaLink; Q86UP9; -.
DR BioGRID-ORCS; 375612; 11 hits in 308 CRISPR screens.
DR ChiTaRS; LHFPL3; human.
DR GenomeRNAi; 375612; -.
DR Pharos; Q86UP9; Tbio.
DR PRO; PR:Q86UP9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q86UP9; protein.
DR Bgee; ENSG00000187416; Expressed in lateral nuclear group of thalamus and 91 other tissues.
DR ExpressionAtlas; Q86UP9; baseline and differential.
DR Genevisible; Q86UP9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; IBA:GO_Central.
DR InterPro; IPR019372; LHFPL.
DR PANTHER; PTHR12489; PTHR12489; 1.
DR Pfam; PF10242; L_HMGIC_fpl; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..236
FT /note="LHFPL tetraspan subfamily member 3 protein"
FT /id="PRO_0000244766"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 18
FT /note="A -> T (in Ref. 4; AAI29938)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 236 AA; 25769 MW; 6066467C92D6FFF5 CRC64;
MPGAAAAAAA AAAAMLPAQE AAKLYHTNYV RNSRAIGVLW AIFTICFAIV NVVCFIQPYW
IGDGVDTPQA GYFGLFHYCI GNGFSRELTC RGSFTDFSTL PSGAFKAASF FIGLSMMLII
ACIICFTLFF FCNTATVYKI CAWMQLTSAA CLVLGCMIFP DGWDSDEVKR MCGEKTDKYT
LGACSVRWAY ILAIIGILDA LILSFLAFVL GNRQDSLMAE ELKAENKVLL SQYSLE
