LHPL3_MOUSE
ID LHPL3_MOUSE Reviewed; 222 AA.
AC Q9CTN8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=LHFPL tetraspan subfamily member 3 protein {ECO:0000312|MGI:MGI:1925076};
DE AltName: Full=Lipoma HMGIC fusion partner-like 3 protein {ECO:0000250|UniProtKB:Q86UP9};
GN Name=Lhfpl3 {ECO:0000312|MGI:MGI:1925076};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-222.
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=26964900; DOI=10.1038/srep23037;
RA Zhao F., Zhou J., Li R., Dudley E.A., Ye X.;
RT "Novel function of LHFPL2 in female and male distal reproductive tract
RT development.";
RL Sci. Rep. 6:23037-23037(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Brain-specific. {ECO:0000269|PubMed:26964900}.
CC -!- SIMILARITY: Belongs to the LHFP family. {ECO:0000305}.
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DR EMBL; AK020916; BAB32253.1; -; mRNA.
DR RefSeq; NP_084266.1; NM_029990.1.
DR AlphaFoldDB; Q9CTN8; -.
DR SMR; Q9CTN8; -.
DR iPTMnet; Q9CTN8; -.
DR PhosphoSitePlus; Q9CTN8; -.
DR SwissPalm; Q9CTN8; -.
DR EPD; Q9CTN8; -.
DR PRIDE; Q9CTN8; -.
DR ProteomicsDB; 265068; -.
DR GeneID; 269629; -.
DR KEGG; mmu:269629; -.
DR UCSC; uc008wpv.2; mouse.
DR CTD; 375612; -.
DR MGI; MGI:1925076; Lhfpl3.
DR InParanoid; Q9CTN8; -.
DR OrthoDB; 1219117at2759; -.
DR BioGRID-ORCS; 269629; 1 hit in 63 CRISPR screens.
DR ChiTaRS; Lhfpl3; mouse.
DR PRO; PR:Q9CTN8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9CTN8; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; IBA:GO_Central.
DR InterPro; IPR019372; LHFPL.
DR PANTHER; PTHR12489; PTHR12489; 1.
DR Pfam; PF10242; L_HMGIC_fpl; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..222
FT /note="LHFPL tetraspan subfamily member 3 protein"
FT /id="PRO_0000244767"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 222 AA; 24686 MW; 1F8BEECF56457B39 CRC64;
MLPAQEAAKL YHTNYVRNSR AIGVLWAIFT ICFAIINVVC FIQPYWIGDG VDTPQAGYFG
LFHYCIGNGF SRELTCRGSF TDFSTLPSGA FKAASFFIGL SMMLIIACIV CFTLFFFCNT
ATVYKICAWM QLTFAACLVL GCMIFPDGWD SDEAKRMCGE KTDKYTLGAC SVRWAYILAI
IGILDALILS FLAVVLGNRQ DSLMAEELKA ENKVLLSQYS LE
