LHPL5_CHICK
ID LHPL5_CHICK Reviewed; 221 AA.
AC Q7ZZL8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=LHFPL tetraspan subfamily member 5 protein {ECO:0000250|UniProtKB:Q8TAF8};
DE AltName: Full=Lipoma HMGIC fusion partner-like 5 protein {ECO:0000250|UniProtKB:Q8TAF8};
DE AltName: Full=Peripheral myelin protein 22a;
GN Name=LHFPL5 {ECO:0000250|UniProtKB:Q8TAF8};
GN Synonyms=PMP22A, TMHS {ECO:0000250|UniProtKB:Q4KL25};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang C.Q., Wu S.L., Liu S.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q4KL25};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the LHFP family. {ECO:0000305}.
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DR EMBL; AY265159; AAP21810.1; -; mRNA.
DR RefSeq; NP_989729.1; NM_204398.1.
DR RefSeq; XP_015154166.1; XM_015298680.1.
DR AlphaFoldDB; Q7ZZL8; -.
DR SMR; Q7ZZL8; -.
DR STRING; 9031.ENSGALP00000001317; -.
DR PaxDb; Q7ZZL8; -.
DR Ensembl; ENSGALT00000050484; ENSGALP00000053562; ENSGALG00000039170.
DR Ensembl; ENSGALT00000055378; ENSGALP00000045291; ENSGALG00000039170.
DR GeneID; 378916; -.
DR KEGG; gga:378916; -.
DR CTD; 222662; -.
DR VEuPathDB; HostDB:geneid_378916; -.
DR eggNOG; KOG4026; Eukaryota.
DR GeneTree; ENSGT00990000203541; -.
DR HOGENOM; CLU_084868_1_2_1; -.
DR InParanoid; Q7ZZL8; -.
DR OMA; RAMGVMW; -.
DR OrthoDB; 1219117at2759; -.
DR PhylomeDB; Q7ZZL8; -.
DR PRO; PR:Q7ZZL8; -.
DR Proteomes; UP000000539; Chromosome 26.
DR Bgee; ENSGALG00000039170; Expressed in brain and 13 other tissues.
DR ExpressionAtlas; Q7ZZL8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0050974; P:detection of mechanical stimulus involved in sensory perception; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; IBA:GO_Central.
DR InterPro; IPR019372; LHFPL.
DR PANTHER; PTHR12489; PTHR12489; 1.
DR Pfam; PF10242; L_HMGIC_fpl; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..221
FT /note="LHFPL tetraspan subfamily member 5 protein"
FT /id="PRO_0000285925"
FT TOPO_DOM 1..24
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..221
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 221 AA; 24420 MW; 5CB7D15B26DCCA83 CRC64;
MPKLLPAQEA ARIYHTNYVR NARAMGVLWA LFTLCFSILM VVTFIQPYWI GDSIDTPQAG
YFGLFSYCIG NALTGELICK GSPLDFGTIP SSAFKTAMFF VGISTFLIIG SILCFSLFFF
CNAATVYKVC AWMQLAAATG LMIGCLIYPD GWDSSEVKRM CGDKTDKYTL GACTVRWAYI
LCIIGILDAL ILSFLAFVLG NRQDNLLPSD FKVESKEEGN E
