ID   LHPL5_RAT               Reviewed;         219 AA.
AC   Q5PPI7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=LHFPL tetraspan subfamily member 5 protein {ECO:0000312|RGD:1359370};
DE   AltName: Full=Lipoma HMGIC fusion partner-like 5 protein {ECO:0000250|UniProtKB:Q8TAF8};
DE   AltName: Full=Tetraspan membrane protein of hair cell stereocilia {ECO:0000250|UniProtKB:Q4KL25};
GN   Name=Lhfpl5 {ECO:0000312|RGD:1359370};
GN   Synonyms=Tmhs {ECO:0000250|UniProtKB:Q4KL25};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: In the inner ear, may be a component of the hair cell's
CC       mechanotransduction machinery that functionally couples PCDH15 to the
CC       transduction channel. Regulates transducer channel conductance and is
CC       required for fast channel adaptation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Found in a complex with TMIE and PCDH15. Interacts with
CC       PCDH15; this interaction is required for efficient localization to hair
CC       bundles. Interacts with TOMT. {ECO:0000250|UniProtKB:Q4KL25}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q4KL25};
CC       Multi-pass membrane protein {ECO:0000250}. Note=Efficient localization
CC       to the plasma membrane requires the presence of PCDH15.
CC       {ECO:0000250|UniProtKB:Q4KL25}.
CC   -!- SIMILARITY: Belongs to the LHFP family. {ECO:0000305}.
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DR   EMBL; BC087673; AAH87673.1; -; mRNA.
DR   RefSeq; NP_001013928.1; NM_001013906.1.
DR   AlphaFoldDB; Q5PPI7; -.
DR   SMR; Q5PPI7; -.
DR   STRING; 10116.ENSRNOP00000030852; -.
DR   PaxDb; Q5PPI7; -.
DR   Ensembl; ENSRNOT00000036999; ENSRNOP00000030852; ENSRNOG00000022283.
DR   GeneID; 294303; -.
DR   KEGG; rno:294303; -.
DR   UCSC; RGD:1359370; rat.
DR   CTD; 222662; -.
DR   RGD; 1359370; Lhfpl5.
DR   eggNOG; KOG4026; Eukaryota.
DR   GeneTree; ENSGT00990000203541; -.
DR   HOGENOM; CLU_084868_1_2_1; -.
DR   InParanoid; Q5PPI7; -.
DR   OMA; RAMGVMW; -.
DR   OrthoDB; 1219117at2759; -.
DR   PhylomeDB; Q5PPI7; -.
DR   TreeFam; TF321143; -.
DR   PRO; PR:Q5PPI7; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000022283; Expressed in cerebellum and 7 other tissues.
DR   GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0032421; C:stereocilium bundle; ISO:RGD.
DR   GO; GO:0032426; C:stereocilium tip; ISO:RGD.
DR   GO; GO:0060088; P:auditory receptor cell stereocilium organization; ISO:RGD.
DR   GO; GO:0050974; P:detection of mechanical stimulus involved in sensory perception; IBA:GO_Central.
DR   GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; ISO:RGD.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR   InterPro; IPR019372; LHFPL.
DR   PANTHER; PTHR12489; PTHR12489; 1.
DR   Pfam; PF10242; L_HMGIC_fpl; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..219
FT                   /note="LHFPL tetraspan subfamily member 5 protein"
FT                   /id="PRO_0000285924"
FT   TOPO_DOM        1..24
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..178
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..219
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  24186 MW;  9BFC49260AE9DD02 CRC64;
     MVKLLPAQEA AKIYHTNYVR NSRAVGVMWG TLTICFSVLV MALFIQPYWI GDSVSTPQAG
     YFGLFSYCVG NVLSSELICK GGPLDFSSIP SRAFKTAMFF VALAMFLIIG SIICFSLFFV
     CNTATVYKIC AWMQLAAATG LMIGCLVYPD GWDSSEVRRM CGEQTGKYTL GHCTIRWAFM
     LAILSIGDAL ILSFLAFVLG YRQDKLLPDD YKADGNEEV