LHPL6_MOUSE
ID LHPL6_MOUSE Reviewed; 200 AA.
AC Q8BM86; Q3T9G7; Q3TWU2;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=LHFPL tetraspan subfamily member 6 protein {ECO:0000250|UniProtKB:Q9Y693};
DE AltName: Full=Lipoma HMGIC fusion partner {ECO:0000312|MGI:MGI:1920048};
DE Flags: Precursor;
GN Name=Lhfpl6 {ECO:0000250|UniProtKB:Q9Y693};
GN Synonyms=Lhfp {ECO:0000312|MGI:MGI:1920048};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129, and C57BL/6J; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LHFP family. {ECO:0000305}.
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DR EMBL; AK034532; BAC28745.1; -; mRNA.
DR EMBL; AK159126; BAE34840.1; -; mRNA.
DR EMBL; AK159549; BAE35174.1; -; mRNA.
DR EMBL; AK172390; BAE42980.1; -; mRNA.
DR EMBL; AK172532; BAE43053.1; -; mRNA.
DR EMBL; BC052079; AAH52079.1; -; mRNA.
DR EMBL; BC095934; AAH95934.1; -; mRNA.
DR CCDS; CCDS17344.1; -.
DR RefSeq; NP_780595.1; NM_175386.3.
DR AlphaFoldDB; Q8BM86; -.
DR SMR; Q8BM86; -.
DR STRING; 10090.ENSMUSP00000056364; -.
DR PhosphoSitePlus; Q8BM86; -.
DR PaxDb; Q8BM86; -.
DR PeptideAtlas; Q8BM86; -.
DR PRIDE; Q8BM86; -.
DR ProteomicsDB; 252471; -.
DR Antibodypedia; 67484; 90 antibodies from 14 providers.
DR DNASU; 108927; -.
DR Ensembl; ENSMUST00000059562; ENSMUSP00000056364; ENSMUSG00000048332.
DR Ensembl; ENSMUST00000147139; ENSMUSP00000119019; ENSMUSG00000048332.
DR GeneID; 108927; -.
DR KEGG; mmu:108927; -.
DR UCSC; uc008pep.1; mouse.
DR CTD; 108927; -.
DR MGI; MGI:1920048; Lhfp.
DR VEuPathDB; HostDB:ENSMUSG00000048332; -.
DR eggNOG; KOG4026; Eukaryota.
DR GeneTree; ENSGT00990000203589; -.
DR HOGENOM; CLU_084868_2_0_1; -.
DR InParanoid; Q8BM86; -.
DR OMA; ITVMVEQ; -.
DR OrthoDB; 1383327at2759; -.
DR PhylomeDB; Q8BM86; -.
DR TreeFam; TF321143; -.
DR BioGRID-ORCS; 108927; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Lhfp; mouse.
DR PRO; PR:Q8BM86; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BM86; protein.
DR Bgee; ENSMUSG00000048332; Expressed in ascending aorta and 233 other tissues.
DR Genevisible; Q8BM86; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR019372; LHFPL.
DR PANTHER; PTHR12489; PTHR12489; 1.
DR Pfam; PF10242; L_HMGIC_fpl; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..200
FT /note="LHFPL tetraspan subfamily member 6 protein"
FT /id="PRO_0000244757"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 95
FT /note="L -> P (in Ref. 2; BAE35174)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 200 AA; 21626 MW; B79B02170291C9A1 CRC64;
MASSLTCTGV IWALLSFLSA ATSCVGFFMP YWLWGSQLGK PVSFGTFRRC SYPVHDESRQ
MMVMVEECGR YASFQGIPST EWRICTIVTG LGCGLLLLVA LTALMGCCVS ELISRTVGRV
AGGIQFLGGL LIGAGCALYP LGWDSEEVRQ TCGYISGQFD LGKCEIGWAY YCTGAGAAAA
MLLCTWMACF SGKKQKHYPY
