LHPL7_HUMAN
ID LHPL7_HUMAN Reviewed; 200 AA.
AC Q6ICI0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=LHFPL tetraspan subfamily member 7 protein {ECO:0000305};
DE AltName: Full=Transmembrane protein 211;
GN Name=LHFPL7 {ECO:0000312|HGNC:HGNC:33725}; Synonyms=TMEM211;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-200.
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-200.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM211 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI30648.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI30650.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAG30274.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL050312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR456388; CAG30274.1; ALT_INIT; mRNA.
DR EMBL; BC130647; AAI30648.1; ALT_INIT; mRNA.
DR EMBL; BC130649; AAI30650.1; ALT_INIT; mRNA.
DR RefSeq; NP_001001663.1; NM_001001663.1.
DR AlphaFoldDB; Q6ICI0; -.
DR SMR; Q6ICI0; -.
DR STRING; 9606.ENSP00000385494; -.
DR PhosphoSitePlus; Q6ICI0; -.
DR BioMuta; TMEM211; -.
DR DMDM; 189037061; -.
DR PaxDb; Q6ICI0; -.
DR PeptideAtlas; Q6ICI0; -.
DR PRIDE; Q6ICI0; -.
DR Antibodypedia; 74015; 4 antibodies from 4 providers.
DR DNASU; 255349; -.
DR Ensembl; ENST00000423535.1; ENSP00000387813.1; ENSG00000206069.7.
DR Ensembl; ENST00000640159.2; ENSP00000492160.1; ENSG00000206069.7.
DR GeneID; 255349; -.
DR KEGG; hsa:255349; -.
DR MANE-Select; ENST00000640159.2; ENSP00000492160.1; NM_001388199.1; NP_001375128.1.
DR UCSC; uc003abk.2; human.
DR CTD; 255349; -.
DR GeneCards; TMEM211; -.
DR HGNC; HGNC:33725; LHFPL7.
DR HPA; ENSG00000206069; Tissue enhanced (cervix, salivary gland, stomach).
DR neXtProt; NX_Q6ICI0; -.
DR OpenTargets; ENSG00000206069; -.
DR VEuPathDB; HostDB:ENSG00000206069; -.
DR eggNOG; KOG4026; Eukaryota.
DR GeneTree; ENSGT00990000203589; -.
DR HOGENOM; CLU_1421051_0_0_1; -.
DR InParanoid; Q6ICI0; -.
DR OMA; FAKEACG; -.
DR OrthoDB; 1449971at2759; -.
DR PhylomeDB; Q6ICI0; -.
DR TreeFam; TF343322; -.
DR PathwayCommons; Q6ICI0; -.
DR SignaLink; Q6ICI0; -.
DR BioGRID-ORCS; 255349; 14 hits in 1070 CRISPR screens.
DR GenomeRNAi; 255349; -.
DR Pharos; Q6ICI0; Tdark.
DR PRO; PR:Q6ICI0; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q6ICI0; protein.
DR Bgee; ENSG00000206069; Expressed in olfactory segment of nasal mucosa and 78 other tissues.
DR ExpressionAtlas; Q6ICI0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR019372; LHFPL.
DR PANTHER; PTHR12489; PTHR12489; 1.
DR Pfam; PF10242; L_HMGIC_fpl; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..200
FT /note="LHFPL tetraspan subfamily member 7 protein"
FT /id="PRO_0000337008"
FT TRANSMEM 5..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 200 AA; 21740 MW; 3C9726DC732096EF CRC64;
MLSSVWVALG LSLTCTSAFS LISPAWFQTP TFSFGILTYC SWPQGNSWNQ SCVTFSSLED
IPDFAWKVSA VMLLGGWLLL AFNAIFLLSW AVAPKGLCPR RSSVPMPGVQ AVAATAMIVG
LLIFPIGLAS PFIKEVCEAS SMYYGGKCRL GWGYMTAILN AVLASLLPII SWPHTTKVQG
RTIIFSSATE RIIFVPEMNK
