LHR_ECOLI
ID LHR_ECOLI Reviewed; 1538 AA.
AC P30015;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Probable ATP-dependent helicase Lhr;
DE EC=3.6.4.-;
DE AltName: Full=Large helicase-related protein;
GN Name=lhr; Synonyms=rhlF; OrderedLocusNames=b1653, JW1645;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=7559321; DOI=10.1128/jb.177.19.5393-5400.1995;
RA Reuven N.B., Koonin E.V., Rudd K.E., Deutscher M.P.;
RT "The gene for the longest known Escherichia coli protein is a member of
RT helicase superfamily II.";
RL J. Bacteriol. 177:5393-5400(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-130.
RC STRAIN=K12;
RX PubMed=1460056; DOI=10.1016/s0021-9258(19)74084-8;
RA Huang S., Deutscher M.P.;
RT "Sequence and transcriptional analysis of the Escherichia coli rnt gene
RT encoding RNase T.";
RL J. Biol. Chem. 267:25609-25613(1992).
CC -!- SIMILARITY: Belongs to the helicase family. {ECO:0000305}.
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DR EMBL; L01622; AAC37009.1; -; Genomic_DNA.
DR EMBL; U00096; AAC74725.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15419.1; -; Genomic_DNA.
DR PIR; G64922; G64922.
DR RefSeq; NP_416170.1; NC_000913.3.
DR RefSeq; WP_001310858.1; NZ_LN832404.1.
DR AlphaFoldDB; P30015; -.
DR SMR; P30015; -.
DR BioGRID; 4260268; 108.
DR DIP; DIP-10097N; -.
DR IntAct; P30015; 9.
DR STRING; 511145.b1653; -.
DR PaxDb; P30015; -.
DR PRIDE; P30015; -.
DR EnsemblBacteria; AAC74725; AAC74725; b1653.
DR EnsemblBacteria; BAA15419; BAA15419; BAA15419.
DR GeneID; 946156; -.
DR KEGG; ecj:JW1645; -.
DR KEGG; eco:b1653; -.
DR PATRIC; fig|1411691.4.peg.606; -.
DR EchoBASE; EB1510; -.
DR eggNOG; COG1201; Bacteria.
DR HOGENOM; CLU_002025_3_1_6; -.
DR InParanoid; P30015; -.
DR OMA; LPFWHGD; -.
DR PhylomeDB; P30015; -.
DR BioCyc; EcoCyc:EG11548-MON; -.
DR BioCyc; MetaCyc:EG11548-MON; -.
DR PRO; PR:P30015; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013701; DEAD/DEAH_assoc.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08494; DEAD_assoc; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT CHAIN 1..1538
FT /note="Probable ATP-dependent helicase Lhr"
FT /id="PRO_0000102193"
FT DOMAIN 38..235
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 284..462
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 1287..1312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 179..182
FT /note="DEVH box"
FT BINDING 51..58
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 1538 AA; 169381 MW; 563172B5FE3D826E CRC64;
MADNPDPSSL LPDVFSPATR DWFLRAFKQP TAVQPQTWHV AARSEHALVI APTGSGKTLA
AFLYALDRLF REGGEDTREA HKRKTSRILY ISPIKALGTD VQRNLQIPLK GIADERRRRG
ETEVNLRVGI RTGDTPAQER SKLTRNPPDI LITTPESLYL MLTSRARETL RGVETVIIDE
VHAVAGSKRG AHLALSLERL DALLHTSAQR IGLSATVRSA SDVAAFLGGD RPVTVVNPPA
MRHPQIRIVV PVANMDDVSS VASGTGEDSH AGREGSIWPY IETGILDEVL RHRSTIVFTN
SRGLAEKLTA RLNELYAARL QRSPSIAVDA AHFESTSGAT SNRVQSSDVF IARSHHGSVS
KEQRAITEQA LKSGELRCVV ATSSLELGID MGAVDLVIQV ATPLSVASGL QRIGRAGHQV
GGVSKGLFFP RTRRDLVDSA VIVECMFAGR LENLTPPHNP LDVLAQQTVA AAAMDALQVD
EWYSRVRRAA PWKDLPRRVF DATLDMLSGR YPSGDFSAFR PKLVWNRETG ILTARPGAQL
LAVTSGGTIP DRGMYSVLLP EGEEKAGSRR VGELDEEMVY ESRVNDIITL GATSWRIQQI
TRDQVIVTPA PGRSARLPFW RGEGNGRPAE LGEMIGDFLH LLADGAFFSG TIPPWLAEEN
TIANIQGLIE EQRNATGIVP GSRHLVLERC RDEIGDWRII LHSPYGRRVH EPWAVAIAGR
IHALWGADAS VVASDDGIVA RIPDTDGKLP DAAIFLFEPE KLLQIVREAV GSSALFAARF
RECAARALLM PGRTPGHRTP LWQQRLRASQ LLEIAQGYPD FPVILETLRE CLQDVYDLPA
LERLMRRLNG GEIQISDVTT TTPSPFATSL LFGYVAEFMY QSDAPLAERR ASVLSLDSEL
LRNLLGQVDP GELLDPQVIR QVEEELQRLA PGRRAKGEEG LFDLLRELGP MTVEDLAQRH
TGSSEEVASY LENLLAVKRI FPAMISGQER LACMDDAARL RDALGVRLPE SLPEIYLHRV
SYPLRDLFLR YLRAHALVTA EQLAHEFSLG IAIVEEQLQQ LREQGLVMNL QQDIWVSDEV
FRRLRLRSLQ AAREATRPVA ATTYARLLLE RQGVLPATDG SPALFASTSP GVYEGVDGVM
RVIEQLAGVG LPASLWESQI LPARVRDYSS EMLDELLATG AVIWSGQKKL GEDDGLVALH
LQEYAAESFT PAEADQANRS ALQQAIVAVL ADGGAWFAQQ ISQRIRDKIG ESVDLSALQE
ALWALVWQGV ITSDIWAPLR ALTRSSSNAR TSTRRSHRAR RGRPVYAQPV SPRVSYNTPN
LAGRWSLLQV EPLNDTERML ALAENMLDRY GIISRQAVIA ENIPGGFPSM QTLCRSMEDS
GRIMRGRFVE GLGGAQFAER LTIDRLRDLA TQATQTRHYT PVALSANDPA NVWGNLLPWP
AHPATLVPTR RAGALVVVSG GKLLLYLAQG GKKMLVWQEK EELLAPEVFH ALTTALRREP
RLRFTLTEVN DLPVRQTPMF TLLREAGFSS SPQGLDWG