ID   LHTL1_ARATH             Reviewed;         453 AA.
AC   Q9C733;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Lysine histidine transporter-like 1;
GN   OrderedLocusNames=At1g48640; ORFNames=F11I4.17;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RC   STRAIN=cv. C24;
RX   PubMed=15361141; DOI=10.1111/j.1365-313x.2004.02186.x;
RA   Lee Y.-H., Tegeder M.;
RT   "Selective expression of a novel high-affinity transport system for acidic
RT   and neutral amino acids in the tapetum cells of Arabidopsis flowers.";
RL   Plant J. 40:60-74(2004).
CC   -!- FUNCTION: Amino acid transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       Amino acid/auxin permease (AAAP) (TC 2.A.18.2) subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG60126.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC073555; AAG60126.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE32332.1; -; Genomic_DNA.
DR   RefSeq; NP_175297.2; NM_103760.3.
DR   AlphaFoldDB; Q9C733; -.
DR   SMR; Q9C733; -.
DR   STRING; 3702.AT1G48640.1; -.
DR   PaxDb; Q9C733; -.
DR   PRIDE; Q9C733; -.
DR   EnsemblPlants; AT1G48640.1; AT1G48640.1; AT1G48640.
DR   GeneID; 841286; -.
DR   Gramene; AT1G48640.1; AT1G48640.1; AT1G48640.
DR   KEGG; ath:AT1G48640; -.
DR   Araport; AT1G48640; -.
DR   TAIR; locus:2008154; AT1G48640.
DR   eggNOG; KOG1303; Eukaryota.
DR   HOGENOM; CLU_031160_0_0_1; -.
DR   InParanoid; Q9C733; -.
DR   OMA; CIMWLLI; -.
DR   OrthoDB; 570025at2759; -.
DR   PhylomeDB; Q9C733; -.
DR   PRO; PR:Q9C733; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C733; baseline and differential.
DR   Genevisible; Q9C733; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015172; F:acidic amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..453
FT                   /note="Lysine histidine transporter-like 1"
FT                   /id="PRO_0000387971"
FT   TOPO_DOM        1..44
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..164
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..187
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        209..231
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        253..276
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..318
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        340..359
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        383..385
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        409..412
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        434..453
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  50449 MW;  C17D0458A3B24B69 CRC64;
     MYIQMTDGVP PPPEQSSLDH RIDELERQKE IDDWLPITSS RNAKWWYSTF HNVTAMVGAG
     VLGLPFFMAQ LGWGPGIAVL ILSWIITLYT LWQMVEMHEM VPGKRFDRYH ELGQFAFGER
     LGLYIIVPQQ IIVEVGVCIV YMVTGGQSLK KFHEIACQDC SPIRLSFFIM IFASSHFVLS
     HLPNFNSISG VSLVAAVMSL SYSTIAWTAT AAKGVQEDVQ YGYKSGTTAS TVLSFFTGLG
     GIAFAYAGHN VVLEIQATIP STPSNPSKGP MWRGVVVAYV VVALCYFPVA LVGYGVFGNA
     VLDNVLMSLE TPVWAIATAN LFVVMHVIGS YQIFAMPVFD MVETFLVKKL NFKPSTVLRF
     IVRNVYVALT MFIGIMIPFF GGLLAFFGGF AFAPTSYFLP CIMWLLIYKP KRFSLSWWTN
     WVCIVLGVVL MILSSIGGLR QIIIQSKDYS FFS