LHTL2_ARATH
ID LHTL2_ARATH Reviewed; 441 AA.
AC Q9SR44; A0MEF0;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Lysine histidine transporter-like 2;
GN OrderedLocusNames=At1g67640; ORFNames=F12A21.22, F12B7.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY.
RC STRAIN=cv. C24;
RX PubMed=15361141; DOI=10.1111/j.1365-313x.2004.02186.x;
RA Lee Y.-H., Tegeder M.;
RT "Selective expression of a novel high-affinity transport system for acidic
RT and neutral amino acids in the tapetum cells of Arabidopsis flowers.";
RL Plant J. 40:60-74(2004).
CC -!- FUNCTION: Amino acid transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Amino acid/auxin permease (AAAP) (TC 2.A.18.2) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28455.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC008113; AAG28894.1; -; Genomic_DNA.
DR EMBL; AC011020; AAG52310.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34675.1; -; Genomic_DNA.
DR EMBL; DQ446407; ABE65751.1; -; mRNA.
DR EMBL; DQ652920; ABK28455.1; ALT_SEQ; mRNA.
DR RefSeq; NP_176932.1; NM_105432.2.
DR AlphaFoldDB; Q9SR44; -.
DR SMR; Q9SR44; -.
DR STRING; 3702.AT1G67640.1; -.
DR PaxDb; Q9SR44; -.
DR PRIDE; Q9SR44; -.
DR ProteomicsDB; 238604; -.
DR EnsemblPlants; AT1G67640.1; AT1G67640.1; AT1G67640.
DR GeneID; 843088; -.
DR Gramene; AT1G67640.1; AT1G67640.1; AT1G67640.
DR KEGG; ath:AT1G67640; -.
DR Araport; AT1G67640; -.
DR TAIR; locus:2008605; AT1G67640.
DR eggNOG; KOG1303; Eukaryota.
DR HOGENOM; CLU_031160_0_0_1; -.
DR InParanoid; Q9SR44; -.
DR OMA; GIAGMFW; -.
DR OrthoDB; 570025at2759; -.
DR PhylomeDB; Q9SR44; -.
DR PRO; PR:Q9SR44; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SR44; baseline and differential.
DR Genevisible; Q9SR44; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015172; F:acidic amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..441
FT /note="Lysine histidine transporter-like 2"
FT /id="PRO_0000387972"
FT TOPO_DOM 1..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..58
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..110
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..222
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..300
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 371..373
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 397..406
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..441
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 441 AA; 49421 MW; C6B85789C20AAAAB CRC64;
MEKSQSSPTK DASTKQKNVD DWLPITSSRN AKWWYSAFHN VTAMVGAGVL SLPYAMSNLG
WGPGVTIMIM SWLITFYTLW QMVQMHEMVP GKRFDRYHEL GQHAFGEKLG LWIVVPQQLI
VEVGVDIVYM VTGGKSLKKI HDLLCTDCKN IRTTYWIMIF ASIHFVLAHL PNFNSISIVS
LAAAVMSLSY STIAWATSVK KGVHPNVDYS SRASTTSGNV FNFLNALGDV AFAYAGHNVV
LEIQATIPST PEKPSKIAMW KGVVVAYIVV AICYFPVAFV CYYIFGNSVD DNILMTLEKP
IWLIAIANAF VVVHVIGSYQ IYAMPVFDML ETFLVKKMMF APSFKLRFIT RTLYVAFTMF
VAICIPFFGG LLGFFGGFAF APTTYYLPCI MWLCIKKPKK YGLSWCINWF CIVVGVILTI
LAPIGGLRTI IISAKNYEFF S