LHTL3_ARATH
ID LHTL3_ARATH Reviewed; 451 AA.
AC O22719;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Lysine histidine transporter-like 3;
GN OrderedLocusNames=At1g61270; ORFNames=F11P17.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RC STRAIN=cv. C24;
RX PubMed=15361141; DOI=10.1111/j.1365-313x.2004.02186.x;
RA Lee Y.-H., Tegeder M.;
RT "Selective expression of a novel high-affinity transport system for acidic
RT and neutral amino acids in the tapetum cells of Arabidopsis flowers.";
RL Plant J. 40:60-74(2004).
CC -!- FUNCTION: Amino acid transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Amino acid/auxin permease (AAAP) (TC 2.A.18.2) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB71468.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002294; AAB71468.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33815.1; -; Genomic_DNA.
DR RefSeq; NP_176322.1; NM_104808.2.
DR AlphaFoldDB; O22719; -.
DR SMR; O22719; -.
DR BioGRID; 27644; 1.
DR STRING; 3702.AT1G61270.1; -.
DR PaxDb; O22719; -.
DR PRIDE; O22719; -.
DR EnsemblPlants; AT1G61270.1; AT1G61270.1; AT1G61270.
DR GeneID; 842421; -.
DR Gramene; AT1G61270.1; AT1G61270.1; AT1G61270.
DR KEGG; ath:AT1G61270; -.
DR Araport; AT1G61270; -.
DR TAIR; locus:2008435; AT1G61270.
DR eggNOG; KOG1303; Eukaryota.
DR HOGENOM; CLU_031160_0_0_1; -.
DR InParanoid; O22719; -.
DR OMA; FWQMIEM; -.
DR OrthoDB; 570025at2759; -.
DR PhylomeDB; O22719; -.
DR PRO; PR:O22719; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O22719; baseline and differential.
DR Genevisible; O22719; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015172; F:acidic amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015180; F:L-alanine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015183; F:L-aspartate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005313; F:L-glutamate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0015808; P:L-alanine transport; IBA:GO_Central.
DR GO; GO:0070778; P:L-aspartate transmembrane transport; IBA:GO_Central.
DR GO; GO:0098712; P:L-glutamate import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..451
FT /note="Lysine histidine transporter-like 3"
FT /id="PRO_0000387973"
FT TOPO_DOM 1..40
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..63
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..159
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..227
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 331..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 380
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..413
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 435..451
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 451 AA; 50326 MW; 949DE600442F66E1 CRC64;
MKGIPSSSNQ ILNQDLVEDQ SFELEDWLPI TASRNANWYY SAFHNVTAIV GAGVLGLPYA
MSELGWGPGV VVLILSWVIT LYTFWQMIEM HEMFEGKRFD RYHELGQAAF GKKLGLYIVV
PLQLLVETSA CIVYMVTGGE SLKKIHQLSV GDYECRKLKV RHFILIFASS QFVLSLLKNF
NSISGVSLVA AVMSMSYSTI AWVASLTKGV ANNVEYGYKR RNNTSVPLAF LGALGEMAFA
YAGHNVVLEI QATIPSTPEN PSKRPMWKGA IVAYIIVAFC YFPVALVGFW TFGNNVEENI
LKTLRGPKGL IIVANIFVII HLMGSYQVYA MPVFDMIESV MIKKWHFSPT RVLRFTIRWT
FVAATMGIAV ALPHFSALLS FFGGFIFAPT TYFIPCIIWL ILKKPKRFSL SWCINWICII
LGVLVMIIAP IGGLAKLMNA LKQPDSSCKS T
