LHTL4_ARATH
ID LHTL4_ARATH Reviewed; 455 AA.
AC Q9SS86; Q9SGJ3;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Lysine histidine transporter-like 4;
GN OrderedLocusNames=At3g01760; ORFNames=F28J7.9, F4P13.31;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RC STRAIN=cv. C24;
RX PubMed=15361141; DOI=10.1111/j.1365-313x.2004.02186.x;
RA Lee Y.-H., Tegeder M.;
RT "Selective expression of a novel high-affinity transport system for acidic
RT and neutral amino acids in the tapetum cells of Arabidopsis flowers.";
RL Plant J. 40:60-74(2004).
CC -!- FUNCTION: Amino acid transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Amino acid/auxin permease (AAAP) (TC 2.A.18.2) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF01559.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009325; AAF01559.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC010797; AAF03432.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE73711.1; -; Genomic_DNA.
DR RefSeq; NP_186825.2; NM_111042.3.
DR AlphaFoldDB; Q9SS86; -.
DR SMR; Q9SS86; -.
DR STRING; 3702.AT3G01760.1; -.
DR PaxDb; Q9SS86; -.
DR PRIDE; Q9SS86; -.
DR ProteomicsDB; 238448; -.
DR EnsemblPlants; AT3G01760.1; AT3G01760.1; AT3G01760.
DR GeneID; 821086; -.
DR Gramene; AT3G01760.1; AT3G01760.1; AT3G01760.
DR KEGG; ath:AT3G01760; -.
DR Araport; AT3G01760; -.
DR TAIR; locus:2082354; AT3G01760.
DR eggNOG; KOG1303; Eukaryota.
DR HOGENOM; CLU_031160_0_0_1; -.
DR InParanoid; Q9SS86; -.
DR OMA; ESVMIRI; -.
DR OrthoDB; 570025at2759; -.
DR PhylomeDB; Q9SS86; -.
DR PRO; PR:Q9SS86; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SS86; baseline and differential.
DR Genevisible; Q9SS86; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015172; F:acidic amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015180; F:L-alanine transmembrane transporter activity; IMP:TAIR.
DR GO; GO:0015183; F:L-aspartate transmembrane transporter activity; IMP:TAIR.
DR GO; GO:0005313; F:L-glutamate transmembrane transporter activity; IMP:TAIR.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0015808; P:L-alanine transport; IMP:TAIR.
DR GO; GO:0070778; P:L-aspartate transmembrane transport; IMP:TAIR.
DR GO; GO:0098712; P:L-glutamate import across plasma membrane; IMP:TAIR.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..455
FT /note="Lysine histidine transporter-like 4"
FT /id="PRO_0000387974"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..158
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..226
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..267
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..307
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 379
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..412
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 434..455
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 455 AA; 50736 MW; 90F9FCC3E86F9F26 CRC64;
MAGIPDHIQD QHLVEEDQPF DLEDWLPITA SRNANWYYSA FHNVTAIVGA GVLGLPYAMS
ELGWGPGVVV LILSWVITLY TLWQMIEMHE MFEGQRFDRY HELGQAAFGK KLGLYIIVPL
QLLVEISVCI VYMVTGGKSL KNVHDLALGD GDKCTKLRIQ HFILIFASSQ FVLSLLKNFN
SISGVSLVAA VMSVSYSTIA WVASLRKGAT TGSVEYGYRK RTTSVPLAFL SALGEMAFAY
AGHNVVLEIQ ATIPSTPENP SKRPMWKGAV VAYIIVAFCY FPVALVGFKT FGNSVEESIL
ESLTKPTALV IVANMFVVIH LLGSYQVYAM PVFDMIESVM IRIWHFSPTR VLRFTIRWTF
VAATMGIAVG LPYYSALLSF FGGFVFAPTT YFIPCIMWLI LKKPKRFSLS WCMNWFCIIF
GLVLMIIAPI GGLAKLIYNI QKGTLPNSRC NLPKH
