ID   LHTL5_ARATH             Reviewed;         448 AA.
AC   Q9C9J0; Q9M9H9;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Lysine histidine transporter-like 5;
GN   OrderedLocusNames=At1g71680; ORFNames=F14O23.2, F26A9.9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RC   STRAIN=cv. C24;
RX   PubMed=15361141; DOI=10.1111/j.1365-313x.2004.02186.x;
RA   Lee Y.-H., Tegeder M.;
RT   "Selective expression of a novel high-affinity transport system for acidic
RT   and neutral amino acids in the tapetum cells of Arabidopsis flowers.";
RL   Plant J. 40:60-74(2004).
CC   -!- FUNCTION: Amino acid transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       Amino acid/auxin permease (AAAP) (TC 2.A.18.2) subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF43217.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAG51818.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC012654; AAF43217.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC016163; AAG51818.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE35212.1; -; Genomic_DNA.
DR   PIR; E96738; E96738.
DR   RefSeq; NP_565019.2; NM_105822.3.
DR   AlphaFoldDB; Q9C9J0; -.
DR   SMR; Q9C9J0; -.
DR   STRING; 3702.AT1G71680.1; -.
DR   iPTMnet; Q9C9J0; -.
DR   PaxDb; Q9C9J0; -.
DR   PRIDE; Q9C9J0; -.
DR   ProteomicsDB; 238658; -.
DR   EnsemblPlants; AT1G71680.1; AT1G71680.1; AT1G71680.
DR   GeneID; 843494; -.
DR   Gramene; AT1G71680.1; AT1G71680.1; AT1G71680.
DR   KEGG; ath:AT1G71680; -.
DR   Araport; AT1G71680; -.
DR   TAIR; locus:2013056; AT1G71680.
DR   eggNOG; KOG1303; Eukaryota.
DR   HOGENOM; CLU_031160_0_0_1; -.
DR   InParanoid; Q9C9J0; -.
DR   OMA; IANLMVF; -.
DR   OrthoDB; 570025at2759; -.
DR   PhylomeDB; Q9C9J0; -.
DR   PRO; PR:Q9C9J0; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C9J0; baseline and differential.
DR   Genevisible; Q9C9J0; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..448
FT                   /note="Lysine histidine transporter-like 5"
FT                   /id="PRO_0000387975"
FT   TOPO_DOM        1..41
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..155
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..183
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..222
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..269
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..313
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        335..361
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        404..411
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        433..448
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   448 AA;  49794 MW;  3FF31380A84D1A44 CRC64;
     MTYTANDEEN KGRSTDNNNH RQMDYNDWLP VTASREAKWY YSAFHNVTAM VGAGVLGLPF
     AMSQLGWGPG LVAIIMSWAI TFYSLWQMVQ LHEAVPGKRL DRYPELGQEA FGPKLGYWIV
     MPQQLLVQIA SDIVYNVTGG KSLKKFVELL FPNLEHIRQT YYILGFAALQ LVLSQSPDFN
     SIKIVSLLAA LMSFLYSMIA SVASIAKGTE HRPSTYGVRG DTVASMVFDA FNGIGTIAFA
     FAGHSVVLEI QATIPSTPEV PSKKPMWKGV VVAYIIVIIC YLFVAISGYW AFGAHVEDDV
     LISLERPAWL IAAANFMVFI HVIGSYQVFA MIVFDTIESY LVKTLKFTPS TTLRLVARST
     YVALICLVAV CIPFFGGLLG FFGGLVFSST SYFLPCIIWL IMKRPKRFSA HWWCSWVAIV
     TGISIAILAP IGGMRHIILS ARTYKLFS