LHWL2_ARATH
ID LHWL2_ARATH Reviewed; 527 AA.
AC Q7XJU0; B3H7K3; C0SV15; Q9SGV2;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Transcription factor bHLH157;
DE AltName: Full=BHLH transcription factor epsilon;
DE Short=bHLH epsilon;
DE AltName: Full=Basic helix-loop-helix protein 157;
DE Short=AtbHLH157;
DE Short=bHLH 157;
DE AltName: Full=LONESOME HIGHWAY-like protein 2;
DE AltName: Full=bHLH transcription factor bHLH157;
GN Name=BHLH157; OrderedLocusNames=At1g64625; ORFNames=F1N19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=17626058; DOI=10.1242/dev.006296;
RA Ohashi-Ito K., Bergmann D.C.;
RT "Regulation of the Arabidopsis root vascular initial population by LONESOME
RT HIGHWAY.";
RL Development 134:2959-2968(2007).
CC -!- FUNCTION: Transcription factor that may regulate root development.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- INTERACTION:
CC Q7XJU0-2; Q9FY69: BHLH143; NbExp=3; IntAct=EBI-15196985, EBI-15194247;
CC Q7XJU0-2; Q570R7: BHLH72; NbExp=3; IntAct=EBI-15196985, EBI-1638784;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7XJU0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7XJU0-2; Sequence=VSP_035527;
CC -!- SIMILARITY: Belongs to the bHLH protein family. LHW subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF19679.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g64630 has been split into 2 genes: At1g64625 and At1g64630.; Evidence={ECO:0000305};
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DR EMBL; AJ576044; CAE09171.1; -; mRNA.
DR EMBL; AC009519; AAF19679.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34263.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34264.1; -; Genomic_DNA.
DR EMBL; AB493518; BAH30356.1; -; mRNA.
DR RefSeq; NP_001117547.1; NM_001124075.2. [Q7XJU0-2]
DR RefSeq; NP_849917.2; NM_179586.3. [Q7XJU0-1]
DR AlphaFoldDB; Q7XJU0; -.
DR SMR; Q7XJU0; -.
DR BioGRID; 29659; 14.
DR IntAct; Q7XJU0; 14.
DR STRING; 3702.AT1G64625.1; -.
DR PaxDb; Q7XJU0; -.
DR PRIDE; Q7XJU0; -.
DR EnsemblPlants; AT1G64625.1; AT1G64625.1; AT1G64625. [Q7XJU0-1]
DR EnsemblPlants; AT1G64625.2; AT1G64625.2; AT1G64625. [Q7XJU0-2]
DR GeneID; 844441; -.
DR Gramene; AT1G64625.1; AT1G64625.1; AT1G64625. [Q7XJU0-1]
DR Gramene; AT1G64625.2; AT1G64625.2; AT1G64625. [Q7XJU0-2]
DR KEGG; ath:AT1G64625; -.
DR Araport; AT1G64625; -.
DR TAIR; locus:1005716759; AT1G64625.
DR eggNOG; ENOG502QQES; Eukaryota.
DR HOGENOM; CLU_574101_0_0_1; -.
DR InParanoid; Q7XJU0; -.
DR OMA; DDCCSLN; -.
DR OrthoDB; 673999at2759; -.
DR PhylomeDB; Q7XJU0; -.
DR PRO; PR:Q7XJU0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q7XJU0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0071365; P:cellular response to auxin stimulus; IEP:TAIR.
DR GO; GO:0007140; P:male meiotic nuclear division; IMP:TAIR.
DR GO; GO:0051321; P:meiotic cell cycle; IMP:TAIR.
DR GO; GO:0090058; P:metaxylem development; IMP:TAIR.
DR GO; GO:0048364; P:root development; ISS:UniProtKB.
DR GO; GO:0048316; P:seed development; IMP:TAIR.
DR GO; GO:0010089; P:xylem development; IGI:TAIR.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR043561; LHW-like.
DR InterPro; IPR025610; MYC/MYB_N.
DR PANTHER; PTHR46196; PTHR46196; 2.
DR Pfam; PF14215; bHLH-MYC_N; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..527
FT /note="Transcription factor bHLH157"
FT /id="PRO_0000351658"
FT DOMAIN 354..403
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 295..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 341..348
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT VAR_SEQ 98..107
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_035527"
SQ SEQUENCE 527 AA; 59576 MW; D071F605E9795198 CRC64;
MGSEYKHILK SLCLSHGWSY AVFWRYDPIN SMILRFEEAY NDEQSVALVD DMVLQAPILG
QGIVGEVASS GNHQWLFSDT LFQWEHEFQN QFLCGFKILI RQFTYTQTIA IIPLGSSGVV
QLGSTQKILE STEILEQTTR ALQETCLKPH DSGDLDTLFE SLGDCEIFPA ESFQGFSFDD
IFAEDNPPSL LSPEMISSEA ASSNQDLTNG DDYGFDILQS YSLDDLYQLL ADPPEQNCSS
MVIQGVDKDL FDILGMNSQT PTMALPPKGL FSELISSSLS NNTCSSSLTN VQEYSGVNQS
KRRKLDTSSA HSSSLFPQEE TVTSRSLWID DDERSSIGGN WKKPHEEGVK KKRAKAGESR
RPRPKDRQMI QDRIKELRGM IPNGAKCSID TLLDLTIKHM VFMQSLAKYA ERLKQPYESK
LVKEKERTWA LEVGEEGVVC PIMVEELNRE GEMQIEMVCE EREEFLEIGQ VVRGLGLKIL
KGVMETRKGQ IWAHFIVQAK PQVTRIQVLY SLVQLFQHHT KHDDLLS
