LHX1_DANRE
ID LHX1_DANRE Reviewed; 405 AA.
AC Q90476;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=LIM/homeobox protein Lhx1;
DE Short=LIM homeobox protein 1;
DE AltName: Full=Homeobox protein Lim-1;
GN Name=lhx1a; Synonyms=lhx1, lim1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC TISSUE=Neurula;
RX PubMed=7768180; DOI=10.1242/dev.121.2.383;
RA Toyama R., O'Connell M.L., Wright C.V.E., Kuehn M.R., Dawid I.B.;
RT "Nodal induces ectopic goosecoid and lim1 expression and axis duplication
RT in zebrafish.";
RL Development 121:383-391(1995).
CC -!- FUNCTION: Seems to play a role in dorsal axis formation.
CC {ECO:0000269|PubMed:7768180}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Detected 4 hours after fertilization with maximum
CC levels seen in 6 hours embryos. Expression then declines during
CC gastrulation (6-10 hours), but is still detectable in 24 and 30 hours
CC embryos. The spatial distribution also varies during embryogenesis: at
CC the beginning, expression is localized in deep cells and is absent from
CC the enveloping layer. The pattern then becomes asymmetric, restricting
CC to the forming embryonic shield. By the shield stage, it is highly
CC localized in the axial hypoblast. As gastrulation proceeds, expression
CC continues in the involuting cells, extending from the margin towards
CC the anterior. {ECO:0000269|PubMed:7768180}.
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DR EMBL; L37802; AAA92157.1; -; mRNA.
DR RefSeq; NP_571291.1; NM_131216.1.
DR AlphaFoldDB; Q90476; -.
DR SMR; Q90476; -.
DR STRING; 7955.ENSDARP00000021069; -.
DR PaxDb; Q90476; -.
DR Ensembl; ENSDART00000005641; ENSDARP00000021069; ENSDARG00000014018.
DR GeneID; 30463; -.
DR KEGG; dre:30463; -.
DR CTD; 30463; -.
DR ZFIN; ZDB-GENE-980526-347; lhx1a.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000164085; -.
DR HOGENOM; CLU_027802_3_1_1; -.
DR InParanoid; Q90476; -.
DR OMA; QSEYYAP; -.
DR OrthoDB; 1070389at2759; -.
DR PhylomeDB; Q90476; -.
DR TreeFam; TF315442; -.
DR PRO; PR:Q90476; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 15.
DR Bgee; ENSDARG00000014018; Expressed in brain and 48 other tissues.
DR ExpressionAtlas; Q90476; baseline.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; ISS:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; ISS:UniProtKB.
DR GO; GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; ISS:UniProtKB.
DR GO; GO:0021937; P:cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; ISS:UniProtKB.
DR GO; GO:0021549; P:cerebellum development; ISS:UniProtKB.
DR GO; GO:0072049; P:comma-shaped body morphogenesis; ISS:UniProtKB.
DR GO; GO:0097379; P:dorsal spinal cord interneuron posterior axon guidance; ISS:UniProtKB.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR GO; GO:0001705; P:ectoderm formation; ISS:UniProtKB.
DR GO; GO:0009880; P:embryonic pattern specification; ISS:UniProtKB.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; ISS:UniProtKB.
DR GO; GO:0001706; P:endoderm formation; ISS:UniProtKB.
DR GO; GO:0060429; P:epithelium development; ISS:UniProtKB.
DR GO; GO:0021871; P:forebrain regionalization; ISS:UniProtKB.
DR GO; GO:0001702; P:gastrulation with mouth forming second; ISS:UniProtKB.
DR GO; GO:0060322; P:head development; ISS:UniProtKB.
DR GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR GO; GO:0097477; P:lateral motor column neuron migration; ISS:UniProtKB.
DR GO; GO:0008045; P:motor neuron axon guidance; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0072178; P:nephric duct morphogenesis; ISS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0061205; P:paramesonephric duct development; ISS:UniProtKB.
DR GO; GO:0007389; P:pattern specification process; ISS:UniProtKB.
DR GO; GO:2000744; P:positive regulation of anterior head development; ISS:UniProtKB.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0040019; P:positive regulation of embryonic development; ISS:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
DR GO; GO:2000768; P:positive regulation of nephron tubule epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0009791; P:post-embryonic development; ISS:UniProtKB.
DR GO; GO:0090009; P:primitive streak formation; ISS:UniProtKB.
DR GO; GO:0010468; P:regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0072077; P:renal vesicle morphogenesis; ISS:UniProtKB.
DR GO; GO:0010842; P:retina layer formation; ISS:UniProtKB.
DR GO; GO:0072050; P:S-shaped body morphogenesis; ISS:UniProtKB.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; ISS:UniProtKB.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0001657; P:ureteric bud development; ISS:UniProtKB.
DR GO; GO:0001655; P:urogenital system development; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Zinc.
FT CHAIN 1..405
FT /note="LIM/homeobox protein Lhx1"
FT /id="PRO_0000075776"
FT DOMAIN 4..54
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 63..117
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 179..238
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 158..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 405 AA; 45154 MW; 186EEBEB59C88123 CRC64;
MVHCAGCERP ILDRFLLNVL DRAWHIKCVQ CCECKCNLTE KCFSREGKLY CKNDFFRRFG
TKCAGCAQGI SPNDLVRRAR SKVFHLNCFT CMMCNKQLST GEELYIIDEN KFVCKDDYLS
NTNGKDSNLL SVTACSDPSL SPDSQDQLQD DVKDAEIANL SDKETGNNEN DDQNLGGKRR
GPRTTIKAKQ LETLKAAFAA TPKPTRHIRE QLAQETGLNM RVIQVWFQNR RSKERRMKQL
SALGARRHAF FRSPRRMRTL VDRLEPGELI PNGPFSYYGD YQSEYYGPGG NYDFFPQGPP
SSQAQTPVDL PFVPSSGPTG TPLGGMDHPI PGHHPSSEVQ RFSDIMSHHP GDSPSPEPGI
PGPLHSMSSD VFGPSPSFTS LSLNGSGYSN HLSHPPSEMN EGTVW
