LHX1_RAT
ID LHX1_RAT Reviewed; 406 AA.
AC P63007; P36199;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=LIM/homeobox protein Lhx1;
DE Short=LIM homeobox protein 1;
DE AltName: Full=Homeobox protein Lim-1;
DE Short=Rlim;
GN Name=Lhx1; Synonyms=Lim-1, Lim1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=7914684; DOI=10.1016/0304-3940(94)90334-4;
RA Furuyama T., Inagaki S., Iwahashi Y., Takagi H.;
RT "Distribution of Rlim, an LIM homeodomain gene, in the rat brain.";
RL Neurosci. Lett. 170:266-268(1994).
RN [2]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=8793615;
RA Karavanov A.A., Saint-Jeannet J.P., Karavanova I., Taira M., Dawid I.B.;
RT "The LIM homeodomain protein Lim-1 is widely expressed in neural, neural
RT crest and mesoderm derivatives in vertebrate development.";
RL Int. J. Dev. Biol. 40:453-461(1996).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Potential transcription factor. May play a role in early
CC mesoderm formation and later in lateral mesoderm differentiation and
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with LDB1 via the tandem LIM domains. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:7914684, ECO:0000269|PubMed:8793615}.
CC -!- TISSUE SPECIFICITY: Expressed in epithelial structures of the embryonic
CC metanephric kidneys including the ureteric bud and its derivatives, and
CC coma-shaped and S-shaped bodies differentiating from the metanephric
CC mesenchyme. In the adult brain, expressed in the adrenal medulla,
CC Purkinje cells of the cerebellum, hypothalamus, midbrain and pons. Also
CC expressed in the adult testis. {ECO:0000269|PubMed:7914684,
CC ECO:0000269|PubMed:8793615}.
CC -!- DOMAIN: The LIM domains exert a negative regulatory function and
CC disruption of the LIM domains produces an activated form. In addition,
CC two activation domains and a negative regulatory domain exist C-
CC terminally to the homeobox (By similarity). {ECO:0000250}.
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DR EMBL; S71523; AAC60696.1; -; mRNA.
DR RefSeq; NP_665887.3; NM_145880.3.
DR AlphaFoldDB; P63007; -.
DR SMR; P63007; -.
DR STRING; 10116.ENSRNOP00000003799; -.
DR iPTMnet; P63007; -.
DR PhosphoSitePlus; P63007; -.
DR PaxDb; P63007; -.
DR Ensembl; ENSRNOT00000003799; ENSRNOP00000003799; ENSRNOG00000002812.
DR GeneID; 257634; -.
DR KEGG; rno:257634; -.
DR CTD; 3975; -.
DR RGD; 71074; Lhx1.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000160834; -.
DR HOGENOM; CLU_027802_3_1_1; -.
DR InParanoid; P63007; -.
DR OMA; QSEYYAP; -.
DR OrthoDB; 1070389at2759; -.
DR PhylomeDB; P63007; -.
DR TreeFam; TF315442; -.
DR PRO; PR:P63007; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000002812; Expressed in cerebellum and 3 other tissues.
DR Genevisible; P63007; RN.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; ISS:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; ISS:UniProtKB.
DR GO; GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB.
DR GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEP:UniProtKB.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; ISS:UniProtKB.
DR GO; GO:0021937; P:cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; ISS:UniProtKB.
DR GO; GO:0021549; P:cerebellum development; ISS:UniProtKB.
DR GO; GO:0060067; P:cervix development; ISS:UniProtKB.
DR GO; GO:0072049; P:comma-shaped body morphogenesis; ISS:UniProtKB.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR GO; GO:0001705; P:ectoderm formation; ISS:UniProtKB.
DR GO; GO:0009880; P:embryonic pattern specification; ISS:UniProtKB.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; ISS:UniProtKB.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; ISS:UniProtKB.
DR GO; GO:0007492; P:endoderm development; ISO:RGD.
DR GO; GO:0001706; P:endoderm formation; ISS:UniProtKB.
DR GO; GO:0060429; P:epithelium development; ISS:UniProtKB.
DR GO; GO:0021871; P:forebrain regionalization; ISS:UniProtKB.
DR GO; GO:0001702; P:gastrulation with mouth forming second; ISS:UniProtKB.
DR GO; GO:0060322; P:head development; ISS:UniProtKB.
DR GO; GO:0035852; P:horizontal cell localization; ISO:RGD.
DR GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR GO; GO:0097477; P:lateral motor column neuron migration; ISS:UniProtKB.
DR GO; GO:0048382; P:mesendoderm development; ISO:RGD.
DR GO; GO:0072177; P:mesonephric duct development; IEP:UniProtKB.
DR GO; GO:0072164; P:mesonephric tubule development; IEP:UniProtKB.
DR GO; GO:0001823; P:mesonephros development; ISO:RGD.
DR GO; GO:0072278; P:metanephric comma-shaped body morphogenesis; IEP:UniProtKB.
DR GO; GO:0072224; P:metanephric glomerulus development; IEP:UniProtKB.
DR GO; GO:0035502; P:metanephric part of ureteric bud development; IEP:UniProtKB.
DR GO; GO:0072283; P:metanephric renal vesicle morphogenesis; ISO:RGD.
DR GO; GO:0072284; P:metanephric S-shaped body morphogenesis; IEP:UniProtKB.
DR GO; GO:0001656; P:metanephros development; ISO:RGD.
DR GO; GO:0008045; P:motor neuron axon guidance; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0035849; P:nephric duct elongation; ISO:RGD.
DR GO; GO:0072178; P:nephric duct morphogenesis; ISS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0060066; P:oviduct development; ISS:UniProtKB.
DR GO; GO:0035846; P:oviduct epithelium development; ISS:UniProtKB.
DR GO; GO:0061205; P:paramesonephric duct development; ISS:UniProtKB.
DR GO; GO:0007389; P:pattern specification process; ISS:UniProtKB.
DR GO; GO:2000744; P:positive regulation of anterior head development; ISS:UniProtKB.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0040019; P:positive regulation of embryonic development; ISS:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
DR GO; GO:2000768; P:positive regulation of nephron tubule epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0009791; P:post-embryonic development; ISS:UniProtKB.
DR GO; GO:0090009; P:primitive streak formation; ISS:UniProtKB.
DR GO; GO:0048793; P:pronephros development; ISO:RGD.
DR GO; GO:0010468; P:regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0072077; P:renal vesicle morphogenesis; ISS:UniProtKB.
DR GO; GO:0060041; P:retina development in camera-type eye; ISO:RGD.
DR GO; GO:0010842; P:retina layer formation; ISS:UniProtKB.
DR GO; GO:0072050; P:S-shaped body morphogenesis; ISS:UniProtKB.
DR GO; GO:0032525; P:somite rostral/caudal axis specification; ISO:RGD.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; ISS:UniProtKB.
DR GO; GO:0021510; P:spinal cord development; ISO:RGD.
DR GO; GO:0021537; P:telencephalon development; ISO:RGD.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0072197; P:ureter morphogenesis; ISO:RGD.
DR GO; GO:0001657; P:ureteric bud development; ISS:UniProtKB.
DR GO; GO:0001655; P:urogenital system development; ISS:UniProtKB.
DR GO; GO:0035847; P:uterine epithelium development; ISS:UniProtKB.
DR GO; GO:0060065; P:uterus development; ISS:UniProtKB.
DR GO; GO:0060068; P:vagina development; ISS:UniProtKB.
DR GO; GO:0021517; P:ventral spinal cord development; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox; LIM domain;
KW Metal-binding; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..406
FT /note="LIM/homeobox protein Lhx1"
FT /id="PRO_0000075773"
FT DOMAIN 4..54
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 63..117
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 180..239
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 128..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 406 AA; 44780 MW; CC8637984998ADAF CRC64;
MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY CKNDFFRCFG
TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST GEELYIIDEN KFVCKEDYLS
NSSVAKENSL HSATTGSDPS LSPDSQDPSQ DDAKDSESAN VSDKEGGSNE NDDQNLGAKR
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ
LSALGARRHA FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP
PSSQAQTPVD LPFVPSSGPS GTPLGGLDHP LPGHHPSSEA QRFTDILAHP PGDSPSPEPS
LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM NEAAVW
