LHX1_SAIBB
ID LHX1_SAIBB Reviewed; 406 AA.
AC Q5IS89;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=LIM/homeobox protein Lhx1;
DE Short=LIM homeobox protein 1;
DE AltName: Full=Homeobox protein Lim-1;
GN Name=LHX1;
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT "Accelerated evolution of nervous system genes in the origin of Homo
RT sapiens.";
RL Cell 119:1027-1040(2004).
CC -!- FUNCTION: Potential transcription factor. May play a role in early
CC mesoderm formation and later in lateral mesoderm differentiation and
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with LDB1 via the tandem LIM domains. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DOMAIN: The LIM domains exert a negative regulatory function and
CC disruption of the LIM domains produces an activated form. In addition,
CC two activation domains and a negative regulatory domain exist C-
CC terminally to the homeobox (By similarity). {ECO:0000250}.
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DR EMBL; AY665239; AAV74277.1; -; mRNA.
DR RefSeq; NP_001266932.1; NM_001280003.1.
DR AlphaFoldDB; Q5IS89; -.
DR SMR; Q5IS89; -.
DR STRING; 39432.ENSSBOP00000018016; -.
DR Ensembl; ENSSBOT00000034849; ENSSBOP00000018034; ENSSBOG00000025624.
DR GeneID; 101033157; -.
DR CTD; 3975; -.
DR GeneTree; ENSGT00940000160834; -.
DR OrthoDB; 1070389at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; ISS:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; ISS:UniProtKB.
DR GO; GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; ISS:UniProtKB.
DR GO; GO:0021937; P:cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; ISS:UniProtKB.
DR GO; GO:0021549; P:cerebellum development; ISS:UniProtKB.
DR GO; GO:0060067; P:cervix development; ISS:UniProtKB.
DR GO; GO:0072049; P:comma-shaped body morphogenesis; ISS:UniProtKB.
DR GO; GO:0097379; P:dorsal spinal cord interneuron posterior axon guidance; ISS:UniProtKB.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR GO; GO:0001705; P:ectoderm formation; ISS:UniProtKB.
DR GO; GO:0009880; P:embryonic pattern specification; ISS:UniProtKB.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; ISS:UniProtKB.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; ISS:UniProtKB.
DR GO; GO:0001706; P:endoderm formation; ISS:UniProtKB.
DR GO; GO:0060429; P:epithelium development; ISS:UniProtKB.
DR GO; GO:0021871; P:forebrain regionalization; ISS:UniProtKB.
DR GO; GO:0001702; P:gastrulation with mouth forming second; ISS:UniProtKB.
DR GO; GO:0060322; P:head development; ISS:UniProtKB.
DR GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR GO; GO:0097477; P:lateral motor column neuron migration; ISS:UniProtKB.
DR GO; GO:0008045; P:motor neuron axon guidance; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0072178; P:nephric duct morphogenesis; ISS:UniProtKB.
DR GO; GO:0060066; P:oviduct development; ISS:UniProtKB.
DR GO; GO:0035846; P:oviduct epithelium development; ISS:UniProtKB.
DR GO; GO:0061205; P:paramesonephric duct development; ISS:UniProtKB.
DR GO; GO:0007389; P:pattern specification process; ISS:UniProtKB.
DR GO; GO:2000744; P:positive regulation of anterior head development; ISS:UniProtKB.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0040019; P:positive regulation of embryonic development; ISS:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
DR GO; GO:2000768; P:positive regulation of nephron tubule epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0009791; P:post-embryonic development; ISS:UniProtKB.
DR GO; GO:0090009; P:primitive streak formation; ISS:UniProtKB.
DR GO; GO:0010468; P:regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0072077; P:renal vesicle morphogenesis; ISS:UniProtKB.
DR GO; GO:0010842; P:retina layer formation; ISS:UniProtKB.
DR GO; GO:0072050; P:S-shaped body morphogenesis; ISS:UniProtKB.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; ISS:UniProtKB.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0001657; P:ureteric bud development; ISS:UniProtKB.
DR GO; GO:0001655; P:urogenital system development; ISS:UniProtKB.
DR GO; GO:0035847; P:uterine epithelium development; ISS:UniProtKB.
DR GO; GO:0060065; P:uterus development; ISS:UniProtKB.
DR GO; GO:0060068; P:vagina development; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox; LIM domain;
KW Metal-binding; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..406
FT /note="LIM/homeobox protein Lhx1"
FT /id="PRO_0000075774"
FT DOMAIN 4..54
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 63..117
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 180..239
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 128..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P63007"
SQ SEQUENCE 406 AA; 44794 MW; A7F7ED333998ACEB CRC64;
MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY CKNDFFRCFG
TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST GEELYIIDEN KFVCKEDYLS
NSSVAKENSL HSATTGSDPS LSPDSQDPSQ DDAKDSESAN VSDKEGGSNE NDDQNLGAKR
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ
LSALGARRHA FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP
PSSQAQTPVD LPFVPSSGPS GTPLGGLEHP LPGHHPSSEA QRFTDILAHP PGDSPSPEPS
LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM NEAAVW
