LHX2_RAT
ID LHX2_RAT Reviewed; 426 AA.
AC P36198;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 25-MAY-2022, entry version 139.
DE RecName: Full=LIM/homeobox protein Lhx2;
DE Short=Homeobox protein LH-2;
DE Short=LIM homeobox protein 2;
GN Name=Lhx2; Synonyms=Lh2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=7678338; DOI=10.1073/pnas.90.1.227;
RA Xu Y., Baldassare M., Fisher P., Rathbun G., Oltz E.M., Yancopoulos G.D.,
RA Jessell T.M., Alt F.W.;
RT "LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and
RT neural cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:227-231(1993).
CC -!- FUNCTION: Acts as a transcriptional activator. Stimulates the promoter
CC of the alpha-glycoprotein gene. Transcriptional regulatory protein
CC involved in the control of cell differentiation in developing lymphoid
CC and neural cell types (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via LIM domains) with CITED2. Interacts with
CC POU4F2. {ECO:0000250|UniProtKB:Q9Z0S2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Found in discrete regions of the developing CNS,
CC primarily in diencephalic and telencephalic structures and a subset of
CC lymphoid tissues. Also found in embryonic spinal cord and fetal liver.
CC -!- DEVELOPMENTAL STAGE: Expressed in developing lymphocytes and neural
CC cells. Maximal expression is found in pre-B-lymphocytes.
CC -!- DOMAIN: LIM domains are necessary for transcription activation.
CC {ECO:0000250}.
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DR EMBL; L06804; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; A47179; A47179.
DR AlphaFoldDB; P36198; -.
DR SMR; P36198; -.
DR STRING; 10116.ENSRNOP00000014452; -.
DR PaxDb; P36198; -.
DR UCSC; RGD:71076; rat.
DR RGD; 71076; Lhx2.
DR eggNOG; KOG0490; Eukaryota.
DR InParanoid; P36198; -.
DR PhylomeDB; P36198; -.
DR PRO; PR:P36198; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003682; F:chromatin binding; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; ISO:RGD.
DR GO; GO:0048675; P:axon extension; ISO:RGD.
DR GO; GO:0007411; P:axon guidance; ISO:RGD.
DR GO; GO:0007420; P:brain development; ISO:RGD.
DR GO; GO:0021987; P:cerebral cortex development; ISO:RGD.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; ISO:RGD.
DR GO; GO:0001942; P:hair follicle development; ISO:RGD.
DR GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; ISO:RGD.
DR GO; GO:0007498; P:mesoderm development; ISO:RGD.
DR GO; GO:0045814; P:negative regulation of gene expression, epigenetic; ISO:RGD.
DR GO; GO:0050768; P:negative regulation of neurogenesis; ISO:RGD.
DR GO; GO:2000678; P:negative regulation of transcription regulatory region DNA binding; ISO:RGD.
DR GO; GO:0007399; P:nervous system development; ISO:RGD.
DR GO; GO:0001843; P:neural tube closure; ISO:RGD.
DR GO; GO:0022008; P:neurogenesis; ISO:RGD.
DR GO; GO:0030182; P:neuron differentiation; IEP:RGD.
DR GO; GO:0021772; P:olfactory bulb development; ISO:RGD.
DR GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060041; P:retina development in camera-type eye; ISO:RGD.
DR GO; GO:0021537; P:telencephalon development; ISO:RGD.
DR GO; GO:0021978; P:telencephalon regionalization; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..426
FT /note="LIM/homeobox protein Lhx2"
FT /id="PRO_0000075780"
FT DOMAIN 52..104
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 114..167
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 264..323
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 14..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 305..321
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 328..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 47419 MW; DC8FA3DB4572BB40 CRC64;
MLFHSLSGPE VHGVIDEMDR RQERGSGISS AIDRGDTETT MPSISSDRAA LCAGCGGKIS
DRYYLLAVDK QWHMRCLKCC ECKLNLESEL TCFSKDGSIY CKEDYYRRFS VQRCARCHLG
ISESEMVMRA RDLVYHLNCF TCTTCNKMLT TGDHFGMKDS LVYCRLHFEA LLQGEYPPHF
NHADVARAAA AAEQLRVQDW AQLGLTLGLP YYNGVGTVQK GRPRKRKSPG PGADLAAYNA
ALSCNENDAE HLDRDQPYPS SQKTKRMRTS FKHHQLRTMK SYFAINHNPD AKDLKQLAQK
TGLTKRVLQV WFQNARAKFR RNLLRQENTG VDKTSDATLQ TGTPSGPASE LSNASLSPSS
TPTTLTDLTS PTLPTVTSVL TSVPGNLEAT SPTALHKRLL PTFSNDSPPP SPLSPHDFFK
KEIIFS
