LHX3_CHICK
ID LHX3_CHICK Reviewed; 395 AA.
AC P53412;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=LIM/homeobox protein Lhx3;
DE Short=LIM homeobox protein 3;
DE AltName: Full=Homeobox protein LIM-3;
GN Name=LHX3; Synonyms=LIM-3, LIM3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Spinal cord;
RX PubMed=7528105; DOI=10.1016/0092-8674(94)90027-2;
RA Tsuchida T., Ensini M., Morton S.B., Baldassare M., Edlund T.,
RA Jessell T.M., Pfaff S.L.;
RT "Topographic organization of embryonic motor neurons defined by expression
RT of LIM homeobox genes.";
RL Cell 79:957-970(1994).
CC -!- FUNCTION: Transcriptional factor that defines subclasses of motoneurons
CC that segregate into columns in the spinal cord and select distinct axon
CC pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed prior to the formation of distinct motor
CC axon pathways and before the segregation of motor neurons into columns.
CC Expression restricted to the medial subdivision of the median motor
CC column (MMCm). {ECO:0000269|PubMed:7528105}.
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DR EMBL; L35570; AAA62174.1; -; mRNA.
DR PIR; I50376; I50376.
DR RefSeq; NP_001025506.1; NM_001030335.1.
DR AlphaFoldDB; P53412; -.
DR SMR; P53412; -.
DR STRING; 9031.ENSGALP00000002660; -.
DR PaxDb; P53412; -.
DR PRIDE; P53412; -.
DR Ensembl; ENSGALT00000002663; ENSGALP00000002660; ENSGALG00000003928.
DR GeneID; 373940; -.
DR KEGG; gga:373940; -.
DR CTD; 8022; -.
DR VEuPathDB; HostDB:geneid_373940; -.
DR eggNOG; KOG4577; Eukaryota.
DR GeneTree; ENSGT00940000160316; -.
DR HOGENOM; CLU_027802_5_0_1; -.
DR InParanoid; P53412; -.
DR OMA; CTFRGTR; -.
DR OrthoDB; 1174754at2759; -.
DR PhylomeDB; P53412; -.
DR TreeFam; TF315442; -.
DR PRO; PR:P53412; -.
DR Proteomes; UP000000539; Chromosome 17.
DR ExpressionAtlas; P53412; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR GO; GO:0021526; P:medial motor column neuron differentiation; IEA:Ensembl.
DR GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0060127; P:prolactin secreting cell differentiation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060126; P:somatotropin secreting cell differentiation; IEA:Ensembl.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl.
DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IEA:Ensembl.
DR GO; GO:0060129; P:thyroid-stimulating hormone-secreting cell differentiation; IEA:Ensembl.
DR GO; GO:0021521; P:ventral spinal cord interneuron specification; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..395
FT /note="LIM/homeobox protein Lhx3"
FT /id="PRO_0000075784"
FT DOMAIN 28..78
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 87..141
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 154..213
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 209..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 43805 MW; AC196D78C01CFDBE CRC64;
MLLERVRAGS EKAAELCPFP RSPEIPLCAG CNQHIVDRFI LKVLDRHWHS KCLKCSDCQT
QLAEKCFSRG DGVYCKEDFF KRFGTKCAAC QQGIPPTQVV RRAQDFVYHL HCFACIVCKR
QLATGDEFYL MEDSRLVCKA DYETAKQREA ESTAKRPRTT ITAKQLETLK NAYNNSPKPA
RHVREQLSSE TGLDMRVVQV WFQNRRAKEK RLKKDAGRQR WGQYFRNMKR SRGTSKSDKD
SIQEEGPDSD AEVSFTDEPS MSEMSHSNGI YSNLSEASPA LGRQAGTNGG FSLDHSGIPA
QDQYHDLRSN SPYGIPQSPA SLQALPGHQP LISSLVYPDS GLGIMGQGGQ GVPQSMRVLA
GNGPSSDLST GSSGGYPDFP ASPASWLDEV DHAQF
