ID   LHX3_DANRE              Reviewed;         398 AA.
AC   Q90421;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=LIM/homeobox protein Lhx3;
DE            Short=LIM homeobox protein 3;
DE   AltName: Full=Homeobox protein LIM-3;
GN   Name=lhx3; Synonyms=lim3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8575312; DOI=10.1242/dev.121.12.4117;
RA   Appel B., Korzh V., Glasgow E., Thor S., Edlund T., Dawid I.B., Eisen J.S.;
RT   "Motoneuron fate specification revealed by patterned LIM homeobox gene
RT   expression in embryonic zebrafish.";
RL   Development 121:4117-4125(1995).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; U34590; AAA76714.1; -; mRNA.
DR   RefSeq; NP_571283.1; NM_131208.1.
DR   AlphaFoldDB; Q90421; -.
DR   SMR; Q90421; -.
DR   GeneID; 30455; -.
DR   KEGG; dre:30455; -.
DR   CTD; 8022; -.
DR   ZFIN; ZDB-GENE-980526-131; lhx3.
DR   InParanoid; Q90421; -.
DR   OrthoDB; 1174754at2759; -.
DR   PhylomeDB; Q90421; -.
DR   PRO; PR:Q90421; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021521; P:ventral spinal cord interneuron specification; IGI:ZFIN.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..398
FT                   /note="LIM/homeobox protein Lhx3"
FT                   /id="PRO_0000075785"
FT   DOMAIN          28..78
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          87..141
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        154..213
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          208..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          307..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..246
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   398 AA;  44226 MW;  FD298F0D1A725C1F CRC64;
     MLLEHPGSSC QNAGNYTRYS SSQDIPVCAG CNQHIVDRFI LKVLDRHWHS KCLKCSDCQS
     QLADKCFSRG DSVYCKDDFF KRFGTKCAAC QQGIPPTQVV RRAQDFVYHL HCFACIVCKR
     QLATGDEYYL MEDSRLVCKA DYETAKQREA DSTAKRPRTT ITAKQLETLK NAYNNSPKPA
     RHVREQLSTE TGLDMRVVQV WFQNRRAKEK RLKKDAGRQR WGQYFRNMKR SRGTSKSDKD
     STQEDGMDSD AEVSFTDEPP MSDLGHSNGI YSSLSESSPA LSRQGGNHPA FPLEHGAIIP
     SQEPYHDIQA SSPYSLPQSP GPLQPLPRHQ PLISSLVYPE SGLPMAGQSG GQDMTPGVRM
     MAAGNGPSSD LSTGSSGGYP DFPASPASWL DEVDHAQF