ID   LHX5_DANRE              Reviewed;         399 AA.
AC   P52889; Q4KMK6;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=LIM/homeobox protein Lhx5;
DE            Short=LIM homeobox protein 5;
DE   AltName: Full=Homeobox protein LIM-5;
GN   Name=lhx5; Synonyms=lim5;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7649385; DOI=10.1006/dbio.1995.1238;
RA   Toyama R., Curtiss P.E., Otani H., Kimura M., Dawid I.B., Taira M.;
RT   "The LIM class homeobox gene lim5: implied role in CNS patterning in
RT   Xenopus and zebrafish.";
RL   Dev. Biol. 170:583-593(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in the patterning of the nervous system, in
CC       particular in the early specification of the diencephalon.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; L42547; AAA99465.1; -; mRNA.
DR   EMBL; BC098523; AAH98523.1; -; mRNA.
DR   RefSeq; NP_571293.1; NM_131218.1.
DR   AlphaFoldDB; P52889; -.
DR   SMR; P52889; -.
DR   BioGRID; 78646; 3.
DR   STRING; 7955.ENSDARP00000075139; -.
DR   PaxDb; P52889; -.
DR   PRIDE; P52889; -.
DR   Ensembl; ENSDART00000080693; ENSDARP00000075139; ENSDARG00000057936.
DR   GeneID; 30465; -.
DR   KEGG; dre:30465; -.
DR   CTD; 64211; -.
DR   ZFIN; ZDB-GENE-980526-484; lhx5.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000166328; -.
DR   HOGENOM; CLU_027802_3_1_1; -.
DR   InParanoid; P52889; -.
DR   OMA; CSCNLTE; -.
DR   OrthoDB; 1070389at2759; -.
DR   PhylomeDB; P52889; -.
DR   TreeFam; TF315442; -.
DR   PRO; PR:P52889; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000057936; Expressed in ventral thalamus and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001654; P:eye development; IGI:ZFIN.
DR   GO; GO:0030900; P:forebrain development; IDA:ZFIN.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..399
FT                   /note="LIM/homeobox protein Lhx5"
FT                   /id="PRO_0000075792"
FT   DOMAIN          3..61
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          62..125
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        180..239
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          136..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..179
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..387
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   399 AA;  44513 MW;  C0D7BB1B86D032DA CRC64;
     MMVHCAGCER PILDRFLLNV LDRAWHAKCV QCCECNCNLT EKCFSRDGKL YCKIDFFRRF
     GTKCAGCLQG ISPSDLVRRA RSKVFHLNCF TCMVCNKQLS TGEELYVIDE NKFVCKEDYL
     SASAIKEVNL NSVSSCTDRS LSPDLPDQIQ DDTKETDNST SSDKDTNNNE NEEQNSCTKR
     RGPRTTIKAK QLETLKAAFV ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ
     LSALGARRHA FFRGPRRMRP LGGRLEDPDI MGPGGYSYYG EYQGDYYGPV VNYDFFPHGP
     PSSQAHSPAE SPYLLSSGSG ALEGGPVSAH HPSDDQRFTD MISHADTPSP EPGMTGPLHS
     NPQGEGGFTG SPPFPLANNT SYSGPMSHPG QEMGENTVW