LHX5_HUMAN
ID LHX5_HUMAN Reviewed; 402 AA.
AC Q9H2C1; Q32MA4;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=LIM/homeobox protein Lhx5;
DE Short=LIM homeobox protein 5;
GN Name=LHX5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11137295; DOI=10.1016/s0378-1119(00)00466-2;
RA Zhao Y., Hermesz E., Yarolin M.C., Westphal H.;
RT "Genomic structure, chromosomal localization and expression of the human
RT LIM-homeobox gene LHX5.";
RL Gene 260:95-101(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays an essential role in the regulation of neuronal
CC differentiation and migration during development of the central nervous
CC system.
CC -!- INTERACTION:
CC Q9H2C1; P55212: CASP6; NbExp=3; IntAct=EBI-25835523, EBI-718729;
CC Q9H2C1; P06307: CCK; NbExp=3; IntAct=EBI-25835523, EBI-6624398;
CC Q9H2C1; Q8NI60: COQ8A; NbExp=3; IntAct=EBI-25835523, EBI-745535;
CC Q9H2C1; G5E9A7: DMWD; NbExp=3; IntAct=EBI-25835523, EBI-10976677;
CC Q9H2C1; P22607: FGFR3; NbExp=3; IntAct=EBI-25835523, EBI-348399;
CC Q9H2C1; Q14957: GRIN2C; NbExp=3; IntAct=EBI-25835523, EBI-8285963;
CC Q9H2C1; P06396: GSN; NbExp=3; IntAct=EBI-25835523, EBI-351506;
CC Q9H2C1; O00291: HIP1; NbExp=3; IntAct=EBI-25835523, EBI-473886;
CC Q9H2C1; Q5SUL5: HLA-A; NbExp=3; IntAct=EBI-25835523, EBI-8561769;
CC Q9H2C1; P42858: HTT; NbExp=15; IntAct=EBI-25835523, EBI-466029;
CC Q9H2C1; Q92993: KAT5; NbExp=3; IntAct=EBI-25835523, EBI-399080;
CC Q9H2C1; P13473-2: LAMP2; NbExp=3; IntAct=EBI-25835523, EBI-21591415;
CC Q9H2C1; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-25835523, EBI-11742507;
CC Q9H2C1; Q7Z412: PEX26; NbExp=3; IntAct=EBI-25835523, EBI-752057;
CC Q9H2C1; D3DTS7: PMP22; NbExp=3; IntAct=EBI-25835523, EBI-25882629;
CC Q9H2C1; P23284: PPIB; NbExp=3; IntAct=EBI-25835523, EBI-359252;
CC Q9H2C1; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-25835523, EBI-5280197;
CC Q9H2C1; P62826: RAN; NbExp=3; IntAct=EBI-25835523, EBI-286642;
CC Q9H2C1; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-25835523, EBI-9090795;
CC Q9H2C1; P37840: SNCA; NbExp=3; IntAct=EBI-25835523, EBI-985879;
CC Q9H2C1; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-25835523, EBI-5235340;
CC Q9H2C1; Q86WV8: TSC1; NbExp=3; IntAct=EBI-25835523, EBI-12806590;
CC Q9H2C1; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-25835523, EBI-741480;
CC Q9H2C1; P22695: UQCRC2; NbExp=3; IntAct=EBI-25835523, EBI-1051424;
CC Q9H2C1; P61981: YWHAG; NbExp=3; IntAct=EBI-25835523, EBI-359832;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in fetal brain and in various regions of
CC the adult central nervous system including the spinal cord, the
CC thalamus, and the cerebellum.
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DR EMBL; AF291181; AAG36963.1; -; mRNA.
DR EMBL; BC109230; AAI09231.1; -; mRNA.
DR CCDS; CCDS9171.1; -.
DR RefSeq; NP_071758.1; NM_022363.2.
DR AlphaFoldDB; Q9H2C1; -.
DR SMR; Q9H2C1; -.
DR IntAct; Q9H2C1; 25.
DR STRING; 9606.ENSP00000261731; -.
DR iPTMnet; Q9H2C1; -.
DR PhosphoSitePlus; Q9H2C1; -.
DR BioMuta; LHX5; -.
DR DMDM; 18202938; -.
DR EPD; Q9H2C1; -.
DR MassIVE; Q9H2C1; -.
DR PaxDb; Q9H2C1; -.
DR PeptideAtlas; Q9H2C1; -.
DR PRIDE; Q9H2C1; -.
DR ProteomicsDB; 80526; -.
DR Antibodypedia; 31279; 217 antibodies from 30 providers.
DR DNASU; 64211; -.
DR Ensembl; ENST00000261731.4; ENSP00000261731.2; ENSG00000089116.4.
DR GeneID; 64211; -.
DR KEGG; hsa:64211; -.
DR MANE-Select; ENST00000261731.4; ENSP00000261731.2; NM_022363.3; NP_071758.1.
DR UCSC; uc001tvj.2; human.
DR CTD; 64211; -.
DR DisGeNET; 64211; -.
DR GeneCards; LHX5; -.
DR HGNC; HGNC:14216; LHX5.
DR HPA; ENSG00000089116; Group enriched (brain, stomach).
DR MIM; 605992; gene.
DR neXtProt; NX_Q9H2C1; -.
DR OpenTargets; ENSG00000089116; -.
DR PharmGKB; PA30367; -.
DR VEuPathDB; HostDB:ENSG00000089116; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000161536; -.
DR HOGENOM; CLU_027802_3_1_1; -.
DR InParanoid; Q9H2C1; -.
DR OMA; CSCNLTE; -.
DR OrthoDB; 1070389at2759; -.
DR PhylomeDB; Q9H2C1; -.
DR TreeFam; TF315442; -.
DR PathwayCommons; Q9H2C1; -.
DR SignaLink; Q9H2C1; -.
DR BioGRID-ORCS; 64211; 21 hits in 1093 CRISPR screens.
DR GenomeRNAi; 64211; -.
DR Pharos; Q9H2C1; Tbio.
DR PRO; PR:Q9H2C1; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9H2C1; protein.
DR Bgee; ENSG00000089116; Expressed in hypothalamus and 17 other tissues.
DR Genevisible; Q9H2C1; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0021846; P:cell proliferation in forebrain; IEA:Ensembl.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Ensembl.
DR GO; GO:0021937; P:cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; IEA:Ensembl.
DR GO; GO:0021879; P:forebrain neuron differentiation; IEA:Ensembl.
DR GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..402
FT /note="LIM/homeobox protein Lhx5"
FT /id="PRO_0000075789"
FT DOMAIN 3..61
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 62..125
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 180..239
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 124..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 402 AA; 44406 MW; E880138A1A3FCA2A CRC64;
MMVHCAGCER PILDRFLLNV LDRAWHIKCV QCCECKTNLS EKCFSREGKL YCKNDFFRRF
GTKCAGCAQG ISPSDLVRKA RSKVFHLNCF TCMVCNKQLS TGEELYVIDE NKFVCKDDYL
SSSSLKEGSL NSVSSCTDRS LSPDLQDALQ DDPKETDNST SSDKETANNE NEEQNSGTKR
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ
LSALGARRHA FFRSPRRMRP LGGRLDESEM LGSTPYTYYG DYQGDYYAPG SNYDFFAHGP
PSQAQSPADS SFLAASGPGS TPLGALEPPL AGPHAADNPR FTDMISHPDT PSPEPGLPGT
LHPMPGEVFS GGPSPPFPMS GTSGYSGPLS HPNPELNEAA VW
