LHX5_MOUSE
ID LHX5_MOUSE Reviewed; 402 AA.
AC P61375; P50459;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=LIM/homeobox protein Lhx5;
DE Short=LIM homeobox protein 5;
GN Name=Lhx5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=FVB/N;
RX PubMed=8812449; DOI=10.1006/geno.1996.0458;
RA Bertuzzi S., Sheng H.Z., Copeland N.G., Gilbert D.J., Jenkins N.A.,
RA Taira M., Dawid I.B., Westphal H.;
RT "Molecular cloning, structure, and chromosomal localization of the mouse
RT LIM/homeobox gene Lhx5.";
RL Genomics 36:234-239(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays an essential role in the regulation of neuronal
CC differentiation and migration during development of the central nervous
CC system.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; U61155; AAC52842.1; -; mRNA.
DR EMBL; BC057585; AAH57585.1; -; mRNA.
DR CCDS; CCDS19617.1; -.
DR RefSeq; NP_032525.1; NM_008499.5.
DR AlphaFoldDB; P61375; -.
DR SMR; P61375; -.
DR BioGRID; 201158; 10.
DR IntAct; P61375; 2.
DR STRING; 10090.ENSMUSP00000031591; -.
DR iPTMnet; P61375; -.
DR PhosphoSitePlus; P61375; -.
DR PaxDb; P61375; -.
DR PRIDE; P61375; -.
DR ProteomicsDB; 264982; -.
DR Antibodypedia; 31279; 217 antibodies from 30 providers.
DR DNASU; 16873; -.
DR Ensembl; ENSMUST00000031591; ENSMUSP00000031591; ENSMUSG00000029595.
DR GeneID; 16873; -.
DR KEGG; mmu:16873; -.
DR UCSC; uc012ecn.1; mouse.
DR CTD; 64211; -.
DR MGI; MGI:107792; Lhx5.
DR VEuPathDB; HostDB:ENSMUSG00000029595; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000161536; -.
DR HOGENOM; CLU_027802_3_1_1; -.
DR InParanoid; P61375; -.
DR OMA; CSCNLTE; -.
DR OrthoDB; 1070389at2759; -.
DR PhylomeDB; P61375; -.
DR TreeFam; TF315442; -.
DR BioGRID-ORCS; 16873; 3 hits in 77 CRISPR screens.
DR PRO; PR:P61375; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P61375; protein.
DR Bgee; ENSMUSG00000029595; Expressed in white matter of cerebellum and 73 other tissues.
DR ExpressionAtlas; P61375; baseline and differential.
DR Genevisible; P61375; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0021846; P:cell proliferation in forebrain; IMP:MGI.
DR GO; GO:0007267; P:cell-cell signaling; IGI:MGI.
DR GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IGI:MGI.
DR GO; GO:0021937; P:cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; IGI:MGI.
DR GO; GO:0021549; P:cerebellum development; IGI:MGI.
DR GO; GO:0021879; P:forebrain neuron differentiation; IMP:MGI.
DR GO; GO:0021766; P:hippocampus development; IMP:MGI.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IGI:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; IGI:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..402
FT /note="LIM/homeobox protein Lhx5"
FT /id="PRO_0000075790"
FT DOMAIN 3..61
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 62..125
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 180..239
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 124..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 402 AA; 44388 MW; 8F2DBBF1C6237227 CRC64;
MMVHCAGCER PILDRFLLNV LDRAWHIKCV QCCECKTNLS EKCFSREGKL YCKNDFFRRF
GTKCAGCAQG ISPSDLVRKA RSKVFHLNCF TCMVCNKQLS TGEELYVIDE NKFVCKDDYL
SSSSLKEGSL NSVSSCTDRS LSPDLQDPLQ DDPKETDNST SSDKETANNE NEEQNSGTKR
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ
LSALGARRHA FFRSPRRMRP LGGRLDESEM LGSTPYTYYG DYQSDYYAPG GNYDFFAHGP
PSQAQSPADS SFLAASGPGS TPLGALEPPL AGPHGADNPR FTDMISHPDT PSPEPGLPGA
LHPMPGEVFS GGPSPPFPMS GTSGYSGPLS HPNPELNEAA VW
