LHX5_XENLA
ID LHX5_XENLA Reviewed; 402 AA.
AC P37137; Q5U5E0;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=LIM/homeobox protein Lhx5;
DE Short=LIM homeobox protein 5;
DE AltName: Full=Homeobox protein LIM-5;
DE Short=xLIM-5;
DE AltName: Full=xLIM-2A;
GN Name=lhx5; Synonyms=lim2a, lim5;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Gastrula;
RX PubMed=7649385; DOI=10.1006/dbio.1995.1238;
RA Toyama R., Curtiss P.E., Otani H., Kimura M., Dawid I.B., Taira M.;
RT "The LIM class homeobox gene lim5: implied role in CNS patterning in
RT Xenopus and zebrafish.";
RL Dev. Biol. 170:583-593(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INTERACTION WITH LDB1 AND RNF12.
RX PubMed=12874135; DOI=10.1242/dev.00621;
RA Hiratani I., Yamamoto N., Mochizuki T., Ohmori S.-Y., Taira M.;
RT "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1
RT expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer
RT functions.";
RL Development 130:4161-4175(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 188-225.
RX PubMed=1347750; DOI=10.1101/gad.6.3.356;
RA Taira M., Jamrich M., Good P.J., Dawid I.B.;
RT "The LIM domain-containing homeo box gene Xlim-1 is expressed specifically
RT in the organizer region of Xenopus gastrula embryos.";
RL Genes Dev. 6:356-366(1992).
CC -!- FUNCTION: Probably involved in the patterning of the nervous system, in
CC particular in the early specification of the diencephalon.
CC -!- SUBUNIT: Interacts with ldb1 and with the N-terminus of rnf12.
CC {ECO:0000269|PubMed:12874135}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; L42546; AAA99464.1; -; mRNA.
DR EMBL; BC084744; AAH84744.1; -; mRNA.
DR EMBL; Z11587; CAA77672.1; -; mRNA.
DR PIR; S23803; S23803.
DR RefSeq; NP_001084038.1; NM_001090569.1.
DR AlphaFoldDB; P37137; -.
DR SMR; P37137; -.
DR DNASU; 399270; -.
DR GeneID; 399270; -.
DR KEGG; xla:399270; -.
DR CTD; 399270; -.
DR Xenbase; XB-GENE-865965; lhx5.S.
DR OrthoDB; 1070389at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 399270; Expressed in gastrula and 16 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001221; F:transcription coregulator binding; IPI:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..402
FT /note="LIM/homeobox protein Lhx5"
FT /id="PRO_0000075793"
FT DOMAIN 3..61
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 62..125
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 180..239
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 133..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 402 AA; 44959 MW; A5852B94747E09F9 CRC64;
MMAHCAGCER PILDRFLLNV LDRAWHVKCV QCCECKCNLT EKCFSREGKL YCKTDFFRRF
GTKCAGCSLG ISPSDLVRKA RNKVFHLNCF TCMVCNKQLS TGEELYIIDE NKFVCKEDYI
SASSLKESSL NSVSSCTDRS LSPDIQDPIQ DESKETDHST SSDKETANNE NEEQNSGTKR
RGPRTTIKAK QLETLKAAFI ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ
LSALGARRHA FFRSPRRMRP LGGRLDESEI LSSGPYSYYG DYQGDYYGSG NYDFFPHGPP
SSQTQSPADS SYLQNSGPGS TPLGPLESQL SGHHPSENQR YVDMISHPDT PSPEPGMTGP
LHPISGEVFT GGPSPPFSMS NNSGFSGPLP HQNLDINEAT VW
