LHX6_HUMAN
ID LHX6_HUMAN Reviewed; 363 AA.
AC Q9UPM6; A6PVQ1; A6PVQ2; A8K1B2; B7Z4D0; H0YN76; Q5T7S7; Q5T7S8; Q9NTK3;
AC Q9UPM5;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 195.
DE RecName: Full=LIM/homeobox protein Lhx6;
DE Short=LIM homeobox protein 6;
DE AltName: Full=LIM/homeobox protein Lhx6.1;
GN Name=LHX6; Synonyms=LHX6.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=10393337; DOI=10.1093/oxfordjournals.jbchem.a022420;
RA Kimura N., Ueno M., Nakashima K., Taga T.;
RT "A brain region-specific gene product Lhx6.1 interacts with Ldb1 through
RT tandem LIM-domains.";
RL J. Biochem. 126:180-187(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 5 AND 6).
RC TISSUE=Brain, and Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Amygdala;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [6]
RP PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable transcription factor required for the expression of
CC a subset of genes involved in interneurons migration and development.
CC Functions in the specification of cortical interneuron subtypes and in
CC the migration of GABAergic interneuron precursors from the subpallium
CC to the cerebral cortex (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with LDB1 (via the LIM zinc-binding domains).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9UPM6; P01023: A2M; NbExp=3; IntAct=EBI-10258746, EBI-640741;
CC Q9UPM6; P54253: ATXN1; NbExp=6; IntAct=EBI-10258746, EBI-930964;
CC Q9UPM6; P54252: ATXN3; NbExp=3; IntAct=EBI-10258746, EBI-946046;
CC Q9UPM6; Q99829: CPNE1; NbExp=3; IntAct=EBI-10258746, EBI-1642542;
CC Q9UPM6; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-10258746, EBI-6658203;
CC Q9UPM6; Q6QHK4: FIGLA; NbExp=3; IntAct=EBI-10258746, EBI-11976617;
CC Q9UPM6; P28799: GRN; NbExp=3; IntAct=EBI-10258746, EBI-747754;
CC Q9UPM6; P04792: HSPB1; NbExp=3; IntAct=EBI-10258746, EBI-352682;
CC Q9UPM6; P42858: HTT; NbExp=12; IntAct=EBI-10258746, EBI-466029;
CC Q9UPM6; P57682: KLF3; NbExp=3; IntAct=EBI-10258746, EBI-8472267;
CC Q9UPM6; Q86U70: LDB1; NbExp=5; IntAct=EBI-10258746, EBI-677177;
CC Q9UPM6; Q86U70-2: LDB1; NbExp=5; IntAct=EBI-10258746, EBI-11979761;
CC Q9UPM6; Q16656-4: NRF1; NbExp=3; IntAct=EBI-10258746, EBI-11742836;
CC Q9UPM6; O14832: PHYH; NbExp=3; IntAct=EBI-10258746, EBI-721853;
CC Q9UPM6; D3DTS7: PMP22; NbExp=3; IntAct=EBI-10258746, EBI-25882629;
CC Q9UPM6; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10258746, EBI-396669;
CC Q9UPM6; Q01974: ROR2; NbExp=3; IntAct=EBI-10258746, EBI-6422642;
CC Q9UPM6; P37840: SNCA; NbExp=3; IntAct=EBI-10258746, EBI-985879;
CC Q9UPM6; O76024: WFS1; NbExp=3; IntAct=EBI-10258746, EBI-720609;
CC Q9UPM6; P52744: ZNF138; NbExp=3; IntAct=EBI-10258746, EBI-10746567;
CC Q9UPM6; P36508: ZNF76; NbExp=3; IntAct=EBI-10258746, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1; Synonyms=Lhx6.1a;
CC IsoId=Q9UPM6-1; Sequence=Displayed;
CC Name=2; Synonyms=Lhx6.1b;
CC IsoId=Q9UPM6-2; Sequence=VSP_003109;
CC Name=3;
CC IsoId=Q9UPM6-3; Sequence=VSP_037745;
CC Name=4;
CC IsoId=Q9UPM6-4; Sequence=VSP_037745, VSP_003109;
CC Name=5;
CC IsoId=Q9UPM6-5; Sequence=VSP_042073, VSP_003109;
CC Name=6;
CC IsoId=Q9UPM6-6; Sequence=VSP_046043;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI03937.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI03938.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB66505.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB031041; BAA83422.1; -; mRNA.
DR EMBL; AB031042; BAA83423.1; -; mRNA.
DR EMBL; AK126982; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK289827; BAF82516.1; -; mRNA.
DR EMBL; AK297175; BAH12516.1; -; mRNA.
DR EMBL; AK299709; BAH13108.1; -; mRNA.
DR EMBL; AK313808; BAG36544.1; -; mRNA.
DR EMBL; AL162424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW87515.1; -; Genomic_DNA.
DR EMBL; CH471090; EAW87516.1; -; Genomic_DNA.
DR EMBL; AL136570; CAB66505.1; ALT_INIT; mRNA.
DR EMBL; BC103936; AAI03937.1; ALT_INIT; mRNA.
DR EMBL; BC103937; AAI03938.1; ALT_INIT; mRNA.
DR CCDS; CCDS56583.1; -. [Q9UPM6-1]
DR CCDS; CCDS56584.1; -. [Q9UPM6-5]
DR CCDS; CCDS59144.1; -. [Q9UPM6-6]
DR CCDS; CCDS6837.2; -. [Q9UPM6-4]
DR CCDS; CCDS6838.2; -. [Q9UPM6-3]
DR CCDS; CCDS87683.1; -. [Q9UPM6-2]
DR PIR; T46907; T46907.
DR RefSeq; NP_001229262.1; NM_001242333.1. [Q9UPM6-5]
DR RefSeq; NP_001229263.1; NM_001242334.1. [Q9UPM6-1]
DR RefSeq; NP_001229264.1; NM_001242335.1. [Q9UPM6-6]
DR RefSeq; NP_001335119.1; NM_001348190.1. [Q9UPM6-2]
DR RefSeq; NP_055183.2; NM_014368.4. [Q9UPM6-3]
DR RefSeq; NP_954629.2; NM_199160.3. [Q9UPM6-4]
DR AlphaFoldDB; Q9UPM6; -.
DR SMR; Q9UPM6; -.
DR BioGRID; 117692; 57.
DR IntAct; Q9UPM6; 61.
DR STRING; 9606.ENSP00000377854; -.
DR iPTMnet; Q9UPM6; -.
DR PhosphoSitePlus; Q9UPM6; -.
DR BioMuta; LHX6; -.
DR DMDM; 90185239; -.
DR MassIVE; Q9UPM6; -.
DR PaxDb; Q9UPM6; -.
DR PeptideAtlas; Q9UPM6; -.
DR PRIDE; Q9UPM6; -.
DR ProteomicsDB; 85374; -. [Q9UPM6-1]
DR ProteomicsDB; 85375; -. [Q9UPM6-2]
DR ProteomicsDB; 85376; -. [Q9UPM6-3]
DR ProteomicsDB; 85377; -. [Q9UPM6-4]
DR ProteomicsDB; 85378; -. [Q9UPM6-5]
DR Antibodypedia; 16061; 337 antibodies from 34 providers.
DR DNASU; 26468; -.
DR Ensembl; ENST00000340587.7; ENSP00000340137.3; ENSG00000106852.16. [Q9UPM6-4]
DR Ensembl; ENST00000373754.6; ENSP00000362859.2; ENSG00000106852.16. [Q9UPM6-2]
DR Ensembl; ENST00000373755.6; ENSP00000362860.2; ENSG00000106852.16. [Q9UPM6-1]
DR Ensembl; ENST00000394319.9; ENSP00000377854.4; ENSG00000106852.16. [Q9UPM6-3]
DR Ensembl; ENST00000541397.2; ENSP00000441464.2; ENSG00000106852.16. [Q9UPM6-5]
DR Ensembl; ENST00000559895.5; ENSP00000475927.1; ENSG00000106852.16. [Q9UPM6-6]
DR GeneID; 26468; -.
DR KEGG; hsa:26468; -.
DR MANE-Select; ENST00000394319.9; ENSP00000377854.4; NM_014368.5; NP_055183.2. [Q9UPM6-3]
DR UCSC; uc004blx.5; human. [Q9UPM6-1]
DR CTD; 26468; -.
DR DisGeNET; 26468; -.
DR GeneCards; LHX6; -.
DR HGNC; HGNC:21735; LHX6.
DR HPA; ENSG00000106852; Tissue enhanced (adipose).
DR MIM; 608215; gene.
DR neXtProt; NX_Q9UPM6; -.
DR OpenTargets; ENSG00000106852; -.
DR PharmGKB; PA134949308; -.
DR VEuPathDB; HostDB:ENSG00000106852; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000156868; -.
DR HOGENOM; CLU_027802_1_0_1; -.
DR InParanoid; Q9UPM6; -.
DR OMA; QVICTEH; -.
DR OrthoDB; 1161127at2759; -.
DR PhylomeDB; Q9UPM6; -.
DR TreeFam; TF315442; -.
DR PathwayCommons; Q9UPM6; -.
DR SignaLink; Q9UPM6; -.
DR BioGRID-ORCS; 26468; 9 hits in 1097 CRISPR screens.
DR ChiTaRS; LHX6; human.
DR GeneWiki; LHX6; -.
DR GenomeRNAi; 26468; -.
DR Pharos; Q9UPM6; Tbio.
DR PRO; PR:Q9UPM6; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9UPM6; protein.
DR Bgee; ENSG00000106852; Expressed in subcutaneous adipose tissue and 130 other tissues.
DR ExpressionAtlas; Q9UPM6; baseline and differential.
DR Genevisible; Q9UPM6; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0048469; P:cell maturation; ISS:UniProtKB.
DR GO; GO:0021853; P:cerebral cortex GABAergic interneuron migration; ISS:UniProtKB.
DR GO; GO:0021799; P:cerebral cortex radially oriented cell migration; ISS:UniProtKB.
DR GO; GO:0021800; P:cerebral cortex tangential migration; ISS:UniProtKB.
DR GO; GO:0021884; P:forebrain neuron development; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Differentiation; DNA-binding;
KW Homeobox; LIM domain; Metal-binding; Neurogenesis; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..363
FT /note="LIM/homeobox protein Lhx6"
FT /id="PRO_0000075794"
FT DOMAIN 70..122
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 131..184
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DNA_BIND 219..278
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 19..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..194
FT /note="Required for interaction with LDB1"
FT /evidence="ECO:0000250"
FT REGION 203..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..187
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046043"
FT VAR_SEQ 1
FT /note="M -> MYWKHENAAPALPEGCRLPAEGGPATDQVM (in isoform 3
FT and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037745"
FT VAR_SEQ 1
FT /note="M -> MRRGLCRRSAENPDAGPVM (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042073"
FT VAR_SEQ 324..363
FT /note="QVQCGQVHCRLPYTAPPVHLKADMDGPLSNRGEKVILFQY -> HPFSVLTL
FT PALPHLPVGAPQLPLSR (in isoform 2, isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:10393337,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_003109"
FT CONFLICT 16
FT /note="E -> K (in Ref. 1; BAA83422/BAA83423)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9UPM6-2:346
FT /note="L -> F (in Ref. 1; BAA83423)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 363 AA; 40045 MW; 3633B5112D548532 CRC64;
MAQPGSGCKA TTRCLEGTAP PAMAQSDAEA LAGALDKDEG QASPCTPSTP SVCSPPSAAS
SVPSAGKNIC SSCGLEILDR YLLKVNNLIW HVRCLECSVC RTSLRQQNSC YIKNKEIFCK
MDYFSRFGTK CARCGRQIYA SDWVRRARGN AYHLACFACF SCKRQLSTGE EFGLVEEKVL
CRIHYDTMIE NLKRAAENGN GLTLEGAVPS EQDSQPKPAK RARTSFTAEQ LQVMQAQFAQ
DNNPDAQTLQ KLADMTGLSR RVIQVWFQNC RARHKKHTPQ HPVPPSGAPP SRLPSALSDD
IHYTPFSSPE RARMVTLHGY IESQVQCGQV HCRLPYTAPP VHLKADMDGP LSNRGEKVIL
FQY
