ID   LHX9_ASTFA              Reviewed;         377 AA.
AC   A2I8Z7;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=LIM/homeobox protein Lhx9;
DE            Short=LIM homeobox protein 9;
GN   Name=lhx9;
OS   Astyanax fasciatus (Blind cave fish) (Astyanax mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Psalidodon.
OX   NCBI_TaxID=223369;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=17251267; DOI=10.1242/dev.02780;
RA   Menuet A., Alunni A., Joly J.-S., Jeffery W.R., Retaux S.;
RT   "Expanded expression of Sonic Hedgehog in Astyanax cavefish: multiple
RT   consequences on forebrain development and evolution.";
RL   Development 134:845-855(2007).
CC   -!- FUNCTION: May be involved in gonadal development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: In the telencephalon, expressed at 48 hours post-
CC       fertilization (hpf) in the olfactory epithelium.
CC       {ECO:0000269|PubMed:17251267}.
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DR   EMBL; EF175738; ABM55505.1; -; mRNA.
DR   BMRB; A2I8Z7; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   GO; GO:0097380; P:dorsal spinal cord interneuron anterior axon guidance; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00132; LIM; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus; Repeat; Zinc.
FT   CHAIN           1..377
FT                   /note="LIM/homeobox protein Lhx9"
FT                   /id="PRO_0000364230"
FT   DOMAIN          50..111
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          112..174
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DNA_BIND        248..307
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          205..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          358..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   377 AA;  41990 MW;  E5A7DA79C72700E5 CRC64;
     MLFHGIPGEH IQGIMEEMER RSKSESRLAK TVQMNGRETS MPSVSPEKPA LCAGCGSKIS
     DRYYLLAVDK QWHLRCLKCC ECKLALESEL TCFAKDGSIY CKEDYYRRFS VQRCARCHLG
     ISASEMVMRA RDSVYHLSCF TCTSCNKTLT TGDHFGMREN LVYCRAHFES LVQGEYHAPL
     NYAELAAKGG GLALPYFNGA SAVQKGRPRK RKSPAMGIDI NTYNSGCNEN DADHLDRDQQ
     PYPPSQKTKX MRTSFKHHQL RTMKSYFAIN HNPDAKDLKQ LAQKTGLTKR VLQVWFQNAR
     AKFRRNVLRQ ENGGVDKADG TSLPPPSSDS GALTPPSTAT TLTDLTNPSI TVVTSVTSSL
     DSHDSGSPPQ TTLTNLF